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| 1 | Cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer显示文摘Breast cancer is the leading cause of death among women worldwide.Chemoprevention and chemotherapy play beneficial roles in reducing the incidence and mortality of cancer.Epidemiological and experimental studies showed that naturally-occurring antioxidants present in the diet may act as anticancer agents.Identifying the abnormalities of cellular energy metabolism facilitates early detection and management of breast cancer.The present study evaluated the effect of tangeretin on cellular metabolic energy fluxes in 7,12-dimethylbenz(a)anthracene(DMBA)-induced proliferative breast cancer.The results showed that the activities of glycolytic enzymes significantly increased in mammary tissues of DMBA-induced breast cancer bearing rats.The gluconeogenic tricarboxylic acid(TCA) cycle and respiratory chain enzyme activities significantly decreased in breast cancer-bearing rats.In addition,proliferating cell nuclear antigen(PCNA) was highly expressed in breast cancer tissues.However,the activities of glycolytic enzymes were significantly normalized in the tangeretin pre- and post-treated rats and the TCA cycle and respiratory chain enzyme activities were significantly increased in tangeretin treated rats.Furthermore,tangeretin down-regulated PCNA expression on breast cancerbearing rats.Our study demonstrates that tangeretin specifically regulates cellular metabolic energy fluxes in DMBA-induced breast cancer-bearing rats. | Kuppusamy Periyasamy Venkatachalam Sivabalan Kuppusamy Baskaran Kannayiram Kasthuri Dhanapal Sakthisekaran | 2016 | The Journal of Biomedical Research2016，30，2： | 3 |
| 2 | 铬解毒机制诱导香根草的生长和抗氧化反应(英文)显示文摘本文研究了铬(Cr)对香根草(Chrysopogon zizanioides)生长以及抗氧化防御酶活性的影响,探讨其对Cr的解毒机制。在50 mg/L Cr处理条件下,植物地上部分和地下部分的生长量分别降低了36.8%和45.0%;Cr在植物地下部分的积累量(9807μg/g干重)大于地上部分的积累量(8730μg/g干重)。随着Cr添加量的增加,光合色素和丙二醛含量增加,在30 mg/L Cr处理条件下含量达到最高,之后,随着Cr处理浓度的增加略有下降;同时,抗氧化防御酶(超氧化物歧化酶、过氧化氢酶和过氧化物酶)的活性显著提高,在较高浓度Cr处理下略有下降。同工酶结果显示在高浓度Cr处理下,超氧化物歧化酶、过氧化氢酶和过氧化物酶的条带强度降低。目前研究结果表明,高浓度Cr导致活性氧过量产生,从而增加了对香根草的氧化损伤,而光合色素、丙二醛、抗氧化酶含量的增加表明香根草对Cr有潜在的耐性机制。结果表明,香根草具有对Cr的解毒机制,并可以积累高浓度的Cr。本文为更深入地研究根草对Cr的解毒机制提供了依据。 | Manikdanan RAJENDRAN 安文慧 李伟展 Venkatachalam PERUMAL 吴川 Shivendra Vikram SAHI Santosh Kumar SARKAR | 2019 | Journal of Central South University2019，26，2： | 3 |
| 3 | The contingent valuation method: a review显示文摘 | L. Venkatachalam | 2003 | Environmental Impact Assessment Review2003，，1： | 2 |
| 4 | Al-MCM-48分子筛对苯酚与乙酸异丙酯异丙基化反应的催化性能(英文)显示文摘Al-MCM-48 molecular sieves (Si/Al molar ratios = 25, 50, 75, and 100) were synthesized hydrothermally using cetyltrimethyl-ammonium bromide as the structure directing template. The orderly arrangement of mesopores was evident from the low angle X-ray diffraction patterns and transmission electron microscopy images. The catalytic performance of the materials was evaluated in the vapor phase isopropylation of phenol with isopropyl acetate. Phenol conversion decreased with the increase in the Si/Al ratio of the catalysts. The major reaction product was 4-isopropyl phenol with 78% selectivity. The delocalization of phenolic oxygen electron pair over the aromatic ring promoted para-selective alkylation. Such delocalization could be aided by the hydrophilic surface of the molecular sieves. Although an ester was used as the alkylating agent, phenyl isopropyl ether was not formed in the reaction. | Kandan VENKATACHALAM Pitchai VISUVAMITHIRAN Balachandran SUNDARAVEL Muthiapillai PALANICHAMY Velayutham MURUGESAN | 2012 | 催化学报2012，33，3： | 2 |
| 5 | Identification of lead-regulated genes by suppression subtractive hybridization in the heavy metal accumulator Sesbania drummondii显示文摘 | Srivastava A K Venkatachalam P Raghothama K G | 2007 | Planta2007，225，6： | 1 |
| 6 | Inhibition of Mast Cell Leukotriene Release by Thiourea Derivatives显示文摘 | Venkatachalam T K Qazi S Samuel P | 2003 | Bioorg Med Chem Lett2003，13，： | 1 |
| 7 | Sol-gel preparation and characterization of nanosize TiO2:Its photocatalytic performance显示文摘 | Venkatachalam N Palanichamy M Murugesan V | 2007 | Materials Chemistry and Physics2007，104，23： | 1 |
| 8 | Sueeessful abla- tion of atrial tachycardia in the right coronary cusp of the aortic valve in a patient with atrial fibrillation : what is the substrate 显示文摘 | Gami AS Venkatachalam KL Friedman PA | 2008 | J Card- iovasc Electrophysio12008，19，： | 1 |
| 9 | Long-cycle electrochemical behavior of multiwall carbon nanotubes synthesized on stainless steel in Li ion batteries显示文摘 | Charan Masarapu Venkatachalam Subramanian Zhu Hongwei | | 0，，07： | 1 |
| 10 | A Direct Comparison of Early and Late Outcomes With Three Approaches to Carotid Revascularization and Open Heart Surgery显示文摘 | Shishehbor MH Venkatachalam S Sun Z | 2013 | J Am Coil Cardio12013，62，21： | 1 |
| 11 | Sol-gel preparation and characterization of nanosize Ti O2:its photocatalytic performance显示文摘 | Venkatachalam N Palanichamy M Murugesan V | 2007 | Materials Chemistry and Physics2007，104，2： | 1 |
| 12 | 不同官能团的蒽醌结构调控及其对锂离子电池材料电化学性能的影响(英文)显示文摘有机电极材料作为下一代锂离子电池材料具有容量高,环境友好型等优势。然而,有机电极材料面临着许多挑战,如作为正极材料的放电平台低,而作为负极材料的放电平台高。本文研究了具有供电子和吸电子效应的化学官能团对蒽醌(AQ)体系的还原电位和充放电性能的影响。循环伏安法结果表明,在蒽醌结构上引入两个—OH基团、两个—NO2基团和一个—CH3基团对蒽醌结构的还原电位影响较小,还原电位为2.1 V。但在AQ结构上引入3~4个—OH基团时,还原电位增加到~3.1 V。充放电测试表明这些材料具有适中的循环稳定性。 | 钱素惠 潘俊贤 朱肇昇 叶锐添 林耿忠 朱潇行 熊志勇 GANESH Venkatachalam 曾荣华 罗一帆 | 2019 | Journal of Central South University2019，26，6： | 1 |
| 13 | Reliability analysis of slopes using fuzzy sets theory显示文摘 | Venkatachalam G | 2000 | Computers and Geotechics2000，27，2： | 1 |
| 14 | Analysis of radiation dose-response curve obtained with cytokinesis block micronucleus assay显示文摘 | Paul SF Venkatachalam P Jeevanram RK | 1997 | Nucl Med Biol1997，24，5： | 1 |
| 15 | Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C显示文摘 | Venkatachalam K Zheng F Gill DL | 2003 | J Biol Chem2003，278，29： | 1 |
| 16 | Genes induced in response to mercury-ion-exposure in heavy metal hyperaccumulator Sesbania drummondi显示文摘 | Venkatachalam P Srivastava A Raghothama K | 2009 | Environ Sci Technol2009，43，3： | 1 |
| 17 | Development of a new steering mechanism for automobiles 显示文摘 | VENKATACHALAM R PADMA R A | 2012 | Advances in Reconfigurable Mechanisms and Robots2012，2012，： | 1 |
| 18 | Reductive dechlorination of 3, 3 ', 4, 4 '-tatrachlorobiphenyl (PCB77) using palladium or palladium/iron nanoparticles and assessment of the reduction in toxic potency in vascular endothelial cells 显示文摘 | VENKATACHALAM K ARZUAGA X CHOPRA N | 2008 | Journal of Hazardous Materials2008，159，： | 1 |
| 19 | Pulsed electrogeneration of bubbles for electroflotation显示文摘 | KHOSLA N K VENKATACHALAM S | 1991 | Journal of Applied Electrochemistry1991，21，： | 1 |
| 20 | The contingent valuation method:a review显示文摘 | Venkatachalam L | 2004 | Environmental Impact Assessment Review2004，24，： | 1 |
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