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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Clinical use of dendritic cells for cancer therapy显示文摘 | Sébastien Anguille Evelien L Smits Eva Lion Viggo F van Tendeloo Zwi N Berneman | 2014 | Lancet Oncology2014，，7： | 3 |
| 3 | Adjuvant dendritic cell-based tumour vaccination for children with malignant brain tumours显示文摘 | Ardon H De Vleeschouwer S Van Calenbergh F Claes L Kramm CM Rutkowski S Wolff JE Van Gool SW. | 2010 | 中国神经肿瘤杂志2010，8，1： | 3 |
| 4 | Human memory cytotoxic T-lymphocyte(CTL)responses to Hantaan virus infection:identification of virus-specific and cross-reactive CD8(+)CTL epitopes on mucleocapsid protein显示文摘 | Van Epps H L Schmaljohn C S Ennis F A | 1999 | J Virol1999，73，7： | 2 |
| 5 | Accuracy assessment of satellite derived land-cover data: a review显示文摘 | Janssen L F F J M van der Wel | 1994 | Photogrammetric Engineering and Remote Sensing1994，60，4： | 2 |
| 6 | Costimulatory blockade in patients with rheumatoid arthritis: a pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion显示文摘 | MORELAND LW ALTEN R van den BOSCH F l | 2002 | Arthritis Rheum2002，46，6： | 1 |
| 7 | Intestinal uptake Mathot F,van Beijsterveldt L,Preat V,and biodistribution of novel polymeric micelles after oral administration显示文摘 | Mathot F van Beijsterveldt L Preat V | 2006 | J Control Release2006，111，12： | 1 |
| 8 | A new technique for the assay of infectivity of human adenovirus 5 DNA显示文摘 | van der Eb A J | 1973 | Virology1973，52，2： | 1 |
| 9 | Expression of the potato leafroll luteovirus coat protein gene in transgenic potato plant inhibits viral infection显示文摘 | WILLINK D P L HUISMAN M J | 1991 | Plant Molecular Biology1991，17，： | 1 |
| 10 | eal-time PCR assay for the identification of Thrips palmi显示文摘 | KOX L F F van den BELD H E ZIJLSTRA C | 2005 | Bulletin OEPP/EPPO Bulletin2005，35，： | 1 |
| 11 | Vascular permeability factor gene is expressed differentially in normal tissues,macrophages and tumors显示文摘 | Berse B Brown L F van de Water L | 1992 | Mol Biol Cell1992，3，2： | 1 |
| 12 | Nodular fasciitis:correlation of MRI findings and histopathology显示文摘 | WANG X L DE SCHEPPER A M VAN HOENACKER F | 2002 | Skeletal Radiol2002，31，： | 1 |
| 13 | Cross-linked enzyme aggregates : A simple and effective method for the immo- bilization of penicillin acylase显示文摘 | Cao L Van Rantwijk F Sheldon R A | 2000 | Organic Letters2000，2，10： | 1 |
| 14 | Wnt activity defines colon cancer stem ceils and is regulated by the microenvironment 显示文摘 | Vermeulen L De Sousa E Melo F van der Heijden M | 2010 | Nat Cell Biol2010，12，5： | 1 |
| 15 | Identification of pork quality parameters by proteomics 显示文摘 | van de Wiel D F M Zhang W L | 2007 | Meat Science2007，77，1： | 1 |
| 16 | Effect of genetic variants of the heart fatty acid-binding protein gene on intramuscular fat and performan-ce traits in pigs显示文摘 | A J van Erp F L Hardem F J Verburg T H Meuwissen J HVeerkamp and M F te Pas | | 0，，04： | 1 |
| 17 | Design of a stroke dependent damper for the front axle suspension of a truck using multibody system dynamics and numerical optimization显示文摘 | Etman L F P Vernmeulen R C N Van Heck J G A M | | 0，，02： | 1 |
| 18 | Distribution of apoptosis-related proteins in the quail ovary during folliculogengsis:BCL-2,BAX and CPP32显示文摘 | Van Nassauw L Tao L Harrisson F | 1999 | Acta Histochem1999，101，1： | 1 |
| 19 | Simulation of HMA compaction by u-sing FEM 显示文摘 | Ter Huerne H L Van Maarseveen M F A M Molena- ar A A A | 2008 | International Journal of Pavement Engi- neering2008，9，3： | 1 |
| 20 | Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma 显示文摘 | Fregonese L Swan F J van Schadewijk A | 2005 | J Allergy Clin Immunol2005，115，6： | 1 |
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