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| 1 | Chloroplast phylogenomic data support Eocene amphi-Pacific early radiation for the Asian Palmate core Araliaceae显示文摘Traditional phylogenies based on analysis of multiple genes have failed to obtain a well-resolved evolutionary history for the backbone of the Asian Palmate group of Araliaceae,the largest clade of the family.In this study,we applied the genome skimming approach of next-generation sequencing to address whether the lack of resolution at the base of the Asian Palmate tree is due to molecular sampling error or the footprint of ancient radiation.Twenty-nine complete plastid genomes of Araliaceae(17 newly sequenced)were analyzed(RAxML,Beast,Lagrange,and BioGeoBears)to provide the first phylogenomic reconstruction of the group(95%of genera included).As a result,the early divergences of the Asian Palmate group have been clarified but the backbone of its core is not totally resolved,with short internal branches pointing to an ancient radiation scenario.East Asia is inferred as the most likely ancestral area for the Asian Palmate group(from late Paleocene to Eocene)from which early colonization of the Neotropics is inferred during the Eocene.The radiation of the core Palmate group took place during the late Eocene,most likely in the context of the Boreotropical hypothesis.Recurrent episodes of southward migration(to the tropics)coupled with northern latitude local extinctions(promoting geographic isolation of lineages)followed by northward expansion(promoting contact of lineages that erased the trace of preceding geographic isolation)are hypothesized to have linked to the alternation of the cold and warm periods of the Eocene. | Virginia Valcarcel Jun Wen | 2019 | Journal of Systematics and Evolution2019，57，6： | 10 |
| 2 | 新型分子靶向药物联合放疗在肺癌中的应用显示文摘非小细胞肺癌(non-small cell lung cancer,NSCLC)约占肺癌总病例数的80%-85%,对于Ⅲ期患者来说,NSCLC约占肺癌总病例数的40%。不可切除Ⅲ期NSCLC的治疗为以铂类为基础的化疗联合胸部放疗。本文将综述正在研发中且有可能用于联合治疗的新型靶向制剂。其中最具前景的策略之一为表皮生长因子受体(epidermal growth factor receptor,EGFR)通路的抑制。放疗可激活EGFR信号,通过诱导细胞增殖并增强DNA修复而导致放疗抵抗。几项临床前模型研究表明西妥昔单抗与放疗联合具有协同效应。几项Ⅱ期试验评估了西妥昔单抗与放疗同步使用的安全性与疗效,结果喜人。吉非替尼对多种细胞系具有放疗增敏作用,其与放疗的联合已被试验用于不可切除Ⅲ期NSCLC的治疗。然而,放化疗后使用吉非替尼作为维持治疗的结果不容乐观。一项Ⅰ期试验评估了厄洛替尼与放化疗联合的疗效。放疗可通过损伤细胞膜、DNA以及微血管内皮细胞而诱导肿瘤死亡,而这反过来可增加促血管生成生长因子的产生。抗血管生长制剂可降低血管密度,但可改善肿瘤的含氧量。应用血管内皮生长因子受体(vascular endothelial growth factor receptor,VEGFR)抑制剂可通过阻断亚致死量辐射损伤的修复而增强放疗对人NSCLC的疗效。厄洛替尼、贝伐珠单抗与胸部放疗联合试验正在进行中。该三种药物联合治疗的新策略尚需制订。由于放疗可增强HSP90分子伴侣的功能从而引起肺癌细胞的放疗抵抗,此通路的阻断剂可通过抑制HIF-1a和VEGF的表达进而抑制肺癌细胞的生存和血管生成,因而可能用于减少放疗抵抗。在NSCLC和间皮瘤的临床前模型中,Aurora激酶抑制剂似乎对放疗具有增效作用。 | Mariano PROVENCIO Antonio SANCHEZ Pilar GARRIDO Francisco VALCARCEL 丁燕 李军 | 2010 | 中国肺癌杂志2010，，8： | 6 |
| 3 | Worldwide long-distance dispersal favored by epizoochorous traits in the biogeographic history of Omphalodeae (Boraginaceae)显示文摘Biogeographic dispersal is supported by numerous phylogenetic results.In particular,transoceanic dispersal,rather than vicariance,is suggested for some plant lineages despite current long distances between America and Europe.However,few studies on the biogeographic history of plants have also studied the role of diaspore syndromes in long-distance dispersal(LDD).Species of the tribe Omphalodeae(Boraginaceae)offer a suitable study system because the species have a wide variety of diaspore traits related to LDD and different lineages conform to patched worldwide distributions on three distant continents(Europe,America and New Zealand).Our aim is to reconstruct the biogeographical history of the Omphalodeae and to investigate the role of diaspore traits favoring LDD and current geographic distributions.To this end,a time-calibrated phylogeny with 29 of 32 species described for Omphalodeae was reconstructed using biogeographical analyses(BioGeoBEARS,Lagrange)and models(DEC and DIVA)under different scenarios of land connectivity.Character-state reconstruction(SIMMAP)and diversification rate estimations of the main lineages were also performed.The main result is that epizoochorous traits have been the ancestral state of LDD syndromes in most dades.An early diversification age of the tribe is inferred in the Western Mediterranean during late Oligocene.Colonization of the New World by Omphalodeae,followed by fast lineage differentiation,took place sometime in the Oligocene-Miocene boundary,as already inferred for other angiosperm genera.In contrast,colonization of remote islands(New Zealand,Juan Fernandez)occurred considerably later in the Miocene-Pliocene boundary. | Ana Otero Pedro Jimenez-Mejias Virginia Valcarcel Pablo Vargas | 2019 | Journal of Systematics and Evolution2019，57，6： | 3 |
| 4 | Plasma vitamins, amino acids, and renal function in postexercise hyperhomocysteinemia 显示文摘 | VENTA R CRUZ E VALCARCEL G | 2009 | Med Sci Sports Exerc2009，41，8： | 1 |
| 5 | Deployable Cover on a Swimming Pool in Seville显示文摘 | Escrig F Valcarcel J P Sanehe Z J | 1996 | Journal of the International Association for Shell and Spatial Structures1996，37，1： | 1 |
| 6 | Outcomes and Patient Satisfaction After Presbyopic Bilateral Lens Exchange with the ReSTOR IOL in Emmetropic Patients显示文摘 | Alfonso JF Fernandez-- Vega L Valcarcel B | 2010 | Cataract Refract Surg2010，1，28： | 1 |
| 7 | Supercritical fluid extraction of t-resveratrol and other phenolics from a spiked solid 显示文摘 | TENA M T Ri OS A VALCaRCEL M | 1998 | Fresenius J Anal Chem1998，361，： | 1 |
| 8 | Building specificity with nonspecific RNA-bind-ing proteins显示文摘 | Singh R Valcarcel J | | 0，，09： | 1 |
| 9 | Self-assembled monolayer- based piezoelectric flow immunosensor for the determination of canine immunoglobulin 显示文摘 | Arce L Zougagh M Arce C Moreno A Rios A Valcarcel M | 2007 | Biosensors and Bioelectronics2007，22，12： | 1 |
| 10 | Alternative splicing and genome complexity 显示文摘 | Brett D Pospisil H Valcarcel J | 2002 | Nat Genet2002，30，1： | 1 |
| 11 | Direct determination of biogenic amines in wine by integrating continuous flow clean-up and capillary electrophoresis with indirect UV detection显示文摘 | Arce L Rios A Valcarcel M | 1998 | J Chromatogr A1998，803，： | 1 |
| 12 | The hyaluronic acid receptor (CD44) is expressed in bovine oocytes and preimplantational stage embryos显示文摘 | Valcarcel A de Matos D G Furnus C C | 1999 | Theriogenology1999，51，： | 1 |
| 13 | Flow injection-capillary electrophoresis coupling to automate on-line sample treatment for the determination of inorganic ions in waters 显示文摘 | Arce L Rlos A Valcarcel M | 1997 | J Chromatogr A1997，791，： | 1 |
| 14 | Speciation of orga- nometallic compounds in environmental samples by gas chroma- tography after flow preconcentration on fullerenes and nanotubes 显示文摘 | MUNOZ J GALLEGO M VALCaRCEL M | 2005 | Anal Chem2005，，77： | 1 |
| 15 | Changes in sperm-bound amidase activity suggest subtle damage to ramsperm acrosomes by freezing/thawing, not detected by light microscopy显示文摘 | de Las Ileras M A Valcarcel A Furnus C | 1997 | Anita Reprod Scl1997，45，12： | 1 |
| 16 | Applications of supercritical fluid extraction in food analysis显示文摘 | valcarcel M Tena M T | 1997 | Fresenius J Ana Chem1997，，1997： | 1 |
| 17 | Indirect atomic absorptions pectrometric determination of perchlorate by liquid - liquid extraction in a flow - injection system显示文摘 | Gallego M Valcarcel M | 1985 | Analy ticaChem ical Acta1985，169，1： | 1 |
| 18 | Gas chromatographic flow method for the preconcentration and simultaneous determination of antioxidant and preservative additives in fatty foods显示文摘 | Gonzalez M Gallego M Valcarcel M | 1999 | J Chromatogr1999，848，12： | 1 |
| 19 | Supercritical fluid extraction of tea seed oil and its comparison with solvent extraction显示文摘 | Zougagh M Valcarcel M Rios A | 2005 | Eur Food Res Technol2005，220，： | 1 |
| 20 | Solid-phase extraction-gas chromatography-mass spectrometry using a fullerene sorbent for the determination of inorganic mercury( Ⅱ ), methylmercury( Ⅰ ) and ethylmercury( I ) in surface waters at subng/mL levels显示文摘 | MUNOZ J GALLEGO M VALCARCEL M | 2004 | J Chromatogr A2004，，1055： | 1 |
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