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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Prognostic significance of tissue type plasminogen activator content in gastric cancer and surrounding mucosa显示文摘 | Sanz L Vizoso F Verez P | 2002 | Int J Boil Markers2002，17，： | 1 |
| 3 | Clinical significance of theepidermal growth factor receptor and HER-2receptor inresectable gastric cancer显示文摘 | Garcia I Vizoso F Martin A | 2003 | Ann Surg Oncol2003，10，3： | 1 |
| 4 | Prognostic significance of cytosolic PS2 protein content in gastric cancer 显示文摘 | Suarez C Vizoso F Rodriguez JC | 2001 | Int J Biol Markers2001，16，1： | 1 |
| 5 | Mechanisms of primordium formation during adventitious root development from walnut cotyledon explants显示文摘 | Ermel F F Vizoso S Charpentier J P | 2000 | Planta2000，211，4： | 1 |
| 6 | Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastic cancer 显示文摘 | Garcia I Vizoso F Martin A | 2003 | Ann Surg Oncol2003，10，3： | 1 |
| 7 | Mechanisms of primordium formation during adventitious root development from walnut cotyledon explants显示文摘 | Ermel F F Vizoso S Charpentier J P | 2000 | Planta2000，211，4： | 1 |
| 8 | Clinical significance of the epidermal growth factor receptor and HER-2 receptor in respectable gastric cancer显示文摘 | Garcia I Vizoso F Martin A | 2003 | Ann Surg Oncol2003，10，3： | 1 |
| 9 | Study ofmatrix metallop roteinases and their inhibitors in breast cancer显示文摘 | Vizoso F J Gonzalez L O Corte M D | 2007 | Br J Cancer2007，96，6： | 1 |
| 10 | Mechanisms of primordium formation during adventitious root development from walnut cotyledon explants 显示文摘 | ERMEL1 F F VIZOSO S CHARPENTIER J P | 2000 | Plartta2000，211，： | 1 |
| 11 | Clinical significance of epidermal growth factor receptor content in gastric cancer显示文摘 | Garcia I Vizoso F Andicoechea A | 2001 | Int J Biol Markers2001，16，3： | 1 |
| 12 | Expression and prognostic significance of pepsinogen C in gastric carcinoma显示文摘 | Ferna'ndez R Vizoso F Rodriguez JC | 2000 | Annals Surg Oncol2000，7，7： | 1 |
| 13 | Expression and prognostic significancce of lysozyme in male breast cancer显示文摘 | Seno C Vizoso F Alonso L | 2002 | Breast Cancer Res2002，4，6： | 1 |
| 14 | Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastric cancer 显示文摘 | Garcia I Vizoso F Martin A | 2003 | Ann Surg Oncol2003，10，3： | 1 |
| 15 | Apolipoprotein D expression in cutaneous malignant melanoma显示文摘 | Miranda E Vizoso F Martin A | 2003 | J Surg Oncol2003，83，2： | 1 |
| 16 | Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastric cancer 显示文摘 | Garcia I Vizoso F Martin A | 2003 | Ann Surg Onco2003，10，3： | 1 |
| 17 | Hyaluro-nic acid as prognostic marker in resectable colorectal cancer 显示文摘 | VIZOSO F RODRIGUEZ J C | 2000 | Br J Surg2000，87，12： | 1 |
| 18 | Mechanisms of primordium formation during adventitious root development from walnut cotyledon explants显示文摘 | ERMEL F F VIZOSO S CHARPENTIER J P | 2000 | Planta2000，211，4： | 1 |
| 19 | Expression and prognostic significance of pepsinogen C in gastric carcinoma显示文摘 | Fernandez R Vizoso F Rodriguez JC | 2000 | Ann Surg Oncol2000，7，7： | 1 |
| 20 | Expression and prognostic significance of lysozyme in male breast cancer 显示文摘 | Serra C Vizoso F Alonso L | 2002 | Breast Cancer Res2002，4，6： | 1 |
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