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| 1 | Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process显示文摘Aging is a dynamic and progressive process that begins at conception and continues until death.This process leads to a decrease in homeostasis and morphological,biochemical and psychological changes,increasing the individual’s vulnerability to various diseases.The growth in the number of aging populations has increased the prevalence of chronic degenerative diseases,impairment of the central nervous system and dementias,such as Alzheimer’s disease,whose main risk factor is age,leading to an increase of the number of individuals who need daily support for life activities.Some theories about aging suggest it is caused by an increase of cellular senescence and reactive oxygen species,which leads to inflammation,oxidation,cell membrane damage and consequently neuronal death.Also,mitochondrial mutations,which are generated throughout the aging process,can lead to changes in energy production,deficiencies in electron transport and apoptosis induction that can result in decreased function.Additionally,increasing cellular senescence and the release of proinflammatory cytokines can cause irreversible damage to neuronal cells.Recent reports point to the importance of changing lifestyle by increasing physical exercise,improving nutrition and environmental enrichment to activate neuroprotective defense mechanisms.Therefore,this review aims to address the latest information about the different mechanisms related to neuroplasticity and neuronal death and to provide strategies that can improve neuroprotection and decrease the neurodegeneration caused by aging and environmental stressors. | Mariana Toricelli Arthur Antonio Ruiz Pereira Guilherme Souza Abrao Helena Nascimento Malerba Julia Maia Hudson Sousa Buck Tania Araujo Viel | 2021 | Neural Regeneration Research2021，16，1： | 8 |
| 2 | Acute Severe Isovolemic Anemia Impairs Cognitive Function and Memory in Humans显示文摘 | Richard B. Weiskopf Joel H. Kramer Maurene Viele Mireille Neumann John R. Feiner Jessica J. Watson Harriet W. Hopf Pearl Toy | 2000 | Anesthesiology2000，，6： | 2 |
| 3 | Interendoscopist variability in proximal colon polyp detection is twice higher for serrated polyps than adenomas显示文摘AIM To assess the interendoscopist variability in the detection of colorectal polyps according to their location and histological type.METHODS This study was a retrospective analysis of prospectively collected data from a regional colorectal cancer(CRC) screening program; 2979 complete colonoscopies from 18 endoscopists were included. Variability in performance between endoscopists for detection of at least one adenoma(A), one proximal adenoma(PA), one distal adenoma(DA), and one proximal serrated polyp(PSP) was assessed by using multilevel logistic regression models.RESULTS The observed detection rates among the 18 endoscopists ranged from 24.6% to 47.6%(mean = 35.7%) for A, from 19.1% to 39.0%(mean = 29.4%) for DA, from 6.0% to 22.9%(mean = 12.4%) for PA, and from 1.3% to 19.3%(mean = 6.9%) for PSP.After adjusting for patient-level variables(sex, age), the interendoscopist detection rates variability achieved a significant level for A, PA, and PSP but not for DA(P = 0.03, P = 0.02, P = 0.02 and P = 0.08, respectively). This heterogeneity, as measured by the variance partition coefficient, was approximately threefold higher for PA(6.6%) compared with A(2.1%), and twofold higher for PSP(12.3%) compared with PA.CONCLUSION These results demonstrate significant interendoscopist variability for proximal polyp particularly for serrated p o l y p s, b u t n o t f o r d i s t a l a d e n o m a d e t e c t i o n. These findings contribute to explain the decreased effectiveness of complete colonoscopies at preventing proximal CRCs and the need to carefully assess the proximal colon during scope procedure. | Jean-François Bretagne Stéphanie Hamonic Christine Piette Jean-François Viel Guillaume Bouguen | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 4 | Nutrient profiles in the pore water of a deltaic lagoon: Methodological considerations and evaluation of benthic fluxes 显示文摘 | Viel M Barbanti A Langone L Buffoni G Paltfinieri D Rosso G | 1991 | Estuar Coastal Shelf Sci1991，33，4： | 1 |
| 5 | Could a defectiveepithelial sodium channel lead to bronchiectasis 显示文摘 | Fajac I Viel M Sublemontier S | 2008 | RespirRes2008，9，： | 1 |
| 6 | Garlic, onion and cereal fibre as protective factors for breast cancer: French case-control study显示文摘 | Challier B Perarnau JM Viel JF | 1998 | Eur J Epidemiol1998，14，： | 1 |
| 7 | Clinical application of ropivacaine for lower extremity显示文摘 | Eledjam JJ Ripart J Viel E | 2001 | Curr Top Med Chem2001，1，3： | 1 |
| 8 | Evaluation of the antiurolithiatic activity of the extract of Costus spiralis Roscoe in rats 显示文摘 | Viel T A Domingos C D Monteiro A P S | 1999 | J Ethnopharnuwol1999，66，2： | 1 |
| 9 | Brain cancer mortality among French farmers:the vineyard pesticide hypothesis 显示文摘 | Viel J F ChaUier B Pitard A | 1998 | Environment Health1998，53，1： | 1 |
| 10 | IL-2 and TNFA gene polymorphisms and the risk of graft-versus-host disease after allogeneic haematopoietic stem cell transplantation显示文摘 | Viel DO Tsuneto LT Sossai CR | 2007 | Scand J Immunol2007，66，6： | 1 |
| 11 | Acute severeisovolemic anemia impairs cognitive function and memoryin humans显示文摘 | Weiskopf RB Kramer JH Viele M | 2000 | Anesthesiology2000，92，： | 1 |
| 12 | Suppressive role of the metastasis related nm23-H1 gene in humam ovarian cancer:association of high messenger RNA expression with lack of lymph node metastasis显示文摘 | Viel A Agnese LD canzonieri V | 1995 | Cancer Res1995，55，12： | 1 |
| 13 | A stable control structure for binary distillation columns显示文摘 | VIEL F BUSVELLE E GAUTHIER J P | 1997 | Int J Control1997，67，4： | 1 |
| 14 | managing oral chemotherapy:the health care practi- tioners role显示文摘 | viele cs | 2007 | Am J Health-syst pharm2007，64，9： | 1 |
| 15 | Immune regulation and vascular inflammation in genetic hypertension显示文摘 | Viel EC Lemarie CA Benkirane K | 2010 | Art l Phys- iol Heart Circ Physiol2010，298，3： | 1 |
| 16 | Immune regulation and vascular inflammation in genetic hypertension显示文摘 | Viel EC Lcmari6 CA Benkirane K | 2010 | Am J Phys- iol Heart Circ Physiol2010，298，3： | 1 |
| 17 | Improved solid-state NMR quantiflcations of active principles in pharmaceutical formulations 显示文摘 | Sanchez S Ziarelli F Viel S | 2008 | J Pharm Biomed Anal2008，47，45： | 1 |
| 18 | Brachial plexus block with o-pioids for posroperative pain relief:Comparison between buprenor phine and morphine显示文摘 | Viel EJ Eledjam JJ Coussage D | 1990 | Reg Anesth1990，12，： | 1 |
| 19 | Oxygen Reverses Deficits of Cognitive Function and Memory and Increased Heart Rate Induced by Acute Severe Isovolemic Anemia显示文摘 | Richard B. Weiskopf John Feiner Harriet W. Hopf Maurene K. Viele Jessica J. Watson Joel H. Kramer Rachel Ho Pearl Toy | 2002 | Anesthesiology2002，，4： | 1 |
| 20 | Raman micro- scopic investigation of paint samples from theRosali- la building, Copan, Honduras 显示文摘 | Goodall R A Hall J Viel R | 2006 | J Raman Spec- trosc2006，37，10： | 1 |
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