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| 1 | Insulin sensitizers in treatment of nonalcoholic fatty liver disease:Systematic review显示文摘AIM: To summarize the evidence available for the clinical effectiveness of insulin sensitizers in the treatment of nonalcoholic fatty liver disease (NAFLD) systematically. METHODS: Relevant articles were located using computer-assisted searches of Medline (1966-March 2006), EMBASE (1988-March 2006), CINAHL (1982-March 2003), Educational Resource Information Center (1966-March 2006), Library, Information Science & Technology Abstracts (1967-March 2006), Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects (1994-2006), dissertations in ProQuest and FirstSearch databases. Manual searches were made in the abstracts from meetings of the American Gastroenterological Association (1999-2006), and the American Association for the Study of Liver Diseases (2003-2005). Studies were retrieved using the following selection criteria: (1) clinical trials using insulin sensitizers in subjects with NAFLD, (2) adult patients, (3) published as full manuscripts or abstracts, and (4) English, Spanish, German, and French languages only. Data were abstracted independently by two reviewers following standardized procedures. A face-to- face comparison of data was conducted to ensure the completeness and reliability of the abstraction process. RESULTS: Nine studies were included, six using metformin and three using thiazolidinediones. Only two studies were placebo-controlled trials. The mediansample size for all studies was 18 subjects. In the placebo-controlled trials, metformin improved insulin resistance markers and liver function tests, but not histological scores. In the single-arm trials, metformin and thiazolidinediones improved insulin resistance markers and liver function tests, and beneficial histological changes were reported. There is limited high-quality information available from which to draw categorical conclusions about the clinical use of insulin sensitizers in NAFLD.CONCLUSION: Current information indicates that the use of insulin sensitizers in NAFLD improves insulin resistance and liver function. Histological changes must be corroborated in randomized controlled trials. | Norberto C Chavez-Tapia Tonatiuh Barrientos-Gutierrez Felix I Tellez-ávila Francisco Sánchez-ávila Maria Antonieta Montao-Reyes Misael Uribe | 2006 | World Journal of Gastroenterology2006，12，48： | 11 |
| 2 | Increased lysophosphatidylcholine and non-esterified fatty acid content in LDL induces chemokine release in endothelial cell:Relationship with electronegative LDL显示文摘 | Benitez S Camacho M Arcelus R Vila L Bancell C Ordonez-Llanos J | 2004 | Atherosclerosis2004，177，2： | 1 |
| 3 | Widespread origins of domestic horse lineages显示文摘 | VILA C LEONARD J A GOTHERSTROM A | 2001 | Science2001，291，5503： | 1 |
| 4 | Effects of the river discharge management on the nursery function of the Guadalquivir river estuary (SW Spain) 显示文摘 | DELGADO C F BALDO F VILAS C | 2007 | Hydrobiologia2007，587，1： | 1 |
| 5 | Mitochondria and programmed ceil death in Parkinson' s disease: apoptosis and beyond显示文摘 | Perier C Bove J Vila M | 2012 | Antioxid Redox Signal2012，16，9： | 1 |
| 6 | Comparison of positron emission tomography (PET)and computed tomo-graphy(CT) for better target volume deft nition in radiation therapy planning 显示文摘 | Vila A S6nchez-Reyes A Conill C | 2010 | Clin Transl Oncol2010，12，5： | 1 |
| 7 | Recovery of lignin and furfural from acetic acid water-HCl pulping liquors 显示文摘 | Vila C Santos V Parajo J C | 2003 | Bioresource Technology2003，90，3： | 1 |
| 8 | Psychopathology and quality of life for adolescents with asthma and their parents显示文摘 | Vila G Hayder R Bertrand C | 2003 | Psychoso- matics2003，44，4： | 1 |
| 9 | Impulse control disor- ders in Parkinson's disease 显示文摘 | Vilas D Pont-Sunyer C Tolosa E | 2012 | Parkinsonism Relat Dis- ord2012，18，1： | 1 |
| 10 | Endovascular reconstruction by means of stent placement in symptomatic intracranial atherosclerotic stenosis显示文摘 | Lylyk P Vila JF Miranda C | 2005 | Neurol Res2005，，： | 1 |
| 11 | Endocarditis due to Corynebacterium pseudodiphtheriticum显示文摘 | Rivero M Quereda C Martín-Dávila P | 2003 | Enferm Infecc Microbiol Clin2003，21，2： | 1 |
| 12 | Optimization of Water Supply Operation显示文摘 | Vilas Nitivattananon Elaine C Sadowski Rafael G Qunimpo | 1996 | Water Resources Planning and Management1996，122，5： | 1 |
| 13 | L-3-hydroxyacyl-CoA dehydrogenase Ⅱ protects in a model of Parkinson's disease显示文摘 | Tieu K Perier C Vila M | 2004 | Ann Neurol2004，56，1： | 1 |
| 14 | Plasma homocysteine level in patients with ischemic cerebral infarction显示文摘 | Vila N Deulofeu R Chamorro A Piera C | 1998 | Med Clin (Barc)1998，110，16： | 1 |
| 15 | Macrolides asthma, inflammation, and infection 显示文摘 | Vila P C Boushey H A | 2000 | Ann Allergy Asthma hnmunol2000，84，6： | 1 |
| 16 | Optical and magnetic properties of CuO nanowires grown by thermal oxidation显示文摘 | Vila M Díaz-Guerra C Piqueras J | 2010 | J Phys D:Appl Phys2010，43，13： | 1 |
| 17 | Iodine status and thyroid volume changes during pregnancy: results of a survey in Aran Valley (Catalan Pyrenees) 显示文摘 | Vila L Legaz G Barrionuevo C etal | 2008 | J Endocrinol Invest2008，31，10： | 1 |
| 18 | Retrospective observational study of the management of multiple sclerosis patients with resistant spasticity in Spain:the '5E' study 显示文摘 | Arroyo R Vila C Clissold S | 2011 | Expert Rev Pharmacoecon Outcomes Res2011，11，2： | 1 |
| 19 | Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease显示文摘 | WU D C JACKSON-LEWIS V VILA M | 2002 | Neurosci2002，22，5： | 1 |
| 20 | Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease显示文摘 | WU D C JACKSON-LEWIS V VILA M | 2002 | J Neurosci2002，22，5： | 1 |
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