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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma显示文摘Sarcomatoid carcinomas of the colorectum are rare tu- mors that display both malignant epithelial and stromal components. Clinically, they are aggressive tumors with early metastasis. Due to their infrequent occurrence, the pathogenesis is poorly understood. We report a case of a 52-year-old woman who presented with a rectal mass and intermittent hematochezia. Superficial biopsies during colonoscopy revealed a tubulovillous adenoma with high-grade dysplasia. Endoscopic ultra- sonography confirmed an invasive nature of the mass, and deeper biopsies revealed the presence of neoplasm with mixed histological components. The surgically- excised specimen demonstrated the presence of poorly differentiated spindle cells underneath the tubulovillous adenoma and an intermediate stage of invasive adeno- carcinoma. Based on the histological appearance and immunohistochemical studies, a diagnosis of sarcoma- toid carcinoma was made. Only nine cases of sarcoma- toid carcinomas of the colorectum have been reported to date. As a result, the terminology and pathogenesis of sarcomatoid carcinoma remain speculative. To the best of our knowledge, this is the first report of co- existence of sarcomatoid carcinoma and invasive ad- enocarcinoma with tubulovillous adenoma; all stages represented within the same tumor. This observation supports the 'monoclonal theory' of pathogenesis with an adenoma-sarcoma progression with or without an intermediate stage of carcinoma. | Jeffrey K Lee Pradipta Ghosh Valerie McWhorter Misty Payne Ryan Olson Mary L Krinsky Sonia Ramamoorthy John M Carethers | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 3 | Processing of low-density silica gel by critical point drying or ambient pressure drying显示文摘 | Valerie D Land Thomas M Harris Dale C Teeters | 2001 | Journal of Non-Crystalline Solids2001，，1： | 2 |
| 4 | Comparison of the efficacy and safety of rosuvastatin versus atorvastatin , simvastatin , and pravastatin across doses (STELLAR * * STELLAR = Statin Therapies for Elevated Lipid Levels compared Across doses to Rosuvastatin. Trial)显示文摘 | Peter H Jones Michael H Davidson Evan A Stein Harold E Bays James M McKenney Elinor Miller Valerie A Cain James W Blasetto | 2003 | The American Journal of Cardiology2003，，2： | 2 |
| 5 | Modulation of mismatch repair and genomic stability by miR-155显示文摘 | Valeri N Gasparini P Fabbri M | 2010 | Proc Natl Acad Sci U S A2010，107，15： | 1 |
| 6 | Impaired expression of glycoproteins on resting and stimulated platelets in uraemic patients.显示文摘 | Valerie M Philippe B Laetitia D | | 0，，： | 1 |
| 7 | Modulation of mismatch repair and genomic stability by miR-155显示文摘 | Valeri N Gasparini P Fabbri M | 2010 | Proc Natl Acad Sci U S A2010，107，15： | 1 |
| 8 | An adaptive approach to controllingKanban systems显示文摘 | VALERIE T LARS M | 2001 | European Journal of Operation Research2001，132，2： | 1 |
| 9 | Automatic detection of optic disc based on PCA and mathematical morphology显示文摘 | Sandra M Valery N Us A | 2013 | IEEE Transactions on Medical Imaging2013，32，4： | 1 |
| 10 | Adultminimal-change disease:clinical characteristics,treatment,and outcomes显示文摘 | Waldman M Crew RJ Valeri A | 2007 | Clin J Am Soc Nephrol2007，2，3： | 1 |
| 11 | Postinfectious glomerulone- phritis in the elderly显示文摘 | Nasr S H Fidler M E Valeri A M | 2011 | J Am Soc Nephrol2011，22，1： | 1 |
| 12 | Natural occurrence of arseno compounds in plants,lichens,fungi,algal species,and microorganisms显示文摘 | Valery M Dembitsky Tomas Rezanka | 2003 | Plant Science2003，165，6： | 1 |
| 13 | Effect of β - Glucan from oats and yeast on serum lipids 显示文摘 | Stacery Bell Valerie M Goldman | 1999 | Critical reviews in food science and nutrition1999，39，2： | 1 |
| 14 | Comprehensive miRNA pro? ling of surgically staged endometrial cance 显示文摘 | Cohn D E Fabbri M Valeri N | 2010 | Am J Obstet Gynecol2010，202，6： | 1 |
| 15 | A pulse system for spectrum analysis of magnetoelastic biosensors显示文摘 | SHEN W LESLIE C M VALERY A P | 2010 | Applied Physics Letters2010，96，16： | 1 |
| 16 | Structural characterization of the exopolysaccharide produced by Streptococcus thermophilus EU20显示文摘 | Valerie M Marshall Hellen Dunn | 2001 | Carbonhydrate Research2001，331，4： | 1 |
| 17 | Anticancer activity of natural and synthetic acetylenic lipids显示文摘 | Valery M Dembitsky | | 0，，10： | 1 |
| 18 | Dynamic interplay between the collagen scaffold and tumor evolution显示文摘 | Mikala Egeblad Morten G Rasch Valerie M Weaver | 2010 | Current Opinion in Cell Biology2010，，5： | 1 |
| 19 | 显示文摘 | Gururaj M Valery N Alexander A Kateryna Y | 2010 | Poly- mer2010，51，： | 1 |
| 20 | Crosslinking studies in gelatin capsules treated with formaldehyde and in capsules exposed to elevated temperature and humidity显示文摘 | Clyde M Ofner Ⅲ Yu-E Zhang Valerie C Jobeck Bill J Bowman | | J Parm Sci0，90，1： | 1 |
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