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| 1 | Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma:Radiologic-pathologic correlation显示文摘AIM:To identify multi-detector computed tomography(MDCT) features most predictive of serous cystadenomas(SCAs),correlating with histopathology,and to study the impact of cyst size and MDCT technique on reader performance.METHODS:The MDCT scans of 164 patients with surgically verified pancreatic cystic lesions were reviewed by two readers to study the predictive value of various morphological features for establishing a diagnosis of SCAs.Accuracy in lesion characterization and reader conf idence were correlated with lesion size(≤3cm or≥3cm) and scanning protocols(dedicated vs routine).RESULTS:28/164 cysts(mean size,39 mm;range,8-92mm) were diagnosed as SCA on pathology.The MDCT features predictive of diagnosis of SCA were microcystic appearance(22/28,78.6%),surface lobulations(25/28,89.3%) and central scar(9/28,32.4%).Stepwise logistic regression analysis showed that only microcystic appearance was signifi cant for CT diagnosis of SCA(P=0.0001).The sensitivity,specificity and PPV of central scar and of combined microcystic appearance and lobulations were 32.4%/100%/100% and 68%/100%/100%,respectively.The reader confidence was higher for lesions>3cm(P=0.02) and for MDCT scans performed using thin collimation(1.25-2.5mm) compared to routine 5 mm collimation exams(P>0.05).CONCLUSION:Central scar on MDCT is diagnostic of SCA but is seen in only one third of SCAs.Microcystic morphology is the most significant CT feature in diagnosis of SCA.A combination of microcystic appearance and surface lobulations offers accuracy comparable to central scar with higher sensitivity. | Anjuli A Shah Nisha I Sainani Avinash Kambadakone Ramesh Zarine K Shah Vikram Deshpande Peter F Hahn Dushyant V Sahani | 2009 | World Journal of Gastroenterology2009，15，22： | 11 |
| 2 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 3 | Ultrasonic nondestructive evaluation of a three-layered medium显示文摘 | Kinra Vikram K Jaminet Paul Zhu Changyi | 1994 | Materials Evaluation1994，52，： | 1 |
| 4 | Protamine is a low molecular weight polycationic amine that produces actions on cardiac muscle 显示文摘 | Michael K Pugsley Vikram Kalra Sarah Froebel-Wilson | 2002 | Life Sciences2002，72，3： | 1 |
| 5 | Forming of Aluminum Tailor Welded Blanks显示文摘 | Brad K Vikram V Jian C | 2001 | Journal of Materials & Manufacturing2001，10，5： | 1 |
| 6 | The Physics and Technology of Gallium Antimonide: An Emerging Optoelectronic Material显示文摘 | Dutta P S Bhat H L Vikram K | 1997 | J Appl Phys1997，81，： | 1 |
| 7 | Foveal structure defined by spectral domain optical coherencetomography correlates with visual function after macular holesurgeiy显示文摘 | Kakarala V Ravi K Shailesh K Gupta B Vikram S Sandeep G | 2010 | Eur J Ophthalmol2010，20，3： | 1 |
| 8 | Clinical progression of methicillin-resistant Staphylococcus aureus vertebral osteomyelitis associated with reduced susceptibility to daptomycin显示文摘 | Holenarasipur R Vikram N L Havill L K | | 0，，10： | 1 |
| 9 | Clinical and pathophysiological conse- quences of abdominal adiposity and abdominal adipose tissue depots显示文摘 | Misra A Vikram N K | 2003 | Nutrition2003，19，5： | 1 |
| 10 | Psoriasis treatment: Unconventional and non-standard modalities in the era of biologics显示文摘Psoriasis is a potentially debilitating inflammatory dermatosis affecting 0.2%-4.8% of the population worldwide causing a significant occupational, personal or psychosocial morbidity to these patients for life. The basic aim of psoriasis therapy is to control the disease to maximum possible extent and improve the patient's quality of life. Management of triggers for flareups, lifestyle modifications, and dietary supplements are often recommended. Intermittent or rotational therapy with frequent alterations in treatment options is usually needed to reduce toxicity of anti-psoriatic drugs in the absence of safer alternatives. Currently, several biological agents categorized as either T-cell targeted(e.g., Alefacept, Efalizumab) or cytokine modulating(e.g., Adalimumab, Infliximab, Etanercept) are available for treating severe psoriasis. However, their high cost is often precluding for most patients. The usefulness of systemic(methotrexate, cyclosporine, acitretin or several other therapeutic agents) or topical(tar, anthralin, corticosteroids or calcipotriol ointments, phototherapy with or without psoralens) therapies has been well established for the management of psoriasis. The literature is also replete with benefits of less used non-standard and unconventional treatment modalities(hydroxycarbamide, azathioprine, leflunomide, mycophenolate mofetil, isotretinoin, fumarates, topical calcineurin inhibitors, peroxisome proliferator-activated receptors agonists, statins, sulfasalazine, pentoxifylline, colchicine, grenz ray therapy, excimer laser, climatotherapy and balneophototherapy, peritoneal dialysis, tonsillectomy, ichthyotherapy, etc.). These can be used alternatively to treat psoriasis patients who have mild/minimal lesions, are intolerant to conventional drugs, have developed side effects or achieved recommended cumulative dose, where comorbidities pose unusual therapeutic challenges, or may be as intermittent, rotational or combination treatment alternatives. | Vikram K Mahajan | 2016 | World Journal of Dermatology2016，5，1： | 1 |
| 11 | Particle Filters for State Estimation of Jump Markov Linear Systems显示文摘 | Doucet A Gordon N J Vikram K | 2001 | IEEE Trans on Signal Processing2001，49，3： | 1 |
| 12 | Particle filters for state estimation of lump Markov linear systems 显示文摘 | Doucet A Gordon N J Vikram K | 2001 | IEEE Trans on Signal Processing2001，49，3： | 1 |
| 13 | Hardware-software cosimulation of bus-based reconfigurable systems显示文摘 | VIKRAM K N VASUDENVAN V | 2005 | Microprocecessors and Microsystems2005，29，4： | 1 |
| 14 | Role of selected Indian plants in management of type 2 diabetes:a review显示文摘 | Saxena A Vikram N K | 2004 | Journal of Alternative and Complementary Medicine2004，10，2： | 1 |
| 15 | A new mathematical model and control of a three-phase AC-DC voltage source converter 显示文摘 | VLADIMIR B VIKRAM K | 1997 | IEEE Trans on Power Electronics1997，12，1： | 1 |
| 16 | Knightly ensuring latency targets in multiclass web servers显示文摘 | Vikram K Edward W | 2002 | IEEE Transactions on Parallel and Distributed Systems2002，，10： | 1 |
| 17 | Particle filters for state estimation of jump markov linear systems显示文摘 | ARNAUD D NElL J G VIKRAM K | 2001 | IEEE Transactions on Signal Processing2001，49，3： | 1 |
| 18 | Robust stabilization for systems with parametric uncertainty and time delay 显示文摘 | Vikram K Wassim M H | 1999 | J of the Franklin Institute1999，336，： | 1 |
| 19 | Seml: a versatile ' molecular glue'? 显示文摘 | Marius B F Stefan K Vikram G P | 2010 | Nucleus2010，1，1： | 1 |
| 20 | Clinical and patho- physiological consequences of abdominal adiposity and abdominal adipose tissue depots 显示文摘 | Misra Anoop Vikram Naval K | 2003 | Nutrition2003，19，5： | 1 |
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