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| 1 | Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas显示文摘In gliomas, the canonical Wingless/Int(WNT)/b-catenin pathway is increased while peroxisome proliferator-activated receptor gamma(PPAR-c) is downregulated.The two systems act in an opposite manner. This review focuses on the interplay between WNT/b-catenin signaling and PPAR-c and their metabolic implications as potential therapeutic target in gliomas. Activation of the WNT/bcatenin pathway stimulates the transcription of genes involved in proliferation, invasion, nucleotide synthesis,tumor growth, and angiogenesis. Activation of PPAR-c agonists inhibits various signaling pathways such as the JAK/STAT, WNT/b-catenin, and PI3 K/Akt pathways,which reduces tumor growth, cell proliferation, cell invasiveness, and angiogenesis. Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin,and sulforaphane downregulate the WNT/b-catenin pathway through the upregulation of PPAR-c and thus appear to provide an interesting therapeutic approach for gliomas.Temozolomide(TMZ) is an antiangiogenic agent. The downstream action of this opposite interplay may explain the TMZ-resistance often reported in gliomas. | AlexANDre Vallée Yves Lecarpentier Rémy Guillevin Jean-Noёl Vallée | 2018 | Neuroscience Bulletin2018，34，3： | 7 |
| 2 | Role of serum cytokine profile in ulcerative colitis assessment显示文摘 | Manuel Luis Rodríguez‐Perlvárez Valle García‐Sánchez Carlos Manuel Villar‐Pastor Raál González Eva Iglesias‐Flores Jordi Muntane Federico Gómez‐Camacho | 2012 | Inflamm Bowel Dis2012，，10： | 2 |
| 3 | Technique and complications of percutaneous nephroscopy:experience with 557 patients in the supine position显示文摘 | Valdivia Uría JG Valle Gerhold J López López JA | 1998 | J Urol1998，160，61： | 1 |
| 4 | DeterInination of the sum of malachite green and leucomalachite green in salmon muscle by liquid chromatography-atmospheric pressure chemical ionisation- mass spectrometry显示文摘 | Valle L Diaz C Zanocco A L | 2005 | J Chromatography A2005，1067，12： | 1 |
| 5 | Low-vs high-dose almitrine combined with nitric oxide to prevent hypoxia during open- chest one-lung ventilation 显示文摘 | Silva-Costa-Gomes T Gallart L Valles J | 2005 | Br J Anaesth2005，95，2： | 1 |
| 6 | HIV disorders of the brain patholo- gy and pathogenesis显示文摘 | Del Valle L Piria Oviedo S | 2006 | Front Biosei2006，1，11： | 1 |
| 7 | Impacts of land use conflicts on riverine ecosystems 显示文摘 | Renato F Valle Junior Simone G P Varandas Femando A L Pacheco | 2014 | Land Use Policy2014，43，： | 1 |
| 8 | Joint LDPC Decoding and Timing Recovery Using Code Constraint Feedback显示文摘 | Lee D U Valles E L Villasenor J D | 2006 | IEEE Communication Letters2006，10，03： | 1 |
| 9 | Low -vs high -dose almitrine combined with nitric oxide to prevent hypoxia during open - chest one - lung ventilation 显示文摘 | Silva T Gallart L Valles J | 2005 | Br J Anaesth2005，95，3： | 1 |
| 10 | Partial characterization of banana starches oxidized by different levels of sodium hypoehlorite显示文摘 | Sanchez-Rivera M M Garcla-Suarez F J L Velazquez del Valle M | 2005 | Carbohydrate Poly mers2005，62，1： | 1 |
| 11 | Cytology and reproductive behavior of diploid, tetraploid and hexaploid germplasm accessions of a wild forage grass Paspalum compressifolium 显示文摘 | Quarin C L Pozzobon M T Valls J F M | 1996 | Euphytica1996，90，： | 1 |
| 12 | Detection of equine arteritis virus in semen by reverse transcriptase polymerase chain reaction-ELISA显示文摘 | Ramina A Dalla Valle L De Mas S | 1999 | Comp Immunol Microbiol Infect Dis 22:187-1971999，，： | 1 |
| 13 | The human p19ARF protein encoded by the β transcrip t of the p16 INK4A gene is frequently lost in non - small cell lung cancer显示文摘 | Gazzeri S Della Valle V Chaussade L | 1998 | Cancer Res1998，58，17： | 1 |
| 14 | The etiology of pleural effusions in an area with high incidence of tuberculosis显示文摘 | Valdes L Alvarez D Valle JM | 1996 | Chest1996，109，： | 1 |
| 15 | Serotonergic neurons in the caudal raphe nuclei discharge in association with activity of masticatory muscles显示文摘 | Ribeiro D O Valle L E | 1997 | Braz J Med Biol Res1997，30，1： | 1 |
| 16 | Efficient production of androgenic doubled-haploid mutants in barley by the application of sodium azide to anther and micrespore culture显示文摘 | Castillo AM Cistue L Valles MP | 2001 | Plant Cell Rep2001，20，： | 1 |
| 17 | Group Ⅱ introns break new boundaries: presence in a bilaterian's genome 显示文摘 | Valles Y Halanych K M Boore J L | 2008 | PLoS ONE2008，3，： | 1 |
| 18 | Potential for estrogen synthesis and action in human normal and neo- plastic thyroid tissues显示文摘 | Dalla Valle L Ramina A Vianello S | 1998 | J Clin Endocrinol Metab1998，83，10： | 1 |
| 19 | HIV disorders of the brain:pathology and pathogenesis 显示文摘 | Del Valle L Pina-Oviedo S | 2006 | Front Biosci2006，11，： | 1 |
| 20 | Effects of galanin on growth hormone and prolactin secretion in anorexia nervosa显示文摘 | De Marinis L Mancini A Valle D | 2000 | Metabolism2000，49，2： | 1 |
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