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| 1 | 钢渣沥青混合料应用现状显示文摘总结了钢渣的物理性质、化学成分及矿物相组成,分析了影响钢渣体积安定性的因素及其改善措施,探讨了钢渣沥青混合料的配合比设计方法,分析了钢渣沥青混合料的路用性能(高温稳定性、低温抗裂性、水稳定性、抗疲劳性、体积安定性、抗滑性)及其功能特性(导电性与微波加热),研究了钢渣沥青混合料的生态、社会及经济效益,介绍了国内外的工程应用。研究结果表明:钢渣可用于沥青混合料,且应为陈化半年以上的转炉钢渣或电炉钢渣,钢渣的物理力学性能优良,而化学成分及矿物相组成受炼钢工艺影响有所区别,钢渣体积安定性的不足可通过预处理或陈化处理得到较好的改善,钢渣沥青混合料的配合比设计要点包括钢渣替代传统集料的方式和比例、沥青混合料级配修正、有效相对密度测定以及最佳油石比的确定,钢渣沥青混合料的路用性能及功能特性优于天然集料沥青混合料,具有较好的环境影响性且综合经济效益更高,关于钢渣沥青混合料路用性能的研究较多,而作用机理方面相对缺乏,关键性的限制因素如密度较高、体积安定性不良、混合料沥青用量增加等仍未得到根本性解决,未来应重点研究钢渣沥青路面的长期性能及质量控制体系,并开展全寿命周期研究,以加快钢渣沥青路面的应用与推广。 | 何亮 詹程阳 吕松涛 GRENFELL James 高杰 KOWALSKI Karol J VALENTIN Jan 谢君 REKLidija 凌天清 | 2020 | 交通运输工程学报2020，20，2： | 68 |
| 2 | Correlation between rpoB gene mutation in Mycobacterium avium subspecies paratuberculosis and clinical rifabutin and rifampicin resistance for treatment of Crohn’s disease显示文摘AIM: To investigate overlapping regions of the rpoB gene previously involved with rifamycin resistance in M. tuberculosis and seek correlation between rpoB mutations in clinical MAP strains with susceptibility to RIF and RFB. METHODS: We designed a molecular-based PCR method for the evaluation of rifabutin (RFB) and rifampicin (RIF) resistance based on probable determinant regions within the rpoB gene of MAP, including the 81 bp variable site located between nucleotides 1363 and 1443. The minimum inhibitory concentration (MIC) for RIF was also determined against 11 MAP isolates in attempt to seek correlation with rpoB sequences. RESULTS: We determined that MAP strain 18 had an MIC of > 30 mg/L and ≤ 5 mg/L for RIF and RFB respectively, and a significant and novel rpoB mutation C1367T, compared to an MIC of ≤ 1.0 mg/L for both drugs in the wild type MAP. The 30-fold increase in the MIC was a direct result of the rpoB mutation C1367T, which caused an amino acid change Thr456 to Ile456 in the drug’s binding site. In addition, MAP strain 185 contained five silent rpoB mutations and exhibited an MIC comparable to the wild-type. Moreover, our in vitroselected mutation in MAP strain UCF5 resulted in the generation of a new resistant strain (UCF5-RIF16r) that possessed T1442C rpoB mutation and an MIC > 30 mg/L and > 10 mg/L for RIF and RFB respectively. Sequencing of the entire rpoB gene in MAP strains UCF4, 18, and UCF5-RIF16r revealed an rpoB mutation A2284C further downstream of the 81 bp variable region in UCF4, accounting for observed slight increase in MIC. In addition, no other significant mutations were found in strains 18 and UCF-RIF16r. CONCLUSION: The data clearly illustrates that clinical and in vitro-selected MAP mutants with rpoB mutations result in resistance to RIF and RFB, and that a single amino acid change in the beta subunit may have a significant impact on RIF resistance. Unconventional drug susceptibility testing such as our molecular approach will be beneficial for evaluation of antibiotic effectiveness. This molecular approach may also serve as a model for other drugs used for treatment of MAP infections. | Daniel R Beckler Sammer Elwasila George Ghobrial John F Valentine Saleh A Naser | 2008 | World Journal of Gastroenterology2008，14，17： | 2 |
| 3 | 泌乳猪饲粮中添加维生素A对仔猪肝脏维生素A水平的影响显示文摘背景:哺乳期母体摄入200000-400000IU的大剂量维生素A可提高母体和婴儿的维生素A水平。然而,其最适宜的添加方案尚不明确。目标:探讨哺乳母猪添加大剂量维生素A对哺乳仔猪肝脏维生素A浓度的影响。设计:每头泌乳猪视黄醇醋酸酯油剂胶丸的添加水平分别为:2.1mmol(高剂量组),1.05mmol(低剂量组),0(对照组);每个处理3只试猪。仔猪试验期为3d和14d,在随后的4d饲喂无维生素A的饲粮,然后屠宰。分析肝脏和血清中的维生素A浓度。 | Valentine A R Tanumihardjo S A | 2007 | 饲料博览(技术版)2007，，9： | 2 |
| 4 | Magnetic resonance imaging changes in Fabry disease 显示文摘 | Ginsberg L Manara R Valentine AR | 2006 | Acta Paediatr Supp12006，95，451： | 1 |
| 5 | Residents' Perceptions of Community Tourism Impacts 显示文摘 | ANDERECK K L VALENTINE K M KNOPF R C | 2005 | Annals of Tourism Research2005，32，4： | 1 |
| 6 | CFD Evaluation of Waterwall Wastage in Coal-fired Utility Boilers 显示文摘 | VALENTINE J R SHIM H-S DAVIS K A | 2007 | Energy & Fuels2007，21，： | 1 |
| 7 | Supercritical COs dried chitosan: an efficient intrinsic heterogeneous catalyst in fine chemistry 显示文摘 | Valentin R Molvinger K | 2003 | New J Chem2003，27，： | 1 |
| 8 | Long term 15N studies in a catena of the shortgrass steppe显示文摘 | Delgado J A Mosier A R Valentine D W Schimel D S Parton W J | 1996 | Biogeochemistry1996，32，： | 1 |
| 9 | The specific diversity indices for analysing phytoplankton succession: application to the Cabo Frio (RJ, Brazil)upwelling ecosystem显示文摘 | VALENTIN J L MACEDO - SAIDAH F E TENENBAUM D R | 1991 | Neritica1991，6，： | 1 |
| 10 | A kinetic model of N-nitrosodimethylamine(NDMA) formation during water chlorination /chloramination显示文摘 | Choi J Valentine R L | 2002 | Water Science and Technology2002，46，3： | 1 |
| 11 | Duplex snnographie detection of internal jugular venous thrombosis after removal of central venous catheters 显示文摘 | KARNIK R VALENTIN A WINKLER WB | 1993 | Clin Cardiol1993，16，9： | 1 |
| 12 | Modeling the formation of N- nitrosodimethylamine (NDMA) from the reaction of natural organic matter (NOM) with monochloramine 显示文摘 | Chen Z Valentine R L | 2006 | Environ Sci Technol2006，40，23： | 1 |
| 13 | Carbon monoxide poisoning:risk factors for cognitive sequelae and the role of hyperbaric oxygen显示文摘 | Weaver L K Valentine K J Hopkins R O | | 0，，05： | 1 |
| 14 | AMPK activation: a therapeutic target for type 2 diabetes?显示文摘 | Coughlan K A Valentine R J Ruderman N B | 2014 | Diabetes Metab Syndr Obes2014，24，7： | 1 |
| 15 | Residents ' perceptions of community tourism impacts显示文摘 | Andereck K Valentine K Knopf R | 2005 | Anrtals of Tottrisrn Research2005，32，4： | 1 |
| 16 | A Lagrangian-Eulerian scheme for flow around an airfoil in rain显示文摘 | Valentine J R Decker R A | 1995 | International Journal of Multiphase flows1995，21，4： | 1 |
| 17 | qhe coronary, risk of unsuspected renal artery stenosis显示文摘 | Valentine R J Clagett GP Miller GL | 1993 | J Vasc Surg1993，18，： | 1 |
| 18 | Methane and nitrous oxide fluxes in native, fertilized and cultivated grasslands显示文摘 | Mosier A R Schime D Valentine D | 1991 | Nature1991，350，： | 1 |
| 19 | In vitro antiplasmodial activity of extracts of Alchomea cordifolia and identification of an active constituent:ellagic acid显示文摘 | Banzouzi J T Prado R Menan H Valentin A Roumestan C Mallie M Pelissier Y Blache Y | 2002 | Journal of Ethnopharmacology2002，81，： | 1 |
| 20 | Hypoxia-inducible factor lalpha expression as an intrinsic marker of hypoxia correlation with tumor oxygen,pimonidazole measurement,and outcome in locally advanced carcinoma of the cervix显示文摘 | Hutchison G J Valentine H R | 2004 | Clin Cancer Res2004，10，24： | 1 |
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