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| 1 | Pathogenic mechanisms of pancreatitis显示文摘Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute inflammatory responses and; chronic pan-creatitis characterized by marked stroma formation with a high number of infiltrating granulocytes(such as neutrophils, eosinophils), monocytes, macrophages and pancreatic stellate cells(PSCs). These inflammatory cells are known to play a central role in initiating and promoting inflammation including pancreatic fibrosis, i.e., a major risk factor for pancreatic cancer. A number of inflammatory cytokines are known to involve in pro-moting pancreatic pathogenesis that lead pancreatic fibrosis. Pancreatic fibrosis is a dynamic phenomenon that requires an intricate network of several autocrine and paracrine signaling pathways. In this review, we have provided the details of various cytokines and molecular mechanistic pathways(i.e., Transforming growth factor-β/SMAD, mitogen--activated protein kinases, Rho kinase, Janus kinase/signal transducers and activators, and phosphatidylinositol 3 kinase) that have a critical role in the activation of PSCs to promote chronic pancreatitis and trigger the phenomenon of pancreatic fibrogenesis. In this review of literature, we discuss the involvement of several pro-inflammatory and anti-inflammatory cytokines, such as in interleukin(IL)-1, IL-1β, IL-6, IL--8 IL-10, IL-18, IL--33 and tumor necrosis factor-α, in the pathogenesis of disease. Our review also highlights the significance of several experimental animal models that have an important role in dissecting the mechanistic pathways operating in the development of chronic pancreatitis, including pancreatic fibrosis. Additionally, we provided several intermediary molecules that are involved in major signaling pathways that might provide target molecules for future therapeutic treatment strategies for pancreatic pathogenesis. | Murli Manohar Alok Kumar Verma Sathisha Upparahalli Venkateshaiah Nathan L Sanders Anil Mishra | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 21 |
| 2 | Diffraction of elastic P waves by two equal co-axial circular rigid strips显示文摘 | Verma S K Jain D L | 1992 | European Journal of Mechanics A/Solids1992，11，2： | 2 |
| 3 | 14 Years of Eosinophilic Esophagitis: Clinical Features and Prognosis显示文摘 | Jonathan M Spergel Terri F Brown-Whitehorn Janet L Beausoleil James Franciosi Michele Shuker Ritu Verma Chris A Liacouras | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，1： | 2 |
| 4 | Changes in round bales during storge 显示文摘 | Verma L Nelson B D | 1983 | Trans ASAE1983，26，： | 1 |
| 5 | insulin resistance as a therapeutic target for improved endothelial function: metformin 显示文摘 | Brame L Verma S Anderson T | 2004 | Curt Drug Targets Cardiovasc Haematol Disord2004，4，1： | 1 |
| 6 | Signal-dependent and independent degradation of free and NF-Kappa B-bound IkappaBalpha显示文摘 | Pando M P Verma L M | 2000 | J Biol Chem2000，275，21： | 1 |
| 7 | Detecting subarach noid hemorrhage: comparison of combined FLAIR/SWI versus CT显示文摘 | Verma RK Kottke R Andereggen L | 2013 | Eur J Radiol2013，82，9： | 1 |
| 8 | Synthesis of PEDOT:PSS(poly(3,4-ethylenedioxythiophene/poly(4-styrene sulfonate/ngps(nanographitic platelets) nanocomposites as chemiresistive sensors for detection of nitroaromatics显示文摘 | Rattan S Singhal P Verma A L | | 0，，10： | 1 |
| 9 | Expression and cellular localization of the Mas receptor in the adult and developing mouse retina 显示文摘 | Tuhina Prasad Amrisha Verma Qiuhong L | 2014 | Mol Vis2014，20，： | 1 |
| 10 | An improved process for the purification of phosphogypsum 显示文摘 | SINGH M GARG M VERMA C L | 1996 | Construct Build Mater1996，10，： | 1 |
| 11 | Feeder bus routes generation within integrated mass transit planning framework显示文摘 | Verma A Dhingr a S L | 2005 | Journal of Transportation Engineering2005，131，11： | 1 |
| 12 | Degradation of predi- gested distillery effluent by isolated bacterial strains显示文摘 | JAIN N MINOCHA A K VERMA C L | 2002 | Indian Journal of Experimental Biology2002，40，1： | 1 |
| 13 | Effect of inorganic materials on the solidification of heavy metal sludge显示文摘 | Jain N Minocha A K Verma C L | 2003 | Cement Concrete Research2003，33，： | 1 |
| 14 | An improved process for the purification of phosphogypsum显示文摘 | Manjit Singh Mridul Garg C L Verma | 1996 | construction and building materials1996，10，8： | 1 |
| 15 | TiO2 thin films prepared via adsorptive self-assembly for self-cleaning applications显示文摘 | Xi B J Verma L K Li J | 2012 | Applied Materials & Interfaces2012，，4： | 1 |
| 16 | Trastuzumab emtansine (TDM-1) for Her2-positive advanced breast cancer显示文摘 | Verma S Miles D Gianni L | 2012 | N Engl J Med2012，367，19： | 1 |
| 17 | On the propagation of waves in layered anisotropic media in generalized thermoelasticity显示文摘 | Verma K L | 2002 | International Journal of Engineering Science2002，40，20： | 1 |
| 18 | Developing integrated schedules for urban rail and feeder bus operation显示文摘 | Verma A Dhingra S L | | 0，，03： | 1 |
| 19 | Substrate and Trigger Ablation for Reduction of Atrial Fibrillation (STAR AF):a randomized,multicentre,international trial显示文摘 | Verma A Mantovan R Macle L | | 0，，11： | 1 |
| 20 | Seismic Analysis and Design with Maxwell Dampers 显示文摘 | SINGH M P VERMA N P MORESCHI L M | 2003 | Journal of Engineering Mechanics2003，129，3： | 1 |
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