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1Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery.Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen 2008World Journal of Gastroenterology2008,14,45:4
2Methylenete trahydrofolat reductase gene and coronary artery disease显示文摘 Mamotte CDS Vasikaram SD 1997Circulation1997,95,:1
3Radiographically occult lung cancer treated with fiberoptic bronchoscopic eletrocautery:a pilot study of a simple and inexpensive technique显示文摘Van Boxem TJ Venmans BJ Schramel FM 2005Eur Respir J2005,11,:1
4Using spectral moment data from NOAA's 404-MHz radar wind profilers to observe precipitation显示文摘Ralph FM Neiman P J van de Kamp DW 1995Bullitin of the American Meteorological Society1995,76,10:1
5Gene therapy with apoptin induces regression of xenografted human hepatomas 显示文摘Van der Eb MM Pietersen AM Speetjens FM 2002Cancer Gene Ther2002,9,1:1
6The clinicalvalue of lung imaging fluorescence endoscopy for detectingsynchronous lung cancer显示文摘van Rens MT Schramel FM Elbers JR 2001Lung Cancer2001,32,1:1
7Methylen etetrahydrofo latereductase gene and coronary artery disease 显示文摘 Mamotte CD Vasikaran SD 1997Circulation1997,95,:1
8Epithelial cells acquire invasive properities after the loss of uvomorulin-mediated cell-cell adhesion 显示文摘Behrens J Mareel M Van Roy FM 1989J Cell Biol1989,108,6:1
9Prevalence,extension and characteristic of fluid-fluid levels in bone and soft tissue tumors显示文摘Van Dyck P Vanhoenacker FM Vogel J 0,,12:1
10Thymic stro- real lympbopoietin, a novel proinflammatory mediator in rheuma- toid arthritis that potently activates CDlc + myeloid dendritic cells to attract and stimulate T ceils 显示文摘Moret FM Hack CE van der Wurff-Jacobs KM 2014Arthritis Rheumatol2014,66,5:1
11Feasibility of diffu- sion tensor imaging(DTI) with fibre tractography of the normal fe- male pelvic floor 显示文摘Zijta FM Froeling M van der Paardt MP 2011Eur Radiol2011,21,:1
12Two common,functional polymorphisms in the promoter region of the beta-fibrinogen gene contribute to regulation of plasma fibrinogen concentration显示文摘van't Hooft FM von Bahr SJF Silveira A 0,,:1
13Compa- ring effects of kyphoplasty, vertebmplasty, and non-surgical man- agement in a systematic review of randomized and non-randomized controlled studies显示文摘Papanastassiou ID Phillips FM Van Meirhaeghe J 2012Eur Spine J2012,21,9:1
14National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) symptom evaluation in multinational cohorts of patients with chronicprostatitis/ chronic pelvic pain syndrome 显示文摘Wagenlehner FM van Till JW Magri V 2013Eur Urol2013,63,5:1
15Coexpression of BMI-1 and EZH-2 Polycomb group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma显示文摘van Kemenade FJ Raaphorst FM Blokzijl T 2001Blood2001,97,12:1
16Epithelioid hemangioendothelioma of the lung:clinical and patholngical pitfalls显示文摘Van Kasteren ME Van der Wurff AA Palmen FM 1995Eur Respir1995,8,9:1
17Phase Ⅱ study of docetaxel and carboplatin combination as second-line treatment in metaslatic non-small cell lung cancer显示文摘van Puuen JWG Wachters FM Maas F 2002Proceedings of ASCO2002,21,:1
18Octreotide scintigraphy is a disease activity parameter in Graves' ophthalmopathy显示文摘Gerding MN van-der-Zant FM van Royen EA 1999Clin Endocrinol Oxf1999,50,3:1
19Ghrelin and the hyposomatotropism of obesity 显示文摘Lindeman JH Pijl H Van Dielen FM 2002Obes Res2002,10,11:1
20National institutes of health chronic prostatitis symptom index (NIH-CPSI) symptom evaluation in multinational cohorts of patients with chronic prostatitis/chronic pelvic pain syndrome显示文摘Wagenlehner FM van Till JW Magri V 0,,5:1
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