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| 1 | Magnetic resonance imaging may predict deep remission in patients with perianal fistulizing Crohn's disease显示文摘AIM To evaluate the imaging course of Crohn's disease(CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor(TNF)-α therapy and identify predictors of deep remission.METHODS All patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging(MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. Clinical assessment(remission, response and non-response) was based on Present's criteria. Rectoscopic patterns, MRI Van Assche score, and MRI fistula activity signs(T2 signal and contrast enhancement) were collected for the two MR examinations. Fistula healing was defined as the absence of T2 hyperintensity and contrast enhancement on MRI. Deep remission was defined as the association of both clinical remission, absence of anal canal ulcers and healing on MRI. Characteristics and imaging patterns of patients with and without deep remission were compared by univariate and multivariate analyses.RESULTS Forty-nine consecutive patients(31 females and 18 males) were included. They ranged in age from 14-70 years(mean, 33 years). MRI and clinical assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. Clinical remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respectively. Deep remission was observed in 32.7% of patients. Among the 26 patients in clinical remission, 10 had persisting inflammation of fistulas on MRI(T2 hyperintensity, n = 7; contrast enhancement, n = 10). Univariate analysis showed that deep remission was associated with the absence of rectal involvement and the absence of switch of anti-TNF-α treatment or surgery requirement. Multivariate analysis demonstrated that only the absence of rectal involvement(OR = 4.6; 95%CI: 1.03-20.5) was associated with deep remission.CONCLUSION Deep remission is achieved in approximately one third of patients on maintenance anti-TNF-α therapy. Absence of rectal involvement is predictive of deep remission. | Lucie Thomassin Laura Armengol-Debeir Cloé Charpentier Valerie Bridoux Edith Koning Guillaume Savoye Céline Savoye-Collet | 2017 | World Journal of Gastroenterology2017，23，23： | 5 |
| 2 | Current application of proteomics in biomarker discoveryfor inflammatory bowel disease显示文摘Recently, the field of proteomics has rapidly expanded in its application towards clinical research with objectives ranging from elucidating disease pathogenesis to discovering clinical biomarkers. As proteins govern and/or reflect underlying cellular processes, the study of proteomics provides an attractive avenue for research as it allows for the rapid identification of protein profiles in a biological sample. Inflammatory bowel disease(IBD) encompasses several heterogeneous and chronic conditions of the gastrointestinal tract. Proteomic technology provides a powerful means of addressing major challenges in IBD today, especially for identifying biomarkers to improve its diagnosis and management. This review will examine the current state of IBD proteomics research and its use in biomarker research. Furthermore, we also discuss the challenges of translating proteomic research into clinically relevant tools. The potential application of this growing field is enormous and is likely to provide significant insights towards improving our future understanding and management of IBD. | Patrick PY Chan Valerie C Wasinger Rupert W Leong | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 5 |
| 3 | Processing of low-density silica gel by critical point drying or ambient pressure drying显示文摘 | Valerie D Land Thomas M Harris Dale C Teeters | 2001 | Journal of Non-Crystalline Solids2001，，1： | 2 |
| 4 | MicroRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer 显示文摘 | Braconi C Kogure T Valeri N | 2011 | Oncogene2011，30，47： | 1 |
| 5 | Drug targets for traumatic brain injury from poly(ADP-ribose)poly-merase pathway modulation 显示文摘 | Valerie C Besson | 2009 | Br J Pharmacol2009，157，5： | 1 |
| 6 | MieroRNA-135b promotes cancer progression by acting as a downstream effector of oneogenic pathways in colon cancer显示文摘 | Valeri N Braeoni C Gasparini P | 2014 | Cancer Cell2014，25，4： | 1 |
| 7 | microRNA-29 canregulate expression of the long non-coding RNA gene MEG3 inhepatocellular cancer显示文摘 | Braconi C Kogure T Valeri N | 2011 | Oncogene2011，30，47： | 1 |
| 8 | A multicenterstudy of in vitro and in vivo values in human RBCsfrozen with 40-percent(wt/vol)glycerol and storedafter deglycerolization for 15 days at 4 degrees C inAS-3:assessment of RBC processing in the ACP 215显示文摘 | Valeri C R Ragno G Pivacek LE | 2001 | Transfusion2001，41，7： | 1 |
| 9 | Significance of immunocytochemical expression of E-cadherin,N-cadherin and CD44 in serous effusions using liquid-based cytology显示文摘 | Malle D Valeri RM Photiou C | 2005 | Acta Cytol2005，49，： | 1 |
| 10 | A pulse system for spectrum analysis of magnetoelastic biosensors显示文摘 | SHEN W LESLIE C M VALERY A P | 2010 | Applied Physics Letters2010，96，16： | 1 |
| 11 | Preschooler's physical activity levels and associations with lesson context,teacher's behavior,and environment during preschool physical education显示文摘 | Van Cauwenberghe E Valery L Jessica G Ilse D B Greet C | 2012 | Early Childhood Research Quarterly2012，27，2： | 1 |
| 12 | microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer显示文摘 | Braconi C Kogure T Valeri N | 2011 | Oncogene2011，30，47： | 1 |
| 13 | MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer显示文摘 | Valeri N Braconi C Gasparini P | 2014 | Cancer Cell2014，25，4： | 1 |
| 14 | Food intake and nutritional status in stable hemodialysis patients显示文摘 | Cupisti A D'Alessandro C Valeri A | 2010 | Ren Fail2010，32，： | 1 |
| 15 | Cassini star tracking and identification architecture显示文摘 | Valerie C Thomas James W Alexander | 2000 | Proceedings of SPIE2000，2221，： | 1 |
| 16 | microRNA-29 can regulateexpression of the long non-coding RNA gene MEG3 inhepatocellular cancer显示文摘 | Braconi C Kogure T Valeri N | 2011 | Oncogene2011，30，47： | 1 |
| 17 | Crosslinking studies in gelatin capsules treated with formaldehyde and in capsules exposed to elevated temperature and humidity显示文摘 | Clyde M Ofner Ⅲ Yu-E Zhang Valerie C Jobeck Bill J Bowman | | J Parm Sci0，90，1： | 1 |
| 18 | Effects of temperature on bleeding time and clotting time in normal male and female volunteers显示文摘 | VALERI C R MACGREGOR H CASSIDY G | 1995 | Crit Care Med1995，23，4： | 1 |
| 19 | Internet Us- age by Low- literacy Adults Seeking Health Information: an observational analysis 显示文摘 | Mehret S B Valerie M M Lonelyss C | 2004 | Journal of Medical Internet Re- search2004，6，3： | 1 |
| 20 | In vi- vo Survival of aphere Z sed red ceils, frozen with 40 percent W/V glycerol, deglycerol 2 ized with the Haemonetics Model 215 and stored at 4℃ in As 23 for up to 21 days显示文摘 | VALERI C R RAGNO G PIVACEK L | 2001 | Transfusion2001，41，： | 1 |
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