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| 1 | Challenges in diagnosing mesenteric ischemia显示文摘Early identification of acute mesenteric ischemia (AMI) is challenging. The wide variability in clinical presentation challenges providers to make an early accurate diagnosis. Despite major diagnostic and treatment advances over the past decades, mortality remains high. Arterial embolus and superior mesenteric artery thrombosis are common causes of AMI. Non-occlusive causes are less common, but vasculitis may be important, especially in younger people. Because of the unclear clinical presentation and non-specific laboratory findings, low clinical suspicion may lead to loss of valuable time. During this diagnostic delay, progression of ischemia to transmural bowel infarction with peritonitis and septicemia may further worsen patient outcomes. Several diagnostic modalities are used to assess possible AMI. Multi-detector row computed tomographic angiography is the current gold standard. Although computed tomographic angiography leads to an accurate diagnosis in many cases, early detection is a persistent problem. Because early diagnosis is vital to commence treatment, new diagnostic strategies are needed. A non-invasive simple biochemical test would be ideal to increase clinical suspicion of AMI and would improve patient selection for radiographic evaluation. Thus, AMI could be diagnosed earlier with follow-up computed tomographic angiography or high spatial magnetic resonance imaging. Experimental in vitro and in vivo studies show promise for alpha glutathione S transferase and intestinal fatty acid binding protein as markers for AMI. Future research must confirm the clinical utility of these biochemical markers in the diagnosis of mesenteric ischemia. | Teun C van den Heijkant Bart AC Aerts Joep A Teijink Wim A Buurman Misha DP Luyer | 2013 | World Journal of Gastroenterology2013，19，9： | 31 |
| 2 | Strategies to reduce pulmonary complications after esophagectomy显示文摘Esophagectomy,the surgical removal of all or part of the esophagus,is a surgical procedure that is associated with high morbidity and mortality.Pulmonary complications are an especially important postoperative problem.Therefore,many perioperative strategies to prevent pulmonary complications after esophagectomy have been investigated and introduced in daily clinical practice.Here,we review these strategies,including improvement of patient performance and technical advances such as minimally invasive surgery that have been implemented in recent years.Furthermore,interventions such as methylprednisolone,neutrophil elastase inhibitor and epidural analgesia,which have been shown to reduce pulmonary complications,are discussed.Benefits of the commonly applied routine nasogastric decompression,delay of oral intake and prophylactic mechanical ventilation are unclear,and many of these strategies are also evaluated here.Finally,we will discuss recent insights and new developments aimed to improve pulmonary outcomes after esophagectomy. | Teus J Weijs Jelle P Ruurda Grard AP Nieuwenhuijzen Richard van Hillegersberg Misha DP Luyer | 2013 | World Journal of Gastroenterology2013，19，39： | 17 |
| 3 | Challenges in diagnosing adhesive small bowel obstruction显示文摘Adhesive small bowel obstruction(ASBO)is the most frequently encountered surgical disorder of the small intestine.Up to 80%of ASBO cases resolve spontaneously and do not require invasive treatment.It is important to identify such patients that will benefit from conservative treatment in order to prevent unnecessarily exposing them to the risks associated with surgical intervention,such as morbidity and further adhesion formation.For the remaining ASBO patients,timely surgical intervention is necessary to prevent small bowel strangulation,which may cause intestinal ischemia and bowel necrosis.While early identification of these patients is key to decreasing ASBO-related morbidity and mortality,the non-specific signs and laboratory findings upon clinic presentation limit timely diagnosis and implementation of appropriate clinical management.Combining the clinical presentation findings with those from other diagnostic imaging modalities,such as abdominal X-ray,computed tomography-scan and water-soluble contrast studies,will improve diagnosis of ASBO and help clinicians to better evaluate the potential of conservative management as a safe strategy for a particular patient.Nonetheless,patients who present with moderate findings by all these approaches continue to represent a challenge.A new diagnostic strategy is urgently needed to further improve our ability to identify early signs of strangulated bowel,and this diagnostic modality should be able to indicate when surgical management is required.A number of potential serum markers have been proposed for this purpose,including intestinal fatty acid binding protein andα-glutathione S transferase.On-going research is attempting to clearly define their diagnostic utility and to optimize their potential role in determining which patients should be managed surgically. | Thijs R van Oudheusden Bart AC Aerts Ignace HJT de Hingh Misha DP Luyer | 2013 | World Journal of Gastroenterology2013，19，43： | 7 |
| 4 | Diagnostic value of drain amylase for detecting intrathoracic leakage after esophagectomy显示文摘AIM:To investigate the value of elevated drain amylase concentrations for detecting anastomotic leakage(AL) after minimally invasive Ivor-Lewis esophagectomy(MIILE).METHODS:This was a retrospective analysis of prospectively collected data in two hospitals in the Netherlands. Consecutive patients undergoing MI-ILE were included. A Jackson-Pratt drain next to the dorsal side of the anastomosis and bilateral chest drains were placed at the end of the thoracoscopic procedure. Amylase levels in drain fluid were determined in all patients during at least the first four postoperative days. Contrast computed tomography scans and/or endoscopic imaging were performed in cases of a clinically suspected AL. Anastomotic leakage was defined as any sign of leakage of the esophago-gastric anastomosis on endoscopy,re-operation,radiographic investigations,post mortal examination or when gastro-intestinal contents were found in drain fluid. Receiver operator characteristic curves were used to determine the cut-off values. Sensitivity,specificity,positive predictive value,negative predictive value,risk ratio and overall test accuracy were calculated for elevated drain amylase concentrations.RESULTS:A t o t a l o f 8 9 p a t ie n t s w e re in c lu d e d between March 2013 and August 2014. No differences in group characteristics were observed between patients with and without AL,except for age. Patients with AL were older than were patients without AL(P = 0.01). One patient(1.1%) without AL died within 30 d after surgery due to pneumonia and acute respiratory distress syndrome. Anastomotic leakage that required any intervention occurred in 15 patients(16.9%). Patients with proven anastomotic leakage had higher drain amylase levels than patients without anastomotic leakage [median 384 IU/L(IQR 34-6263) vs median 37 IU/L(IQR 26-66),P = 0.003]. Optimal cut-off values on postoperative days 1,2,and 3 were 350 IU/L,200 IU/L and 160 IU/L,respectively. An elevated amylase level was found in 9 of the 15 patients with AL. Five of these 9 patients had early elevations of their amylase levels,with a median of 2 d(IQR 2-5) before signs and symptoms occurred.CONCLUSION:Measurement of drain amylase levels is an inexpensive and easy tool that may be used to screen for anastomotic leakage soon after MI-ILE. However,clinical validation of this marker is necessary. | Gijs HK Berkelmans Ewout A Kouwenhoven Boudewijn JJ Smeets Teus J Weijs Luis C Silva Corten Marc J van Det Grard AP Nieuwenhuijzen Misha DP Luyer | 2015 | World Journal of Gastroenterology2015，21，30： | 3 |
| 5 | Learning curves in minimally invasive esophagectomy显示文摘Surgical innovation and pioneering are important for improving patient outcome, but can be associated with learning curves. Although learning curves in surgery are a recognized problem, the impact of surgical learning curves is increasing, due to increasing complexity of innovative surgical procedures, the rapid rate at which new interventions are implemented and a decrease in relative effectiveness of new interventions compared to old interventions. For minimally invasive esophagectomy(MIE), there is now robust evidence that implementation can lead to significant learning associated morbidity(morbidity during a learning curve, that could have been avoided if patients were operated by surgeons that have completed the learning curve). This article provides an overview of the evidence of the impact of learning curves after implementation of MIE. In addition, caveats for implementation and available evidence regarding factors that are important for safe implementation and safe pioneering of MIE are discussed. | Frans van Workum Laura Fransen Misha DP Luyer Camiel Rosman | 2018 | World Journal of Gastroenterology2018，24，44： | 2 |
| 6 | Mirtazapine: Efficacy and Tolerability in Comparison With Fluoxetine in Patients With Moderate to Severe Major Depressive Disorder 显示文摘 | Wheatley DP van Moffaert M Timmerman L etal | 1998 | J Clin psychiatry1998，59，16： | 2 |
| 7 | Interference with the ex-pression of a novel human polycomb protein,hPc2,results in cellulartransformation and apoptosis 显示文摘 | Satijn DP Olson DJ van der Vlag J | 1997 | Mol Cell Biol1997，17，10： | 1 |
| 8 | Exploratory MCDA for Handling DeepUncertaintiesiThe Case of Intelligent Speed Adaptation Im-plementation显示文摘 | Van DP JW GM | 2010 | Journal of Multi-criteria Decision Analy-sis2010，，17： | 1 |
| 9 | Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform 显示文摘 | Cormode DP Skajaa T van Schooneveld MM | 2008 | Nano Lett2008，8，11： | 1 |
| 10 | The scintillation intensity and decay from Nd3+4f25d and 4f3excited states in several fluoride crystals显示文摘 | Visser R DP Van Eijk C W E | 1993 | Journal of Physics:Condensed Matter1993，5，44： | 1 |
| 11 | Transpedicular wedge resection osteotomy for the treatment of a kyphotic Andersson lesion complicating ankylosing spondylitis 显示文摘 | Van Royen BJ Kastelijns RC Noske DP etal | 2006 | Eur Spine J2006，15，2： | 1 |
| 12 | High-density lipoprotein loses its anti-inflammatory properties during acute influenza a infection 显示文摘 | Van Lenten BJ Wagner AC Nayak DP | 2001 | Circulation2001，103，18： | 1 |
| 13 | Relationship of steady state and ambulatory blood pressure variability to left ventricular mass and urinary albumin excretion in essential hypertension显示文摘 | Veerman DP De Blok K Van Montfrans A | 1996 | Am J Hypertens1996，9，5： | 1 |
| 14 | Radiotherapy for T1- 2N0 glottic cancer:a multivariate analysis of predictive factors for the long-term outcome in 1050 patients and a prospective assessment of quality of life and voice handicap index in a subset of 233 patients显示文摘 | A1-Mamgani A van Rooij PH Woutersen DP | 2013 | Clin Oto- laryngol2013，38，4： | 1 |
| 15 | Frequency of falsenegative reactions to the fragranc e mix显示文摘 | De Groot AC Van der Kley AMJ Bruynzeel DP | 1993 | Contact Dermatitis1993，28，： | 1 |
| 16 | Ketamine inhibits LPS-induced tumour necrosis factor-alpha and interleukin-6 in an equine macrophage cell line显示文摘 | Lankveld DP Bull S Van DP | 2005 | Vet Res2005，36，22： | 1 |
| 17 | Serumlevels of C一reactive protein and procalcitonin in critically illpatients with cirrhosis of the liver 显示文摘 | BOTA DP van NUFFELEN M ZAKARIAH AN | 2005 | J Lab Clin Med2005，146，6： | 1 |
| 18 | (99m)Tchexamethyl propylene-aminoxime single-photon emissioncomputed tomography prediction of conversion from mildcognitive impairment to Alzheimer disease 显示文摘 | Devanand DP Van Heertum RL Kegeles LS | 2010 | Am J GeriatrPsychiatry2010，18，11： | 1 |
| 19 | Role of Toll-]ike receptor 4 in the initiation and progression of atherosclerotic disease 显示文摘 | Pasterkamp G Van Keulen JK De Kleijn DP | 2004 | Eur J Clin Invest2004，34，5： | 1 |
| 20 | (99m) Tchexa- methyl-propylene-aminoxime single-photon emission computed tomography prediction of conversion from mild cognitive impairment to Alzheimer disease 显示文摘 | Devanand DP Van Heertum RL Kegeles LS | 2010 | Am J Geriatr Psychiatry2010，18，： | 1 |
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