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| 1 | Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin. | Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen | 2011 | World Journal of Gastroenterology2011，17，26： | 2 |
| 2 | Performance on a measure of category fluency in cognitively impaired elderly 显示文摘 | Hall J R Harvey M Vo H T | 2011 | Neuropsychol Dev Cogn B Aging Neuropsychol Cogn2011，18，3： | 1 |
| 3 | Levels of Expression of P-Selectin, E-Selectin, and Intercellular Adhesion Molecule-1 in Coronary Atherectomy Specimens from Patients With Stable and Unstable Angina Pectoris显示文摘 | Alan N Tenaglia MD Andrew J Buda MD Robert G Wilkins MD Michael K Barron MD Paul R Jeffords BS Khoa Vo BS Maureen O Jordan BS Barry A Kusnick MD David J Lefer PhD | 1997 | The American Journal of Cardiology1997，，6： | 1 |
| 4 | Container terminal operation and operations research : A classification and literature review 显示文摘 | Steenken D Voβ S Stahlbock R | 2004 | OR Spectrum2004，26，1： | 1 |
| 5 | Investigation of the effects of peppermint oil and valerian on rat liver and cultured human liver cells显示文摘 | Vo L T Chan D King R G | 2003 | Clin Exp Pharmacol Physiol2003，30，10： | 1 |
| 6 | Human nucleus pulposus cells react to IL-6:independent actions and amplification of response to IL-1 and TNF-α显示文摘 | Studer R K Vo N Sowa G | 2011 | Spine2011，36，8： | 1 |
| 7 | Container Terminal Operation and Operations Research-A Classification and Literature Review 显示文摘 | Steenken D Voβ S Stahlbock R | 2004 | OR Spectrum2004，26，1： | 1 |
| 8 | A mathematical model for pulsatile release: controlled release ofrhodamine B from UV- crosslinked thermoresponsive thin films 显示文摘 | Yang R Vo T Gorelov AV | 2012 | Int J Pharm2012，427，2： | 1 |
| 9 | Biogenic Methane Potential for Surat Basin, Queensland Coal Seams 显示文摘 | Papendick S L Downs K R Vo K D | 2011 | International Journal of Coal Geology2011，88，23： | 1 |
| 10 | Measurement of the lattice misfit in the single crystal nickel based superalloys CMSX-4, SRR99 and SC16 by convergent beam electron diffraction显示文摘 | Vo lkl R Glatzel U Feller- Kniepmeier M | 1998 | Acta Materialia1998，46，12： | 1 |
| 11 | Forward-backward probability hypothesis density smoothing 显示文摘 | Mahler R P S Vo B T Vo B N | 2012 | IEEE Transaction on Aerospace and Electronic Systems2012，48，1： | 1 |
| 12 | Container terminal opera- tion and operations research-a classification and literature re- view 显示文摘 | Steenken D Voβ S Stahlbock R | 2004 | OR Spectrum2004，26，1： | 1 |
| 13 | Yield strength in nanocrystalline Cu during high strain rate deformation显示文摘 | VO N Q AVERBACK R S BELLON P | 2009 | ScriptaMaterialia2009，61，1： | 1 |
| 14 | Lack of mutagenic activity of 1,6-hexamethylene diisocyanate显示文摘 | SAN RH GUDI R | 2000 | Toxicol Sci2000，55，2： | 1 |
| 15 | Operations research at container termi-nals: a literature update 显示文摘 | Stahlbock R Voβ S | 2008 | OR Spectrum2008，30，1： | 1 |
| 16 | Familiality of kid- ney stone disease inlceland 显示文摘 | Edvardsson VO Palsson R Indridason OS | 2009 | Scand JUrot Nephrol2009，43，5： | 1 |
| 17 | Container terminal operation and operations research- a classification and literature review显示文摘 | Steenken D Vo? S Stahlbock R | 2004 | OR Spectrum2004，26，1： | 1 |
| 18 | CPHD filtering with unknown clutter rate and detection profile 显示文摘 | Mahler R Vo B-T Vo B-N | 2011 | IEEE Transactions on Signal Processing (S 1053-587X)2011，59，8： | 1 |
| 19 | Operations research at container terminals: a literature update显示文摘 | Stahlbock R Vo? S | 2008 | OR Spectrum2008，30，1： | 1 |
| 20 | Human nucleus pulposus cells re- act to IL-6 : independent actions and amplification of response to IL-1 and TNF-α 显示文摘 | Studer R K Vo N Sowa G | 2011 | Spine2011，36，8： | 1 |
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