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11篇 您的检索式:作者名="VOS M R"
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1Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin.Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen 2011World Journal of Gastroenterology2011,17,26:2
2Performance on a measure of category fluency in cognitively impaired elderly 显示文摘Hall J R Harvey M Vo H T 2011Neuropsychol Dev Cogn B Aging Neuropsychol Cogn2011,18,3:1
3Measurement of the lattice misfit in the single crystal nickel based superalloys CMSX-4, SRR99 and SC16 by convergent beam electron diffraction显示文摘Vo lkl R Glatzel U Feller- Kniepmeier M 1998Acta Materialia1998,46,12:1
4Mesenchymal stem cells within tumour stroma promote breast cancer metastasis显示文摘KARNOUB A DASH A VO A SULLIVAN A BROOKS M BELL G RICHARDSON A POLYAK K TUBO R WEINBERG R 2007Nature2007,449,7162:1
5p38 MAPK inhibition in nucleus pulposus cells: a potential target for treating intervertebral disc degeneration显示文摘Studer R K Aboka A M Gilbertson L G Georgescu H Sowa G Vo N 2007Spine2007,32,:1
6Characterization of homo- typic and heterotypic VP7 neutralization sites of rhesus rotavirus显示文摘Mackow E R Shaw R D Matsui S M Vo P T Ben- field D A Greenberg H B 1988Virology1988,165,2:1
7Temporal artery biopsy for giant cell arteritis显示文摘Taylor-Gjewe R Vo M Shukla D 2005J Rheumatol2005,32,7:1
8SLAM gets a PHD: new concepts in map estimation 显示文摘ADAMS M VO B N MAHLER R 2014IEEE Robotics and Automation Magazine2014,21,2:1
9Temporal artery biopsy for giant cell arteritis显示文摘 Vo M Shukla D 2005J Rheumatol2005,32,:1
10Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance显示文摘 Béclin C Elmayan T Feuerbach F Godon C Mortl J-B Jouette D Lacombe A-M Nikic S Picault N Rémoué K Sanial M Vo T-A Vaucheret H 2000Cell2000,101,:1
11The value of the world' s ecosystem services and natural capi- tal 显示文摘Costanza R d' Arge R de Groot R Farber S Grasso M Hannon B Limburg K Naeemg S VO' Neill R Paruelod G'Roskin R Sutton P vanden Beltu M 1997Nature1997,387,:1
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