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| 1 | Targeting natural killer cells in solid tumors显示文摘Natural killer(NK)cells are innate lymphoid cells endowed with cytolytic activity and a capacity to secrete cytokines and chemokines.Several lines of evidence suggest that NK cells play an important role in anti-tumor immunity.Some therapies against hematological malignacies make use of the immune properties of NK cells,such as their ability to kill residual leukemic blasts efficiently after conditioning during haploidentical hematopoietic stem cell transplantation.However,knowledge on NK cell infiltration and the status of NK cell responsiveness in solid tumors is limited so far.The pro-angiogenic role of the recently described NK cell-like type 1 innate lymphoid cells(ILC1s)and their phenotypic resemblance to NK cells are confounding factors that add a level of complexity,at least in mice.Here,we review the current knowledge on the presence and function of NK cells in solid tumors as well as the immunotherapeutic approaches designed to harness NK cell functions in these conditions,including those that aim to reinforce conventional anti-tumor therapies to increase the chances of successful treatment. | Guillaume Habif Adeline Crinier Pascale Andre Eric Vivier Emilie Narni-Mancinelli | 2019 | Cellular & Molecular Immunology2019，16，5： | 9 |
| 2 | Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor cells.Among human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and NK2.Using the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone marrow.Pseudotime analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological conditions.Transcriptomic profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell heterogeneity.Bone marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，5： | 5 |
| 3 | 大巴黎区的城市公交与小汽车交通的外部成本比较显示文摘 | Jean Vivier 李枫 | 2000 | 城市轨道交通研究2000，3，1： | 2 |
| 4 | Barium vanadium pentoxide-based compounds prepared via a sol-gel process and their evaluation as lithium intercalation materials显示文摘 | Vivier V Baddour-Hadjean R Pereira-Ramos J P | 1998 | J Mater Chem1998，8，： | 1 |
| 5 | A quantitative treatment planning study evaluating the potential of dose escallation conformal radiotherapy of the oesophagus显示文摘 | Bedford JL Viviers L Guzel Z | 2000 | Radiother Oncol2000，57，2： | 1 |
| 6 | Enhancing a Competitive Intelligence Culture in South Africa显示文摘 | Wilma Viviers andrea Saayman Mari6-Luce Muller | 2005 | International Journal of Social Economics2005，32，7： | 1 |
| 7 | A quantitative treatment planning study evaluating the potential of dose escalation in conformal radiotherapy of the oesophagus显示文摘 | Bedford JL Viviers L Guzel Z | 2000 | Radiother Oneol2000，57，2： | 1 |
| 8 | Analysis of the transitionfrom oral polio vaccine to inactivated polio vaccine for primary immunizationin a hospital-based primary care practice显示文摘 | Lakhiani CN Vivier PM Alario AJ | 2000 | Pediatr Infect Dis J2000，19，6： | 1 |
| 9 | Innate or adaptive immu- nity? The example of natural killer cells 显示文摘 | Vivier E Raulet DH Moretta A | 2011 | Science2011，331，6013： | 1 |
| 10 | The contributions of wind forcing waves and surface heating to sea surface height observations in the Pacific Ocean 显示文摘 | Vivier F Kelly K A Thompson L | 1999 | J Geophys Res1999，104，20： | 1 |
| 11 | Natural killer cell signal- ing pathways显示文摘 | Vivier E Nunes JA Vely E | 2004 | Science2004，30，6： | 1 |
| 12 | Risks and routes for Ventilator-associated pneumonia in ICU patients 显示文摘 | Bergmans J L Viviers L Guzel Z | 2002 | Hosp Infecl2002，53，： | 1 |
| 13 | Cushing5s syndrome due to agastric inhibitory polypeptide-dependent adrenal adenoma: insightsinto hormonal control of adrenocortical tumorigenesis显示文摘 | Chabre O Liakos P Vivier J | 1998 | ClinEndocrinol Metab1998，83，9： | 1 |
| 14 | Contributions of wind forcing, waves, and surface heating to sea surface height observations in the Pacific Ocean 显示文摘 | VIVIER F | 1999 | Journal of Physical Oceanography1999，104，20： | 1 |
| 15 | Hydrogenation ofolefins over hydrotreating catalysts promotion effect on the activity and on the involvement of H2S in the reaction 显示文摘 | Br6maud M Vivier L P6rot G | 2005 | Applied Catalysis2005，289，： | 1 |
| 16 | Phase II study of primary temozolomide chemotherapy in patients with WHO grade II gliomas 显示文摘 | Brada M Viviers L Abson C | 2003 | Ann Oncol2003，14，： | 1 |
| 17 | Deuterium tracerstudies on hydrotreating catalysts-isotopic exchange betweenhydrogen and hydrogen sulfide on sulfided NiMo/Al2O3显示文摘 | Thomas C Vivier L Lemberton J L | 1997 | J Catal1997，167，1： | 1 |
| 18 | Natural killer cells:adaptation and memory in innate immunity显示文摘 | Narni-Mancinelli E Ugolini S Vivier E | 2013 | Med Sci(Paris)2013，29，4： | 1 |
| 19 | Functions of natu- ral killer cells显示文摘 | Vivier E Tomasello E Baratin M | 2008 | Nat Immunol2008，9，5： | 1 |
| 20 | Chronic obstructive pulmonary disease--diagnosis and classification of severity显示文摘 | Viviers P J van Zyl-Smit R N | 2015 | S Afr Med J2015，105，9： | 1 |
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