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| 1 | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease显示文摘Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment.The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s disease.Alzheimer’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus bilaterally.Morris water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after administration.Afterwards,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM antibodies.Results showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem cells.These findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s disease.All procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval No.CICUAL 2016-011)on April 25,2016. | Edwin E. Reza-Zaldivar Mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-Mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre | 2019 | Neural Regeneration Research2019，14，9： | 19 |
| 2 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 3 | Germanene: a novel two-dimensional germanium allotrope akin to graphene and silicene显示文摘 | M E Dávila L Xian S Cahangirov A Rubio G Le Lay | 2014 | New Journal of Physics2014，，： | 3 |
| 4 | Levels of anti-Inflammatory cytokines and neurological worsening in acute ischemic stroke显示文摘 | Vila N Castillo J Davalos A | 2003 | Stroke2003，34，3： | 1 |
| 5 | Proinflammatory cytokines and ealy neurological worsening in ischemic artoke显示文摘 | Vila N Castilo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 6 | Sevoflurane in airway management using fibrobronchoscopy:apropos of 2 difficult orotracheal intubation cases显示文摘 | FERRA M VILA P ESCUDERO A | 1999 | Rev Esp Anestesiol Reanim1999，46，6： | 1 |
| 7 | Design of biodegradable particles for protein delivery显示文摘 | Vila A Sánchez A Tobio M | 2002 | J Control Release2002，78，： | 1 |
| 8 | Increased glyceraldehyde-3-phosphate dehydrogenase expression in renal cell carcinoma identified by RNA-based,arbitrarily primed polymerase chain reaction显示文摘 | Vila M R Nicolas A Morote J | 2000 | Cancer2000，89，1： | 1 |
| 9 | Antifungal principals from Piper fulvescens显示文摘 | Frexia B Vila R Estenban A | 2001 | Planta Med2001，67，： | 1 |
| 10 | Triamcinolone acetonide mouth rinses for treatment of erosive oral lichen planus :efficacy and risk of ftmgal over - infection显示文摘 | Gonzalez - Garcia A Diniz - Freitas M Gandara - Vila P | 2006 | Oral Dis2006，12，6： | 1 |
| 11 | Shallow gas features in incised valley fills ( Ria de Vigo, NW Spain ) : A case study 显示文摘 | Garcia Gil S Vilas F Garcia Garcia A | 2002 | Continental Shelf Research2002，22，： | 1 |
| 12 | Widespread origins of domestic horse lineages显示文摘 | VILA C LEONARD J A GOTHERSTROM A | 2001 | Science2001，291，5503： | 1 |
| 13 | Proinflammatory cy-tokines and early neurological worsening in ischemicstroke显示文摘 | Vila N Castillo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 14 | Proinflammatorycytokines and early neurological worsening in ischemicstroke显示文摘 | VILA N CASTILLO J DAVALOS A | 2000 | Stroke2000，31，10： | 1 |
| 15 | Levels of anti inflammatory cytokines and neurological worsening in acute ischemic stroke显示文摘 | Vila N Castillo J Divalos A | 2003 | Stroke2003，34，： | 1 |
| 16 | Triflusal Vs Aspirin for Prevention of Cerebral Infarction:A Randomized Stroke Study显示文摘 | Culebras A Rotta-Escalante R Vila J | 2004 | Neurology2004，62，7： | 1 |
| 17 | Proinflammatory cytokines and early neurological worsening in ischemic stroke显示文摘 | Vila N Castillo J Davalos A | 2000 | Stroke2000，31，10： | 1 |
| 18 | Spontaneous transfer of phospholipid and cholesterol hydroperoxides between cell membranes and low-density lipoprotein: assess- ment of reaction kinetics and prooxidant effects 显示文摘 | Vila A Korytowski W Girotti A W | 2002 | Biochemistry2002，41，13： | 1 |
| 19 | Plasma homocysteine levels in patients withischemic cerebral infarction 显示文摘 | VILA N DEULOFEU R CHAMORRO A | 1998 | Med Clin (Barc)1998，110，： | 1 |
| 20 | On aggregation operations of linguistic label显示文摘 | Delgado M Verdegay J L Vila M A | 1993 | International Journal of Intelligent Systems1993，8，： | 1 |
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