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| 1 | Growth mechanism of octahedron-like BaMoO_4 microcrystals processed in microwave-hydrothermal:Experimental observations and computational modeling显示文摘Octahedron-like BaMoO4 microcrystals were synthesized by the co-precipitation method at room temperature and processed in microwave-hydrothermal at 413 K for different times (from 30 min to 5 h). These microcrystals were analyzed by X-ray diffraction (XRD),field-emission gun scanning electron microscopy (FEG-SEM) and transmission electron microscopy (TEM). XRD patterns showed that this material presents a tetragonal structure without the presence of deleterious phases. FEG-SEM and TEM micrographs revealed that the BaMoO4 microcrystals present an octahedron-like morphology with agglomerate nature and poly-disperse particle size distribution. These micrographs also indicated that the microcrystals grow along the [0 0 1] direction. The observed crystallographic planes in these structures were modeled computationally and a crystal growth model was proposed in order to explain the morphological changes as a function of processing time. | Laécio Santos Cavalcante Júlio César Sczancoski Rircado Luis Tranquilin José Arana Varela Elson Longo Marcelo Ornaghi Orlandi | 2009 | Particuology2009，7，5： | 9 |
| 2 | Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study显示文摘瞄准:与前列腺癌症的调节的人冒的风险的一个环境因素在联合估计几个基因因素的角色。我们集中于与房间控制联系的低外显率的基因的等位基因变体, detoxification 进程并且吸烟。方法:在盒子控制研究,我们比较了与他们的前列腺癌症风险带 p53cd72 职业人员等位基因, CYP1A1 M1 等位基因和 GSTM1 空遗传型的人。结果:为带专业版的吸烟者的联合风险 * 并且 M1 * ,专业版 * 并且 GSTM1null 或 GSTM1 0 和 CYP1A1 M1 * 变体显著地更高(机会比率[或] :13.13, 95% 信心间隔[CI ] :2.41-71.36;或:3.97, 95% CI:1.13-13.95 并且或:6.87, 95% CI:1.68-27.97,分别地) 不为参考组,并且为不抽烟的人与那相比是重要的。或为在 p53cd72, GSTM1 和 CYP1A1 之中的联合,在吸烟者的 M1 断然并且显著地与不抽烟的人相比并且与通常认为的最低风险组相比与前列腺癌症风险被联系(或:8.87, 95% CI:1.25-62.71 ) 。结论:我们的结果建议那在修改前列腺癌症的一个重要角色在学习人口上冒的风险的 p53cd72, CYP1A1, GSTM1 等位基因和吸烟的戏的联合,哪个带易受影响的遗传型的吸烟者可能有的工具显著地更高的风险比带非易受影响的遗传型的那些。 | Luis A. Quinones Carlos E. Irarrázabal Claudio R. Rojas Cristian E. Orellana Cristian Acevedo Christian Huidobro Nelson E. Varela Dante D. Cáiceres | 2006 | Asian Journal of Andrology2006，8，3： | 6 |
| 3 | Sirtuin 1 in rat orthotopic liver transplantation:An I GL-1 preservation solution approach显示文摘AIM:To investigate the possible involvement of Sirtuin1(SIRT1)in rat orthotopic liver transplantation(OLT),when Institute Georges Lopez 1(IGL-1)preservation solution is enriched with trimetazidine(TMZ).METHODS:Male Sprague-Dawley rats were used as donors and recipients.Livers were stored in IGL-1 preservation solution for 8h at 4℃,and then underwent OLT according to Kamada’s cuff technique without arterialization.In another group,livers were stored in IGL-1 preservation solution supplemented with TMZ,at10-6 mol/L,for 8 h at 4℃and then underwent OLT.Rats were sacrificed 24 h after reperfusion,and liver and plasma samples were collected.Liver injury(transaminase levels),mitochondrial damage(glutamate dehydrogenase activity)oxidative stress(malondialdehyde levels),and nicotinamide adenine dinucleotide(NAD+),the cofactor necessary for SIRT1 activity,were determined by biochemical methods.SIRT1 and its substrates(acFox O1,ac-p53),the precursor of NAD+,nicotinamide phosphoribosyltransferase(NAMPT),as well as the phosphorylation of adenosine monophosphate activated protein kinase(AMPK),p-m TOR,p-p70S6K(direct substrate of m TOR),autophagy parameters(beclin-1,LC3B)and MAP kinases(p-p38 and p-ERK)were determined by Western blot.RESULTS:Liver grafts preserved in IGL-1 solution enriched with TMZ presented reduced liver injury and mitochondrial damage compared with those preservedin IGL-1 solution alone.In addition,livers preserved in IGL-1+TMZ presented reduced levels of oxidative stress.This was consistent with enhanced SIRT1 protein expression and elevated SIRT1 activity,as indicated by decreased acetylation of p53 and Fox O1.The elevated SIRT1 activity in presence of TMZ can be attributed to the enhanced NAMPT protein and NAD+/NADH levels.Up-regulation of SIRT1 was consistent with activation of AMPK and inhibition of phosphorylation of m TOR and its direct substrate(p-p70S6K).As a consequence,autophagy mediators(beclin-1 and LC3B)were overexpressed.Furthermore,MAP kinases were regulated in livers preserved with IGL-1+TMZ,as they were characterized by enhanced p-ERK and decreased p-p38protein expression.CONCLUSION:Our study shows that IGL-1 preservation solution enriched with TMZ protects liver grafts from the IRI associated with OLT,through SIRT1 up-regulation. | Eirini Pantazi Mohamed Amine Zaouali Mohamed Bejaoui Emma Folch-Puy Hassen Ben Abdennebi Ana Teresa Varela Anabela Pinto Rolo Carlos Marques Palmeira Joan Roselló-Catafau | 2015 | World Journal of Gastroenterology2015，21，6： | 5 |
| 4 | Computational studies on the seismic response of the State Route 99 bridge in Seattle with SMA/ECC plastic hinges显示文摘This paper reports a computational study on the seismic response of a three-span highway bridge system incorporating conventional and novel substructure details for improved seismic performance.The bridge has three continuous spans supported by two single-column piers and integral abutments founded on drilled shafts.It will be the first full-scale highway bridge to use superelastic shape memory alloy bars (SMA)and engineered cementitious composite (ECC)to mitigate column plastic hinge damage and minimize residual displacements after a strong earthquake. A three-dimensional computational model capturing the nonlinear constitutive response of the novel materials and the effects of dynamic soil-structure interaction was developed to assess the seismic response of the bridge in finite-element software OpenSees.Two versions of the same bridge were analyzed and compared,one with conventional cast-in-place reinforced concrete columns,and the other with top plastic hinges incorporating Nickel-Titanium (NiTi)SMA reinforcing bars and ECC.The novel SMA/ECC plastic hinges were found to substantially reduce damage and post-earthquake residual displacements in the bridge substructure,but led to larger maximum drifts relative to the bridge with conventional reinforced concrete plastic hinges.The analysis results suggested that the novel plastic hinges could lead to improved post-earthquake serviceability of bridges after intense earthquakes. | Jiping GE M.Saiid SAIIDI Sebastian VARELA | 2019 | Frontiers of Structural and Civil Engineering2019，13，1： | 3 |
| 5 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 6 | Colonisation by F aecalibacterium prausnitzii and maintenance of clinical remission in patients with ulcerative colitis显示文摘 | E. Varela C. Manichanh M. Gallart A. Torrejón N. Borruel F. Casellas F. Guarner M. Antolin | 2013 | Aliment Pharmacol Ther2013，，2： | 3 |
| 7 | Variable change in renal function by hypertonic saline显示文摘AIM: To investigate the effects of hypertonic saline in the neurocritical care population.METHODS: We retrospectively reviewed our hospital's use of hypertonic saline(HS) since March of 2005, and prospectively since October 2010. Comparisons were made between admission diagnoses, creatinine change(Cr), and HS formulation(3% Na Cl, 3% Na Cl/sodium acetate mix, and 23.4% Na Cl) to patients receiving normal saline or lactated ringers. The patients(n = 1329) of the retrospective portion were identified. The data presented represents the first 230 patients with data. RESULTS: Significant differences in Acute Physiology and Chronic Health Evaluation Ⅱ scores and GlasgowComa Scale scores occurred between different saline formulations. No significant correlation of Cl- or Na+ with Cr, nor with saline types, occurred. When dichotomized by diagnosis, significant correlations appear. Traumatic brain injury(TBI) patients demonstrated moderate correlation between Na+ and Cr of 0.45. Stroke patients demonstrated weak correlations between Na+ and Cr, and Cl- and Cr(0.19 for both). Patients receiving HS and not diagnosed with intracerebral hemorrhage, stroke, subarachnoid hemorrhage, or TBI demonstrated a weak but significant correlation between Cl- and Cr at 0.29.CONCLUSION: Cr directly correlates with Na+ or Cl- in stroke, Na+ in TBI, and Cl- in other populations. Prospective comparison of HS and renal function is needed. | Jesse J Corry Panayiotis Varelas Tamer Abdelhak Stacey Morris Marlisa Hawley Allison Hawkins Michelle Jankowski | 2014 | World Journal of Critical Care Medicine2014，3，2： | 3 |
| 8 | Cytokine gene polymorphisms and graft-versus-host disease in children after matched sibling hematopoietic stem cell transplantation:a single-center experience显示文摘Various polymorphisms in cytokine genes have recently been investigated as candidate risk factors in allogeneic hematopoetic stem cell transplantation(allo-HSCT).We retrospectively analyzed specific polymorphisms in genes for interleukin(IL)-10,IL-6,tumor-necrosis factor alpha(TNF-α)and interferon gamma(IFN-c)in a pediatric cohort of 57 histocompatibility leucocyte antigen(HLA)-identical sibling myeloablative transplants.Both recipient and donor genotypes were tested for association with graft-versus-host disease(GVHD)by statistical methods including Cox regression analysis.We found a significant association between the IL-10 promoter haplotype polymorphisms at positions-1082,-819 and-592 with the occurrence of severe(grades Ⅲ–Ⅳ)acute GVHD(aGVHD).Recipients with the haplotype GCC had a statistically significant decreased risk of severe aGVHD(hazard risk(HR)50.20,95% confidence interval(CI):0.06–0.67)in comparison with patients with other IL-10 haplotypes(P50.008).Transplant-related mortality at 1 year was significantly lower in recipients with this haplotype(HR50.17,95% CI:0.012–0.320)versus other IL-10 haplotypes(P=0.03),whereas overall survival was not influenced by IL-10 haplotype polymorphisms.In multivariate analysis,the presence of the IL-10 GCC haplotype was found as the only variable associated with a statistically significant decreased hazard of severe aGVHD development(P=0.02,HR50.21,95% CI:0.05–0.78).These results suggest that pediatric patients possessing the IL-10 GCC haplotype may be protected from the occurrence of severe aGVHD in the setting of matched sibling HSCT. | Evgenios Goussetis Ioanna Varela Ioulia Peristeri Vasiliki Kitra Kleopatra Spanou Olga Moraloglou Anna Paisiou Sofia Karatasaki Alexandra Soldatou Nikki Constantinidou Stelios Graphakos | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 9 | Connective tissue growth factor (CTGF) expression in rat corneas after photorefractive keratectomy and stimulation by transforming growth factor beta (TGF-β)显示文摘 | Blalock TD Varela JC Goldstein MH | 2001 | Invest Ophthalmol Vis Sci2001，，： | 2 |
| 10 | 成人脑死亡判定的循证医学指南更新--美国神经病学会质量标准分会报告显示文摘目的就如下问题对美国神经病学会1995年脑死亡判定实践标准进行更新:①符合脑死亡临床判定标准的患者神经功能能恢复吗?②确定患者神经功能永久性停止的恰当观察时间是多长?③有时可能观察到脑死亡患者的复合肢体运动,这是否错误地提示仍然保留脑功能?④何种技术手段判断呼吸停止是相对安全的?⑤是否存在新的辅助检测能准确判断患者脑死亡?方法系统回顾MEDLINE及EMBASE数据库1996年1月—2009年5月收录的文献,其研究仅限于成年人(≥18岁)。结果及建议对成年人,按照美国神经病学会于1995年确定的脑死亡判定实践标准,目前尚无判定为脑死亡患者出现神经功能恢复的报告。脑死亡患者可以存在复合的自发运动及假阳性触发呼吸机。目前还无足够的证据用以确定神经功能不可逆性停止的最短观察时间。通过氧扩散来确定呼吸停止是安全的,但目前还无足够证据确定呼吸停止检测技术的相对安全性。目前还无足够的证据确定新型辅助检测能否准确判断患者全脑功能已经停止。 | Wijdicks EFM Varelas PN Gronseth GS Greer DM 王宁(译) 何福亮(译) | 2010 | 中国脑血管病杂志2010，7，9： | 2 |
| 11 | Antiferroelectricity in multi- ferroic BiCrO3 epitaxial films 显示文摘 | Kim D H Lee H N Varela M | 2006 | Appl Phys Lett2006，89，16： | 1 |
| 12 | Videothoracoscopic extrapleural insertion of Walter Lorenz Surgical bar for pectus excavatum 显示文摘 | Hernandez H Varela A Cordoba M | 2003 | J Thorac Cardiovasc Surg2003，126，6： | 1 |
| 13 | Protein coding assignment of avian reovirus strain S1133 显示文摘 | Varela R Benavente J | 1994 | Journal of Virology1994，68，： | 1 |
| 14 | Color-opponent responses in the avian lateral geniculate: a study in the quail(Coturnix coturnix japonica) 显示文摘 | Maturana H R Varela F J | 1982 | Brain Res1982，247，： | 1 |
| 15 | Protein architecture of avian reovirus S1133 and identification of the cell attachment protein显示文摘 | Martinez C J Grande A Varela R | 1997 | J Virol1997，71，： | 1 |
| 16 | Early lung allograft function after retrograde and antegrade preservation显示文摘 | Varela A Cordoba M Serrano-Fiz S | 1997 | J Thorac Cardiovasc Surg1997，114，： | 1 |
| 17 | Effects of Microwave Heating on Sensory Characteristics of Kiwifruit Puree显示文摘 | María Benlloch-Tinoco Paula Varela Ana Salvador Nuria Martínez-Navarrete | 2012 | Food and Bioprocess Technology2012，，8： | 1 |
| 18 | Radical embodiment: neural dynamics and consciousness显示文摘 | Evan Thompson Francisco J · Varela | 2001 | Trends in Cognition Science52001，，10： | 1 |
| 19 | Chemoembolization of hepatocellular carcinoma with drug eluting beads:efficacy and doxorubicin pharmacokinetics显示文摘 | Varela M Real MI Burrel M | 2007 | J Hepatol2007，46，3： | 1 |
| 20 | Chronic AT(1) blockade stimulates extracellular collagen type I degradation and reverses myocardial fibrosis in spontaneously hypertensive rats显示文摘 | Varo N Iraburu MJ Varela M | 2000 | Hypertension2000，35，6： | 1 |
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