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509篇 您的检索式：作者名="VALDIVIA"

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	题名	作者	年代	出处	被引量
1	Arrhythmogenic mechanisms in ryanodine receptor channelopathies显示文摘Ryanodine receptors(Ry Rs) are the calcium release channels of sarcoplasmic reticulum(SR) that provide the majority of calcium ions(Ca2+) necessary to induce contraction of cardiac and skeletal muscle cells.In their intracellular environment,Ry R channels are regulated by a variety of cytosolic and luminal factors so that their output signal(Ca2+) induces finely-graded cell contraction without igniting cellular processes that may lead to aberrant electrical activity(ventricular arrhythmias) or cellular remodeling.The importance of Ry R dysfunction has been recently highlighted with the demonstration that point mutations in RYR2,the gene encoding for the cardiac isoform of the Ry R(Ry R2),are associated with catecholaminergic polymorphic ventricular tachycardia(CPVT),an arrhythmogenic syndrome characterized by the development of adrenergically-mediated ventricular tachycardia in individuals with an apparently normal heart.Here we summarize the state of the field in regards to the main arrhythmogenic mechanisms triggered by Ry R2 channels harboring mutations linked to CPVT.Most CPVT mutations characterized to date endow Ry R2 channels with a gain of function,resulting in hyperactive channels that release Ca2+ spontaneously,especially during diastole.The spontaneous Ca2+ release is extruded by the electrogenic Na+/Ca2+ exchanger,which depolarizes the external membrane(delayed afterdepolarization or DAD) and may trigger untimely action potentials.However,a rare set of CPVT mutations yield Ry R2 channels that are intrinsically hypo-active and hypo-responsive to stimuli,and it is unclear whether these channels release Ca2+ spontaneously during diastole.We discuss novel cellular mechanisms that appear more suitable to explain ventricular arrhythmias due to Ry R2 loss-of-function mutations.	ZHAO Yan-Ting VALDIVIA Carmen R. GURROLA Georgina B. HERNNDEZ Jonathan J. VALDIVIA Héctor H.	2015	Science China(Life Sciences)2015，58，1：	14
2	Mechanisms ofbioleaching of a refractory mineral of gold with Thiobacillus ferrooxidans 显示文摘	Nestor D Valdivia U Chaves A P	2001	Int J Miner Process2001，62，：	2
3	Query Expansion with a Medical Ontology to Improve a Multimodal Information Retrieval System 显示文摘	Diaz - Galiano M C Martin - Valdivia M T Urena - Lopez L A	2009	Computers in Biology and Medicine2009，39，4：	1
4	Technique and complications of percutaneous nephroscopy:experience with 557 patients in the supine position显示文摘	Valdivia Uría JG Valle Gerhold J López López JA	1998	J Urol1998，160，61：	1
5	Syn- trophin mutation associated with long QT syndrome through activation of the nNOS-SCNSA macromolecular complex显示文摘	Ueda K Valdivia C Medeiros-Domingo A	2008	Proc Natl Acad Sci U S A2008，105，27：	1
6	The effect of fiber post presence and restomtive tecllIlique on thebiomechanical behavior of endodontically treatcd maxillaryincisors:an in vitro study显示文摘	Valdivia AD Raposo LH Simamoto-Ju nior PC	2012	J Prosthet Dent2012，108，3：	1
7	Macrophage-dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival 显示文摘	Cirillo DM Valdivia RH Monack DM	1998	Mol Microbiol1998，30，1：	1
8	Circularly polarized wave propagation in magnetofluid dynamics for relativistic electron positron plasmas显示文摘	Asenjo F A Mufiz V Valdivia J A	2009	Phys Plasmas2009，16，12：	1
9	Biological nitrogen removal with three different SBBR显示文摘	Valdivia A González-Martínez S Wilderer P A	2007	Water Science & Technology2007，55，7：	1
10	Technique and com-plications of percutaneous nephroscopy: experience with 557 pa-tients in the supine position显示文摘	Valdivia Ufia JG Valle J Lopez JA et a1	1998	J Urol1998，160，61：	1
11	FACS-optimized mutants of the green fluorescent protein显示文摘	Cormack B P Valdivia R Fallow S	1996	Gene1996，173，：	1
12	Use of the Trendelenburg posi- tion as the resuscitation position:to T or not to T? 显示文摘	Bridges N Jarquin - Valdivia AA	2005	Am J Crit Care2005，14，5：	1
13	Longitudinal clinical evaluation of post systems:a literature review显示文摘	Soares CJ Valdivia AD da Silva GR	2012	Braz Dent J2012，23，2：	1
14	Sarcoplasmic reticulum Ca2+ and heart failure : roles of diastolic leak and Ca2+ transport显示文摘	BERS D M EISNER D A VALDIVIA H H	2003	Circ Res2003，93，6：	1
15	Comminuted talar neck fractures: a mechanical comparison of fixation techniques显示文摘	ATTIAH M SANDERS DW VALDIVIA G	2007	J Orthop Trauma2007，21，1：	1
16	FACS-optimized multants of the green fluorescent protein(GFP)显示文摘	Cormack BP Valdivia RH Falkow S		0，，1：	1
17	Effect of combined physico-chemical preservatives on enterocin AS-48 activity against the enterotoxigenic Staphylococcus aureus CECT 976 sWain显示文摘	Ananou S Valdivia E	2004	Journal of Applied Microbiology2004，97，：	1
18	Technique and compli- cations of pereutaneous nephroseopy experience with 557 pa- tients in the supine position显示文摘	Valdivia JG Valle GJ Lopez J A	1998	J Urol1998，160，61：	1
19	Regional stress influence on the opening direction of crater amphitheaters in Southeast Asian volcanoes显示文摘	LAGMAY A M F VALDIVIA W	2006	Journal of Volcanology and Geothermal Research2006，158，12：	1
20	cADP-ribose activates reconstituted ryanodine receptors from coronary arterial smooth muscle显示文摘	Li PL Tang WX Valdivia HH	2001	Am J Physiol Heart Circ Physiol2001，280，1：	1

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