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| 1 | Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study显示文摘AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care system.METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. | Cristina Stasi Caterina Silvestri Roberto Berni Maurizia Rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani | 2018 | World Journal of Hepatology2018，10，5： | 3 |
| 2 | A general enthalpy method for modeling solidification processes显示文摘 | Waminathan C R Voller V R | 1992 | Metall Trans B1992，23，： | 2 |
| 3 | Approximate models of microsegregation with coarsening 显示文摘 | Beckermann C | 1999 | Met and Mat Trans A1999，30，： | 1 |
| 4 | A fixed grid numerical modeling method-ology for convection-diffusion mushy region phase change prob-lems显示文摘 | Voller V R Prakash C | 1987 | Int J Heat Mass Tran1987，30，8： | 1 |
| 5 | Effects of brain po- larization on reaction times and pinch force in chronic stroke显示文摘 | Hummel FC Voller B Celnik P | 2006 | BMC Neurosci2006，，7： | 1 |
| 6 | Treatment of discontinuous thermal conductivity in control-volume solutions of phase-change problems 显示文摘 | Voller V R Swaminathan C R | 1993 | Numerical Heat Transfer : Part B1993，，24： | 1 |
| 7 | Aortic enlargenment and late reoperation after repair of acute type A aortic dissetion显示文摘 | ZIERER A VOLLER RK HILL KE | 2007 | Ann Thorac Sury2007，84，3： | 1 |
| 8 | Numerical treatment of rapidly changing and discontinuous conductivities显示文摘 | Voller V R | 2001 | International J of Heat and Mass Transfer2001，，44： | 1 |
| 9 | The modeling of heat, mass and solute transport in solidification systems显示文摘 | Voller V R Brent A D Prakash C | 1989 | International Journal of Heat and Mass Transfer1989，32，9： | 1 |
| 10 | Hypertrophic chronic pachymeningitis as a localized immune process in the craniocervical region显示文摘 | Voller B Vass K Wanschitz J | 2001 | Neurology2001，56，1： | 1 |
| 11 | Type of edema in posterior reversible encephalopathy syndrome depends on serum albumin levels: an MR imaging study in 28 patients显示文摘 | Pirker A Kramer L Voller B | 2011 | AJNR2011，32，： | 1 |
| 12 | Fast implicit finite difference method for the analysis of phase change problems 显示文摘 | Voller V R | 1990 | Numerical Heat Transfer Part B1990，17，2： | 1 |
| 13 | Left ventricular remodeling:pathophysiological mechanisms and therapeutic recommendations显示文摘 | Voller H Dietz R | 1999 | Z Kardiol1999，88，12： | 1 |
| 14 | Microplate enzyme-linked immunosorbent assay for Chagas disease显示文摘 | Voller A Draper CC Bidwell DE | 1975 | Lancet1975，1，： | 1 |
| 15 | A Fixed-Grid Numerical Modeling Methodology for Convection-Diffusion Mushy Region Phase- Change Problems显示文摘 | Voller V R and Prakash C | 1987 | Heat Mass Transfer1987，30，： | 1 |
| 16 | A fixed grid numerical modeling methodology for convection2diffusion mushy region phase-change problems 显示文摘 | VOLLER V R PRAKASH C | 1987 | Int J Heat Mass Transfer1987，30，8： | 1 |
| 17 | An Algorithm for Analysis of Polymer Filling of Molds 显示文摘 | Voller V R Peng S | 1995 | Polymer Engineering and Science1995，35，22： | 1 |
| 18 | A numerical scheme for solidification of an alloy显示文摘 | | 1998 | Canadian Metallurgical Quarterly1998，37，34： | 1 |
| 19 | A Fixed grid numerical modelling methodology for convection-diffusion mushy region phase-change problems 显示文摘 | Voller V R | 1987 | Int J Heat Mass Transfer1987，30，8： | 1 |
| 20 | An explicit scheme for tracking the filling front during polymer mold filling 显示文摘 | LUOMA J A VOLLER V R | 2000 | Appl Math Modelling2000，24，89： | 1 |
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