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| 1 | Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?显示文摘Chronic hepatitis B(CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue(NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus(HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen(HBs Ag), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBs Ag loss. The results have indicated that the majority of patients can remain off therapy, with some even reaching HBs Ag seroconversion. Fortunately, this strategy has proved to be safe, but it is essential to consider the risk of liver damage and other comorbidities and to ensure aclose follow-up of the candidates before considering this strategy. Unanswered questions remain, namely in which patients could this strategy be effective and what is the optimal time point at which to perform it. To solve this enigma, we should keep in mind that the outcome will ultimately depend on the equilibrium between HBV and the host's immune system. Viral parameters that have been described as good predictors of response in HBe Ag(+) cases, have proven useless in HBe Ag(-) ones. Since antiviral immunity plays an essential role in the control of HBV infection, we sought to review and explain potential immunological biomarkers to predict safe NA discontinuation in both groups. | Elia Moreno-Cubero Robert T Sánchez del Arco Julia Pena-Asensio Eduardo Sanz de Villalobos Joaquín Míquel Juan Ramón Larrubia | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 2 | Spatially resolved characterization of biogenic manganese oxide production within a bacterial biofilm显示文摘 | Toner B Fakra S Villalobos M | 2005 | Applied and Environmental Microbiology2005，71，3： | 1 |
| 3 | Does shaking alter the time of hatching in incubated medaka (Oryzias latipes) embryos 显示文摘 | Gonzalez D M Villalobos S A Okihiro M S et d | 2004 | Bulletin of Environmental Contamination and Toxicology2004，73，2： | 1 |
| 4 | A family of thermostable fungal cellulases created by structure-guided recombination 显示文摘 | Heinzelman P Snow CD Wu I Nguyen C Villalobos A Govindarajan S Minshull J Arnold FH | 2009 | PNAS2009，106，： | 1 |
| 5 | A three- dimensional approach to school typology using vertical scanning multibeam sonar 显示文摘 | PARAMO J BERTRAND S VILLALOBOS S | 2007 | Fisheries Research2007，84，： | 1 |
| 6 | Soil evaporation from drip-irrigated olive orchards显示文摘 | Bonachela S Orgaz F Villalobos F J | 2001 | Irrigation Science2001，20，2： | 1 |
| 7 | Thiobencarb-induced embryotoxicity in medaka (Oryzias latipes):stage-specific toxicity and the protective role of chorion显示文摘 | VILLALOBOS S A HAMM J T TEH S J | 2000 | Aquatic Toxicology2000，48，23： | 1 |
| 8 | Pa- raquat-induced Oxidative Stress in Drosophila melano- gaster : Effects of Medlatonin, Glutathione, Serotonin, Mi- nocycline, Lipoic Acid and Ascorbic Acid 显示文摘 | Bonilla E Medina-Leendertz S Villalobos V | 2006 | Neuro- chem Res2006，31，12： | 1 |
| 9 | A three- dimensional approach to school typology using vertical scanning muhibeam sonar 显示文摘 | PARAMO J BERTRAND S VILLALOBOS H | 2007 | Fisheries Research2007，84，： | 1 |
| 10 | Effect of the drug-excipient ratio in matrix-type-controlled release systems:computer simulation study 显示文摘 | VILLALOBOS R GANEM A CORDERO S | 2005 | Drug Dev Ind Pharm2005，31，6： | 1 |
| 11 | Association of HLA class I and leukemia in mestizo patients of the state of Zulia, Venezuela 显示文摘 | Villalobos C Rivera S Weir-Medina J | 2003 | Invest Clin2003，44，4： | 1 |
| 12 | Elevated epidermal growth factor receptor phosphorylation induces resist ance artery dysfunction in diabetic db/db mice 显示文摘 | Belmadani S Palen DI Gonzalez Villalobos RA | 2008 | Diabetes2008，57，6： | 1 |
| 13 | Searching for biosignatures using electron pammagnetic resonance (EPR) analysis of manganese oxides 显示文摘 | Kim S S Bargar J R Nealson K H Flood B E Kirschvink J L Raub T D Tebo B M Villalobos M | 2011 | Astrobiology2011，11，8： | 1 |
| 14 | Transformation of tobacco with an arabidopsis thaliana gene involvedin trehaJose biosynthesis increases tolerance to several abiotic stresses 显示文摘 | Almeida A M Villalobos E Arafijo S S Leyman B Dijck P V Alfaro-Cardoso L Fevereiro PS Torn6 J M Santos D M | 2005 | Euphytica2005，146，16： | 1 |
| 15 | Respiratory acoustic thoracic imaging(RATHI) : assessing deterministic interpola- tion techniques显示文摘 | Charleston - Villalobos S Cortes - Rubiano S Gonza- lee-Camarena R | 2004 | Med Biol Eng Comput2004，42，： | 1 |
| 16 | Effect of Waterborne Exposure to 4-Nonylphenol on Plasma Sex Steroid and ViteUgenin Concentrations in Sexually Mature Male Carp (Cyprinuscarpio)显示文摘 | VILLENEUVE D L VILLALOBOS S A KEITY T L | 2002 | Chemophere2002，47，1： | 1 |
| 17 | Benign symmetric lipomatosis of the tongue in Madelung's disease显示文摘 | Lopez-Ceres A Aguilar-Lizarralde Y Villalobos Sánchez A | 2006 | J Craniomaxillofac Surg2006，34，8： | 1 |
| 18 | The eachchild study: systematic screening for autism spectrumdisorders in a pediatric setting 显示文摘 | Miller J S Gabrielsen T Villalobos M | 2011 | Pediatrics2011，127，5： | 1 |
| 19 | Spatially Resolved Characterization of Biogenic Manganese Oxide Production within a Bacterial Biofilm 显示文摘 | TONER B FAKRA S VILLALOBOS M | 2005 | Appl Environ Microbiol2005，71，3： | 1 |
| 20 | Morpho- logical effects Of bisphenol-A on the early life stages of medaka (Oryzias latipes) 显示文摘 | Pastva S D Villalobos S A Kannan K | 2001 | Chemosphere2001，45，45： | 1 |
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