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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | NIR spectroscopy:a rapid-response analytical tool显示文摘 | Blanco M Villarroya I | 2002 | Trends in Analytical Chemistry2002，21，4： | 1 |
| 3 | NIR spectroscopy: a rapid-response analytical tool显示文摘 | Blanco M Villarroya I | 2002 | Trends in analytical chemistry2002，21，4： | 1 |
| 4 | NIR spectroscopy: a rapid-response analytical tool显示文摘 | Blanco M Villarroya I | 2002 | Trends in Analytical Chemistry2002，21，4： | 1 |
| 5 | NIR spectroscopy: a rapid-response analytical tool显示文摘 | Blanco M Villarroya I | 2002 | Trends in Analytical Chemistry2002，21，4： | 1 |
| 6 | Unidirectional transfer of microRNA-loaded exosomesfrom T cells to antigen-presenting cells 显示文摘 | MITTELBRUNN M GUTIERREZ V C VILLARROYA B C | 2011 | Nat Commun2011，2，4： | 1 |
| 7 | NIR spectroscopy:a rapid-response analytical tool显示文摘 | BLANCO M VILLARROYA I | 2002 | Trends in analytical chemistry2002，21，4： | 1 |
| 8 | Retinoids and adipose tissue: Metabolism, cell differentiation and gene expression显示文摘 | Villarroya F Giralt M Iglesias R | 1999 | Int J Obes Relat Metab Disord1999，23，： | 1 |
| 9 | NIR spectroscopy: a rapid-response analytical tool显示文摘 | M. Blanco I. Villarroya | 2002 | Trends in Analytical Chemistry2002，，4： | 1 |
| 10 | Quantification and localization of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during experimental allergic encephalomyelitis in the rat显示文摘 | Pilar Calvol Bruno Gouritin Henri Villarroya | 2002 | European J of Neuroscience2002，15，： | 1 |
| 11 | Quantification and localization of PEGylated polycyanoacylate nanoparticlcs in brain and spinal cord daring experimental allergic encephalomyelitis in the rat显示文摘 | Calvo P Gouritin B Villarroya H | 2002 | Ear J Neurosci2002，15，8： | 1 |
| 12 | NIR spectroscopy:a rapid-response analytical tool显示文摘 | Blanco M Villarroya I | 2002 | TrAC Trends in Analytical Chemistry2002，21，4： | 1 |
| 13 | Irisin, turning up the heat显示文摘 | Villarroya F | 2012 | Cell Metab2012，15，3： | 1 |
| 14 | Anesthesia for carbon dioxide laser surgery to correct Zenker s diverticulum显示文摘 | Izquierdo Villarroya B Hernandez Montero E Martinez Ubieto J | 2004 | Rev Esp Anestesiol Reanim2004，51，5： | 1 |
| 15 | Assessment of the me-dial longitudinal arch in children and adolescents with obesity:foot-prints and radiographic study显示文摘 | Villarroya MA Esquivel JM Tornas C | 2009 | Eur J Pediatr2009，5，： | 1 |
| 16 | Sustainable management ofgroundwater resources 显示文摘 | Villarroya F Aid well C R | 1998 | Environmental Geology1998，34，23： | 1 |
| 17 | Irisin, turning up the heat显示文摘 | Villarroya F | 2012 | Cell Metab2012，15，3： | 1 |
| 18 | , Cantilever based MEMS for multiple mass sensing 显示文摘 | Maria Villarroya Jaume Verd etc | 2005 | Researching in Microelectronies and Electronics2005，，1： | 1 |
| 19 | NIR Spectroscopy:A Rapid-Response Analytical Tool显示文摘 | Blanco M Villarroya I | 2002 | Trends in Analytical Chemistry2002，21，4： | 1 |
| 20 | Research trends in gender differences in higher education and science: a co-word analysis显示文摘 | Dehdarirad T Villarroya A Barrios M | 2014 | Scientometrics2014，101，1： | 1 |
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