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| 1 | Alterations in the function of circulating mononuclear cells derived from patients with Crohn’s disease treated with mastic显示文摘AIM: To assess the effects of mastic administration on cytokine production of circulating mononuclear cells of patients with active Crohn's disease (CD). METHODS: The study was conducted in patients with established mildly to moderately active CD, attending the outpatient clinics of the hospital, and in healthy controls. Recruited to a 4 wk treatment with mastic caps (6 caps/d, 0.37 g/cap) were 10 patients and 8 controls, all of who successfully completed the protocol. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), macrophage migration inhibitory factor (MIF) and intracellular antioxidant glutathione (GSH) were evaluated in peripheral blood mononuclear cells (PBMC) before and after treatment. RESULTS: Treating CD patients with mastic resulted in the reduction of TNF-α secretion (2.1 ± 0.9 ng/mL vs 0.5 ± 0.4 ng/mL, P = 0.028). MIF release was signif icantly increased (1.2 ± 0.4 ng/mL vs 2.5 ± 0.7 ng/mL, P = 0.026) meaning that random migration and chemotaxis of monocytes/macrophages was inhibited. No signifi cant changes were observed in IL-6, MCP-1 and GSH concentrations. CONCLUSION: This study shows that mastic acts as an immunomodulator on PBMC, acting as a TNF-α inhibitor and a MIF stimulator. Although further double-blind, placebo-controlled studies in a large number of patients is required to clarify the role of this natural product, this f inding provides strong evidence that mastic might be an important regulator of immunity in CD. | Andriana C Kaliora Maria G Stathopoulou John K Triantaf illidis George VZ Dedoussis Nikolaos K Andrikopoulos | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | Chios mastic treatment of patients with active Crohn's disease显示文摘AIM: To evaluate the effectiveness of mastic administra-tion on the clinical course and plasma inflammatory me-diators of patients with active Crohn’s disease (CD).METHODS: This pilot study was conducted in patients with established mild to moderately active CD, attend-ing the outpatient clinics of the hospital, and in healthy controls. Ten patients and 8 controls were recruited for a 4-wk treatment with mastic caps (6 caps/d, 0.37 g/cap). All patients successfully completed the protocol. CD Ac-tivity Index (CDAI), Nutritional Risk Index (NRI), C-re-active protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), and total antioxidant potential (TAP) were evaluated in the plasma at baseline and at the end of the treatment period. Results were expressed as mean values ± SE and P < 0.05 was considered to indicate statistical significance.RESULTS: Patients exhibited significant reduction of CDAI (222.9 ± 18.7 vs 136.3 ± 12.3, P = 0.05) as com-pared to pretreament values. Plasma IL-6 was signifi-cantly decreased (21.2 ± 9.3 pg/mL vs 7.2 ± 2.8 pg/ mL, P = 0.027), and so did CRP (40.3 ± 13.1 mg/mL vs 19.7 ± 5.5, P = 0.028). TAP was significantly increased (0.15 ± 0.09 vs 0.57 ± 0.15 mmol/L uric acid, P = 0.036). No patient or control exhibited any kind of side effects. CONCLUSION: The results suggest that mastic signifi-cantly decreased the activity index and the plasma levels of IL-6 and CRP in patients with mildly to moderately ac-tive CD. Further double-blind, placebo-controlled studies in a larger number of patients are required to clarify the role of this natural product in the treatment of patients with CD. | Andriana C Kaliora Maria G Stathopoulou John K Triantafillidis George VZ Dedoussis Nikolaos K Andrikopoulos | 2007 | World Journal of Gastroenterology2007，13，5： | 7 |
| 3 | Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10显示文摘 | Folco EJ Rocha VZ Lopez-Ilasaca M | 2009 | J Biol Cbem2009，284，25： | 1 |
| 4 | Inflammation in athero-sclerosis:Transition from theory to practice显示文摘 | Libby P Okamoto Y Rocha VZ | | 0，，： | 1 |
| 5 | T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression 显示文摘 | Elena K Joseph D Mosca VZ | 2005 | J Biomed Sci2005，12，1： | 1 |
| 6 | Inflammation in atherosclerosis: transition from theory to practice 显示文摘 | Libby P Okamoto Y Rocha VZ | 2010 | Cite J2010，74，2： | 1 |
| 7 | Inflammation in atherosclerosis: transition from theory to practice 显示文摘 | Libby P Okamoto Y Rocha VZ | 2010 | Circ J2010，74，2： | 1 |
| 8 | Modeling of water and nitrogen balance in the ponded water of rice field显示文摘 | Antonopoulos VZ | 2008 | Paddy and Water Environment2008，6，： | 1 |
| 9 | The metabolism syndrome显示文摘 | Eckle RH Gmndy SM Zimmet VZ | 2005 | Lancet2005，365，9468： | 1 |
| 10 | The use of PTH in the treatment of osteoporosis显示文摘 | Borba VZ Maas NC | 2010 | Arq Bras Endocrinol Metabol2010，54，2： | 1 |
| 11 | Obesity, inflammation, and atherosclerosis 显示文摘 | Rocha VZ Libby P | 2009 | Nat Rev Cardiol2009，6，6： | 1 |
| 12 | Gold nanorods conjugated with doxorubicin and cRGD for combined anticancer drug delivery and PET imaging显示文摘 | Xiao Y Hong H Matson VZ | 2012 | Theranostics2012，2，： | 1 |
| 13 | HGF,MET,and matrix-related proteases in hepatocellular carcinoma,fibrolamellar variant,cirrlotic and normal liver显示文摘 | Schoedel KE Tyner VZ Kim TH | 2003 | Mod Pathol2003，16，1： | 1 |
| 14 | Neurovascular mechanisms of Alzheimer's neurodegen- eration 显示文摘 | Berislav VZ | 2005 | Trends Neurosci2005，28，： | 1 |
| 15 | Painful ophthalmoplegia with reversible carotid stenosis in a child 显示文摘 | Mireia DT Alfons MC Elida VZ | 2001 | Pediatr Neurol2001，24，4： | 1 |
| 16 | Erlotinib in advaneed non-small cell lung cancer: efficacy and safety findings of the global phase IV Tareeva Lung Cancer Survival Treatment study 显示文摘 | Martin R Nico VZ Cesare G | 2010 | J Thoruc Oncol2010，5，10： | 1 |
| 17 | HGF, MET, and matrix-related proteases in hepatocellular carcinoma, fibrolamellar variant, cirrhotic and normal liver显示文摘 | Schoedel KE Tyner VZ Kim TH | 2003 | Mod Patho12003，16，1： | 1 |
| 18 | Sonoluminiscence of blood plasma in the differential diagnosis of tuberculosis, cancer and sarcoidosis of the lungs显示文摘 | Zhadnov VZ Mishanov RF Chernov VV | 1994 | Probl Tuberk1994，6，1： | 1 |
| 19 | A systematic review and meta-analysis of randomized controlled trials of cognitive?behavioral therapy for tinnitus distress显示文摘 | Hesser H Weise C Westin VZ | 2011 | Clin Psychol Rev2011，31，4： | 1 |
| 20 | Low daily dose of antioxidant probucol decreases incidence and severity of restenosis after transluminal coronary balloon angioplasty显示文摘 | Kaminnyi AI Lankin VZ Samko AN | 2005 | Bull Exp Biol Med2005，139，2： | 1 |
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