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| 1 | 大熊猫取食竹笋期间的昼夜活动节律和强度显示文摘采用内置记录活动水平传感器的GPS项圈研究了卧龙自然保护区3只野生大熊猫春季取食竹笋期间的昼夜活动节律和强度,并分析了太阳辐射、温度因子对大熊猫活动节律与强度的影响。3只大熊猫的平均活动率为68.05%,受孕雌性大熊猫的活动率(70.86%)和活动强度(范围:0—255;水平方向/垂直方向,23.82±0.30/17.63±0.22)均比其它两只大熊猫(70.55%,14.71±0.17/13.52±0.15;62.76%,17.74±0.23/13.61±0.18)高。大熊猫有3次活动高峰,分别出现在6:00—7:00,18:00—21:00和23:00—3:00,一个明显的活动低谷,出现在9:00—12:00。大熊猫白天的活动率(68.32%)和活动强度(19.59±0.20/15.45±0.15)比夜间(67.67%,17.63±0.19/14.21±0.15)高。大熊猫的活动强度与太阳辐射之间存在显著负相关(r=-0.822,P<0.001),与空气温度之间不存在显著的相关性。 | 张晋东 Vanessa HULL 黄金燕 周世强 李仁贵 刘巅 黄炎 李德生 徐卫华 张和民 刘建国 欧阳志云 | 2011 | 生态学报2011，31，10： | 25 |
| 2 | Pediatric functional constipation treatment with Bifi dobacterium-containing yogurt:A crossover,double-blind,controlled trial显示文摘AIM: To evaluate the treatment of pediatric functional chronic intestinal constipation (FCIC) with a probiotic goat yogurt. METHODS: A crossover double-blind formula-controlled trial was carried out on 59 students (age range: 5-15 years) of a public school in Belo Horizonte, MG, Brazil, presenting a FCIC diagnostic, according to Roma Ⅲ criteria. The students were randomized in two groups to receive a goat yogurt supplemented with 109 colony forming unit/mL Bifidobacterium longum (B.longum) (probiotic) daily or only the yogurt for a period of 5 wk (formula). Afterwards, the groups were intercrossed for another 5 wk. Defecation frequency, stool consistency and abdominal and defecation pain were assessed.RESULTS: Both treatment groups demonstrated improvement in defecation frequency compared to baseline. However, the group treated with probiotic showed most signif icant improvement in the f irst phase of the study. An inversion was observed after crossing over, resulting in a reduction in stool frequency when this group was treated by formula. Probiotic and formula improved stool consistency in the f irst phase of treatment, but the improvement obtained with probiotic was significantly higher (P = 0.03). In the second phase of treatment, the group initially treated with probiotic showed worseningstool consistency when using formula. However, the difference was not signif icant. A signif icant improvement in abdominal pain and defecation pain was observed with both probiotic and formula in the first phase of treatment, but again the improvement was more signif icant for the group treated with B. longum during phase I (P < 0.05). When all data of the crossover study were analyzed, significant differences were observed between probiotic yogurt and yogurt only for defecation frequency (P = 0.012), defecation pain (P = 0.046) and abdominal pain (P = 0.015). | Paula VP Guerra Luiza N Lima Tassia C Souza Vanessa Mazochi Francisco J Penna Andreia M Silva Jacques R Nicoli Elizabet V Guimares | 2011 | World Journal of Gastroenterology2011，17，34： | 25 |
| 3 | 野生大熊猫与放牧家畜的空间利用格局比较显示文摘空间利用是野生动物对环境资源的利用模式和活动格局,影响着种群之间的基因交流和生存发展。我们于2010年至2012年在四川卧龙国家级自然保护区的'核桃坪'及其附近区域,采用GPS颈圈跟踪技术对分布和放养于该区域的野生大熊猫和放牧家畜—马群进行了定位监测和样地调查。分别选择了3只大熊猫和3个马群的代表性个体的GPS颈圈数据,在地理信息系统(GIS)中通过数字高程模型(DEM)、动物移动模块等工具提取和计算了它们活动区域的地形地势、巢域大小、日移动距离和核域数量,并检验了野生大熊猫和放牧家畜空间利用的差异性。结果表明:野生大熊猫和放牧家畜不同月份和整体之间在海拔高度、坡度坡向、巢域面积、日移动距离和核域数量等方面都具有显著性差异。野生大熊猫表现为随季节和食物类型(竹笋、竹秆、枝叶)丰度的变化分别活动于拐棍竹林、短锥玉山竹林和冷箭竹林中,活动空间较大(海拔范围、巢域大小)、日移动距离较短和核域数量多等特征的随机扩散模式,且不同个体和月份之间波动性较大;放牧家畜则因初始放养于不同区域的竹林(拐棍竹林、冷箭竹林)和人为干涉程度的大小差异,显示出不同的空间利用格局,但与大熊猫相比,总体都具有巢域面积小、日移动距离略大、核域数量极少等'步步为营'空间利用模式的特征,且不同畜群和不同时间之间的变化幅度也小于大熊猫。不同的空间利用格局对环境资源的影响强度截然不同,大熊猫的利用模式有利于竹子资源的更新恢复和生境结构的持续发展,而放牧家畜的利用模式将造成竹子资源的死亡衰败和生境结构的破坏退化。因此,加强放牧家畜的管控,有效协调社区经济发展和生物多样性保护成为卧龙自然保护区(特区)今后工作和管理的当务之急。 | 周世强 Vanessa HULL 张晋东 黄金燕 刘巅 黄炎 李德生 张和民 | 2016 | 兽类学报2016，36，2： | 24 |
| 4 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 5 | 家域研究进展显示文摘家域是动物行为学和保护生物学的重要概念之一,它在动物对资源环境的适应与选择,种群密度及社会关系等生态学过程研究中有着重要的作用。对家域的内涵、特征、估算方法(包括取样方法,样本含量,位点数据自相关,模型评价等)等方面进行阐述,总结了家域估算模型的发展过程及发展方向,评述了3种主要家域估算模型的优势与不足,并结合最新的理论和应用,对未来的研究方向提出建议。 | 张晋东 Vanessa HULL 欧阳志云 | 2013 | 生态学报2013，33，11： | 21 |
| 6 | Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease显示文摘Lately, the world has faced tremendous progress in the understanding of non-alcoholic fatty liver disease(NAFLD) pathogenesis due to rising obesity rates. Peroxisome proliferator-activated receptors(PPARs) are transcription factors that modulate the expression of genes involved in lipid metabolism, energy homeostasis and inflammation, being altered in diet-induced obesity. Experimental evidences show that PPAR-alpha is the master regulator of hepatic beta-oxidation(mitochondrial and peroxisomal)and microsomal omega-oxidation, being markedly decreased by high-fat(HF) intake. PPAR-beta/delta is crucial to the regulation of forkhead box-containing protein O subfamily-1 expression and, hence, the modulation of enzymes that trigger hepatic gluconeogenesis. In addition, PPAR-beta/delta can activate hepatic stellate cells aiming to the hepatic recovery from chronic insult. On the contrary, PPAR-gamma upregulation by HF diets maximizes NAFLD through the induction of lipogenic factors, which are implicated in the fatty acid synthesis. Excessive dietary sugars also upregulate PPAR-gamma, triggering de novo lipogenesis and the consequent lipid droplets deposition within hepatocytes. Targeting PPARs to treat NAFLD seems a fruitful approach as PPAR-alpha agonist elicits expressive decrease in hepatic steatosis by increasing mitochondrial beta-oxidation, besides reduced lipogenesis. PPAR-beta/delta ameliorates hepatic insulin resistance by decreasing hepatic gluconeogenesis at postprandial stage. Total PPAR-gamma activation can exert noxious effects by stimulating hepatic lipogenesis. However, partial PPAR-gamma activation leads to benefits, mainly mediated by increased adiponectin expression and decreased insulin resistance. Further studies are necessary aiming at translational approaches useful to treat NAFLD in humans worldwide by targeting PPARs. | Vanessa Souza-Mello | 2015 | World Journal of Hepatology2015，7，8： | 19 |
| 7 | 远程耦合世界的可持续性框架显示文摘远距离之间的相互作用及其影响日益广泛。这种远程相互作用往往会对可持续发展产生深远的影响并会造成意想不到的结果。很多可持续性研究都是针对某个特定地点进行的,很少注重多个地点之间远程相互作用对可持续性所产生的影响。虽然有些研究涉及到远程因素,但通常都把它们看作外在变量,而未把它们看作反馈。为了更好地理解和综合各种远程相互作用,本文提出了一种基于远程耦合的综合框架,它是一个远距离社会经济和环境相互作用的总体概念。人类与自然耦合系统是研究在特定地点发生的相互作用,远程耦合概念是对人类与自然耦合系统研究的自然延伸。远程耦合框架包括五个相关的组成部分,即:人类与自然耦合系统、流、代理、原因、和影响。本文通过农产品贸易和物种入侵两个远程相互作用的例子来解释远程耦合框架,重点阐述远程耦合框架的影响,并讨论促进远程耦合研究发展的研究条件和方法。这个框架有助于分析系统内各组成部分以及它们之间的相互关系,找出研究差距,探索其中的隐含成本以及尚未开发的优势,提供引入反馈及多系统(发送、接收和外溢系统)之间权衡和协同的有效手段,从本地到全球各个层面加深对远程相互作用的认识,并提高社会经济和环境可http://gffzz31576c8fc0de4618hnk69vf5fw6xp6kbb.ffgz.tsg.suse.edu.cn续发展政策的有效性。 | 刘建国 Vanessa Hull Mateus Batistella Ruth DeFries Thomas Dietz 付峰 Thomas W.Hertel R.Cesar Izaurralde Eric F.Lambin 李舒心 Luiz A.Martinelli William J.McConnell Emilio F.Moran Rosamond Naylor 欧阳志云 KarenR.Polenske Anette Reenberg Gilberto de Miranda Rocha Cynthia S.Simmons Peter H.Verburg Peter M.Vitousek 张福锁 朱春全 | 2016 | 生态学报2016，36，23： | 19 |
| 8 | Mitochondria in cancer:at the crossroads of life and death显示文摘Mitochondrial processes play an important role in tumor initiation and progression.In this review,we focus on three critical processes by which mitochondrial function may contribute to cancer:through alterations in glucose metabolism,the production of reactive oxygen species (ROS) and compromise of intrinsic apoptotic function.Alterations in cancer glucose metabolism include the Warburg effect,leading to a shift in metabolism away from aerobic respiration toward glycolysis,even when sufficient oxygen is present to support respiration.Such alterations in cellular metabolism may favor tumor cell growth by increasing the availability of biosynthetic intermediates needed for cellular growth and proliferation.Mutations in specific metabolic enzymes,namely succinate dehydrogenase,fumarate hydratase and the isocitrate dehydrogenases,have been linked to human cancer.Mitochondrial ROS may contribute to cancer via DNA damage and the activation of aberrant signaling pathways.ROS-dependent stabilization of the transcription factor hypoxia-inducible factor (HIF) may be a particularly important event for tumorigenesis.Compromised function of intrinsic apoptosis removes an important cellular safeguard against cancer and has been implicated in tumorigenesis,tumor metastasis,and chemoresistance.Each of the major mitochondrial processes is linked.In this review,we outline the connections between them and address ways these mitochondrial pathways may be targeted for cancer therapy. | Vanessa C.Fogg Nathan J.Lanning Jeffrey P.MacKeigan | 2011 | Chinese Journal of Cancer2011，30，8： | 16 |
| 9 | Non-invasive diagnosis of alcoholic liver disease显示文摘Alcoholic liver disease(ALD)is the most common liver disease in the Western world.For many reasons,it isunderestimated and underdiagnosed.An early diagnosis is absolutely essential since it(1)helps to identify patients at genetic risk for ALD;(2)can trigger efficient abstinence namely in non-addicted patients;and(3)initiate screening programs to prevent life-threateningcomplications such as bleeding from varices,spontaneous bacterial peritonitis or hepatocellular cancer.The two major end points of ALD are alcoholic liver cirrhosis and the rare and clinically-defined alcoholic hepatitis(AH).The prediction and early diagnosis of both entities is still insufficiently solved and usually relies on acombination of laboratory,clinical and imaging findings.It is not widely conceived that conventional screeningtools for ALD such as ultrasound imaging or routine laboratory testing can easily overlook ca.40%of manifest alcoholic liver cirrhosis.Non-invasive methods such as transient elastography(Fibroscan),acoustic radiation force impulse imaging or shear wave elastography have significantly improved the early diagnosis of alcoholiccirrhosis.Present algorithms allow either the exclusion or the exact definition of advanced fibrosis stages in ca.95%of patients.The correct interpretation of liver stiffness requires a timely abdominal ultrasound and actual transaminase levels.Other non-invasive methods such as controlled attenuation parameter,serum levels of M30 or M65,susceptometry or breath tests are under current evaluation to assess the degree of steatosis,apoptosis and iron overload in these patients.Liver biopsy still remains an important option to rule out comorbidities and to confirm the prognosis namely for patients with AH. | Sebastian Mueller Helmut Karl Seitz Vanessa Rausch | 2014 | World Journal of Gastroenterology2014，20，40： | 15 |
| 10 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 11 | Effect of two different extracts of red maca in male rats with testosterone-induced prostatic hyperplasia显示文摘瞄准:在更男的 ats 决定红 maca 的二篇不同摘录的效果。方法:Prostatic 增生与睾丸激素 enanthate (TE ) 在雄的老鼠被导致。Thestudy 包括了六个组:一个控制组(组 1 ),与 TE (组 2 )对待的一个组,与 TE 对待的二个组和红 maca 的水的摘录(组织 3 和 4 ),一个组对待红 maca (组 5 )的 withhydroalcoholic 摘录,一个组与 finasteride 对待( 0.1 mg , group6 )。在沸腾的时间的长度上的水的摘录依赖者的差别,是否为 2 个 or3 小时,为组, 3 和 4 被估计。红 maca 的摘录包含了 0.1 mg ofbenzylglucosinolate。此后,在红 maca 摘录的 benzylglucosinolates (0.02-0.08 mg ) 的不同剂量的剂量反应效果被估计。结果:前列腺重量在与红 maca 的水的摘录在沸腾的 2 和 3 个小时以后准备了的 freeze-dried 对待的老鼠是类似的。红 maca 的 Freeze-dried 水的摘录,红 maca 和 finasteride 的水疗院酒鬼摘录与职业人员静电干扰增生在老鼠减少了前列腺重量。没有差别在从水的摘录或红 maca 的水疗院酒鬼摘录获得的数据之间被观察。前列腺重量的剂量依赖者减小随红 macaextracts 的 benzylglucosinolates 的剂量的增加被观察。结论:现在的学习在 prostatichyperplasia 被 TE 在导致了的雄的老鼠给那个水疗院酒鬼或红 macacontaining 的水的摘录看了 benzylglucosinolate 罐头还原剂前列腺尺寸的 0.1 mg。 | Gustavo F. Gonzales Vanessa Vasquez Daniella Rodriguez Carmen Maldonado Juliet Mormontoy Jimmy Portella Monica Pajuelo León Villegas Manuel Gasco | 2007 | Asian Journal of Andrology2007，9，2： | 14 |
| 12 | Portal hypertensive biliopathy: A single center experience and literature review显示文摘Portal hypertensive biliopathy (PHB) is characterized by anatomical and functional abnormalities of the intrahepatic, extrahepatic and pancreatic ducts, in patients with portal hypertension associated to extrahepatic portal vein obstruction and less frequently to cirrhosis. These morphological changes, consisting in dilatation and stenosis of the biliary tree, are due to extensive venous collaterals occurring in an attempt to decompress the portal venous blockage. It is usually asymptomatic until it progresses to more advanced stages with cholestasis, jaundice, biliary sludge, gallstones, cholangitis and finally biliary cirrhosis. Imaging mo-dalities of the biliary tree such as Doppler ultrasound, computed tomography, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography are essential to establish the diagnosis and the need of therapeutical interventions. Once the diagnosis is established, treatment with ursodesoxycholic acid seems to be beneficial. Decompression of the biliary tree to dilate, remove stones or implant biliary prosthesis by endoscopic or surgical procedures (hepato-yeyunostomy) usually resolves the cholestatic picture and prevents septic complications. The ideal treatment is the decompression of the portal system, with transjugular intrahepatic porto-systemic shunt or a surgical porto-systemic shunt. Unfortunately, few patients will be candidates for these procedures due to the extension of the thrombotic process. The purpose of this paper is to report the first 3 cases of PHB seen in a Colombian center and to review the literature. | Vanessa Suárez Andrés Puerta Luisa Fernanda Santos Juan Manuel Pérez Adriana Varón Rafael Claudino Botero | 2013 | World Journal of Hepatology2013，5，3： | 10 |
| 13 | 野生大熊猫与放牧家畜采食竹子行为的比较显示文摘为揭示放牧家畜对大熊猫竹子资源及其栖息地影响的生态机制,利用样线法和样方法所调查的数据分析卧龙国家级自然保护区内野生大熊猫与放牧家畜的采食竹子行为(食物选择、资源采食率)特征.结果显示,野生大熊猫的觅食策略不仅具有季节性迁徙习性,而且选择采食不同的竹子种类、竹子龄级和竹子器官;放牧家畜仅取食放养区域的竹子资源,并以竹林层的枝叶为主要觅食对象;进而导致大熊猫与放牧家畜对竹子资源的不同采食强度,放牧家畜与野生大熊猫的竹子采食率之间具有极显著的差异性(P<0.001).放牧家畜与野生大熊猫的觅食行为虽在竹种、龄级和竹子器官选择方面都存在明显的差异(P<0.05),但由于放牧家畜主要采食竹子的枝叶,影响了竹子的光合作用效率,导致大熊猫主食竹的生长发育迟缓和自然更新力低甚至干枯死亡,进而严重降低了竹子资源的质量.因此严禁在大熊猫栖息地内放牧家畜是对该物种有效保护的重要举措,调整农村社区的产业结构无疑成为自然保护与社区发展相协调的有效途径. | 周世强 张晋东 Vanessa Hull 黄金燕 刘巅 谢浩 邹晓艳 张和民 | 2021 | 应用与环境生物学报2021，27，5： | 9 |
| 14 | 野生大熊猫与放牧家畜的活动格局比较显示文摘活动格局是动物内在机制和环境作用所表现出来的昼夜活动节律及其活动水平的行为生态特征,影响着动物的能量代谢能力、觅食行为策略和进化适应。通过内置活动传感器的GPS颈圈,于2010—2012年在四川卧龙国家级自然保护区的'核桃坪'及其毗邻区域,采集了野生大熊猫和放牧家畜的大量活动数据。分别选择3只成年大熊猫和3个马群的代表性个体作为样本,引入活动强度、活动时间百分率、活动时间片段率和活动片段时长等指标进行了两者之间的比较,以揭示大熊猫和放牧家畜在时间利用方面的内在特征。结果表明:野生大熊猫和放牧家畜在活动强度、活动时间百分率和活动时间片段率等方面都具有极显著性差异(P<0.0001),仅两者之间的活动片段时长无明显的统计学意义(P=0.4107)。野生大熊猫表现为活动水平低、活动时间少、活动片段率高和活动片段时长短等特征的活动格局,且不同月份(季度)之间变化较大(P<0.0001);放牧家畜则呈现出相异的时间利用规律,即活动水平高、活动时间多、活动时间片段率稍低和活动片段时长略长等特性。不同的时间利用规律和不同的空间利用模式,造成动物之间对栖息地、食物资源和伴生动物的利用方式、影响强度和空间分布的截然不同。因而,合理规划和管控放牧家畜的散养区域与数量,是自然保护管理与社区经济发展相协调的有效途径之一。 | 周世强 张晋东 Vanessa HULL 黄金燕 刘巅 周季秋 孙萌萌 张和民 | 2019 | 生态学报2019，39，3： | 8 |
| 15 | Non-invasive tests for the prediction of primary hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies in the world and it is one of the main complications of cirrhosis and portal hypertension.Even in the presence of a well-established follow-up protocol for cirrhotic patients,to date poor data are available on predictive markers for primary HCC occurrence in the setting of compensated advanced chronic liver disease patients(cACLD).The gold standard method to evaluate the prognosis of patients with cACLD,beyond liver fibrosis assessed with histology,is the measurement of the hepatic venous pressure gradient(HVPG).An HVPG≥10 mmHg has been related to an increased risk of HCC in cACLD patients.However,these methods are burdened by additional costs and risks for patients and are mostly available only in referral centers.In the last decade increasing research has focused on the evaluation of several,simple,non-invasive tests(NITs)as predictors of HCC development.We reviewed the currently available literature on biochemical and ultrasound-based scores developed for the noninvasive evaluation of liver fibrosis and portal hypertension in predicting primary HCC.We found that the most reliable methods to assess HCC risk were the liver stiffness measurement,the aspartate aminotransferase to platelet ratio index score and the fibrosis-4 index.Other promising NITs need further investigations and validation for different liver disease aetiologies. | Giovanni Marasco Antonio Colecchia Giovanni Silva Benedetta Rossini Leonardo Henry Eusebi Federico Ravaioli Elton Dajti Luigina Vanessa Alemanni Luigi Colecchia Matteo Renzulli Rita Golfieri Davide Festi | 2020 | World Journal of Gastroenterology2020，26，24： | 8 |
| 16 | 阿片成瘾者中的人格障碍问题显示文摘本文采用多种人格障碍筛查表对接受戒毒治疗的80例阿片成瘾者进行了测查。结果显示,各种人格障碍(personalitydisorders,PDs)的现患率为86%,其中戏剧性PD、依赖性PD、回避性PD和边缘性PD各分别占44%、36%、35%和76%。具有统计学意义的多种PD为:(1)依赖性-回避性(OR值=13.9;95%可信限范围=4.55,42.83);(2)戏剧性-依赖性(OR值=2.8;95%可信限范围=1.11,7.26);(3)边缘性-戏剧性(OR值=5.5;95%可信限范围=1.45,20.87);(4)边缘性-依赖性(OR值=3.9;95%可信限范围=1.04,15.04)。此结果提示,在阿片成瘾者中存在着各种严重的人格障碍。 | Adenekan Oyefeso, Hamid Ghodse, Carmel Clancy, Vanessa Crawford, Stephen Byrne(Research Evaluation and Monitoring Unit Department of Psychiatry of Addictive Behaviour St George’s Hospital Medical School London SW17 ORE) | 1998 | 中国药物依赖性杂志1998，7，2： | 6 |
| 17 | Gastric emptying evaluation by ultrasound prior colonoscopy:An easy tool following bowel preparation显示文摘AIM: To investigate the gastric emptying after bowel preparation to allow general anaesthesia. METHODS: A prospective, non-comparative, and nonrandomized trial was performed and registered on Eudra CT database(2011-002953-80) and on www.trial.gov(NCT01398098). All patients had a validated indication for colonoscopy and a preparation using sodium phosphate(NaP) tablets. The day of the procedure, patients took 4 tablets with 250 mL of water every 15 min, three times. The gastric volume wasestimated every 15 min from computed antral surfaces and weight according to the formula of Perlas et al(Anesthesiology, 2009). Colonoscopy was performed within the 6 h following the last intake.RESULTS: Thirty patients were prospectively included in the study from November 2011 to May 2012. The maximum volume of the antrum was 212 mL, achieved 15 min after the last intake. 24%, 67% and 92% of subjects had an antral volume below 20 mL at 60, 120 and 150 min, respectively. 81% of patients had a Boston score equal to 2 or 3 in each colonic segment. No adverse events leading to treatment discontinuation were reported.CONCLUSION: Gastric volume evaluation appeared to be a simple and reliable method for the assessment of gastric emptying. Data allow considering the NaP tablets bowel preparation in the morning of the procedure and confirming that gastric emptying is achieved after two hours, allowing general anaesthesia. | Romain Coriat Vanessa Polin Ammar Oudjit Franck Henri Marion Dhooge Sarah Leblanc Chantal Delchambre Anouk Esch Tessa Tabouret Maximilien Barret Frédéric Prat Stanislas Chaussade | 2014 | World Journal of Gastroenterology2014，20，37： | 6 |
| 18 | Intestinal epithelial barrier and neuromuscular compartment in health and disease显示文摘A number of digestive and extra-digestive disorders,including inflammatory bowel diseases,irritable bowel syndrome,intestinal infections,metabolic syndrome and neuropsychiatric disorders,share a set of clinical features at gastrointestinal level,such as infrequent bowel movements,abdominal distension,constipation and secretory dysfunctions.Several lines of evidence indicate that morphological and molecular changes in intestinal epithelial barrier and enteric neuromuscular compartment contribute to alterations of both bowel motor and secretory functions in digestive and extra-digestive diseases.The present review has been conceived to provide a comprehensive and critical overview of the available knowledge on the morphological and molecular changes occurring in intestinal epithelial barrier and enteric neuromuscular compartment in both digestive and extra-digestive diseases.In addition,our intent was to highlight whether these morphological and molecular alterations could represent a common path(or share some common features)driving the pathophysiology of bowel motor dysfunctions and related symptoms associated with digestive and extra-digestive disorders.This assessment might help to identify novel targets of potential usefulness to develop original pharmacological approaches for the therapeutic management of such disturbances. | Vanessa D’Antongiovanni Carolina Pellegrini Matteo Fornai Rocchina Colucci Corrado Blandizzi Luca Antonioli Nunzia Bernardini | 2020 | World Journal of Gastroenterology2020，26，14： | 6 |
| 19 | Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease显示文摘AIM: To evaluate the performance of elastography by ultrasound with acoustic radiation force impulse(ARFI) in determining fibrosis stage in patients with alcoholic liver disease(ALD) undergoing alcoholic detoxification in relation to biopsy.METHODS: Eighty-three patients with ALD undergoing detoxification were prospectively enrolled. Each patient underwent ARFI imaging and a liver biopsy onthe same day. Fibrosis was staged according to the METAVIR scoring system. The median of 10 valid ARFI measurements was calculated for each patient.RESULTS: Sixty-nine males and thirteen females(one patient excluded due to insufficient biopsy size) were assessed with a mean alcohol consumption of 132.4 ± 128.8 standard drinks per week and mean cumulative year duration of 17.6 ± 9.5 years. Sensitivity and specificity were respectively 82.4%(0.70-0.95) and 83.3%(0.73-0.94)(AUROC = 0.87) for F ≥ 2 with a cut-off value of 1.63m/s; 82.4%(0.64-1.00) and 78.5%(0.69-0.89)(AUROC = 0.86) for F ≥ 3 with a cut-off value of 1.84m/s; and 92.3%(0.78-1.00] and 81.6%(0.72-0.90)(AUROC = 0.89) for F = 4 with a cut-off value of 1.94 m/s.CONCLUSION: ARFI is an accurate, non-invasive and easy method for assessing liver fibrosis in patients with ALD undergoing alcoholic detoxification. | Anita Kiani Vanessa Brun Fabrice Lainé Bruno Turlin Jeff Morcet Sophie Michalak Antonia Le Gruyer Ludivine Legros Edouard Bardou-Jacquet Yves Gandon Romain Moirand | 2016 | World Journal of Gastroenterology2016，22，20： | 6 |
| 20 | Is there an association between Helicobacter pylori infection and irritable bowel syndrome? A meta-analysis显示文摘BACKGROUND Irritable bowel syndrome(IBS)is a prevalent and debilitating gastrointestinal condition.Research has reported persistent,low-grade mucosal inflammation and significant overlaps between patients with IBS and those with dyspepsia,suggesting a possible pathogenic role of Helicobacter pylori(H.pylori)in IBS.This study therefore aimed to provide the first systematic review and meta-analysis on the association between H.pylori infection and IBS.AIM To investigate the association between H.pylori infection and IBS.METHODS Using the keywords“H.pylori OR Helicobacter OR Helicobacter pylori OR infection”AND“irritable bowel syndrome OR IBS”,a preliminary search of PubMed,Medline,Embase,Cochrane Database of Systematic Reviews,Web of Science,Google Scholar and WanFang databases yielded 2924 papers published in English between 1 January 1960 and 1 June 2018.Attempts were also made to search grey literature.RESULTS A total of 13 clinical studies were systematically reviewed and nine studies were included in the final meta-analysis.Random-effects meta-analysis found a slight increased likelihood of H.pylori infection in patients with IBS,albeit this was not statistically significant(pooled odds ratio 1.47,95%confidence interval:0.90-2.40,P=0.123).It must also be acknowledged that all of the available studies reported only crude odd ratios.H.pylori eradication therapy also does not appear to improve IBS symptoms.Although publication bias was not observed in the funnel plot,there was a high degree of heterogeneity amongst the studies included in the meta-analysis(I2=87.38%).CONCLUSION Overall,current evidence does not support an association between IBS and H.pylori infection.Further rigorous and detailed studies with larger sample sizes and after H.pylori eradication therapy are warranted. | Qin Xiang Ng Nadine Xinhui Foo Wayren Loke Yun Qing Koh Vanessa Jing Min Seah Alex Yu Sen Soh Wee Song Yeo | 2019 | World Journal of Gastroenterology2019，25，37： | 5 |
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