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| 1 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 2 | Intravenous morphine titration显示文摘 | AUBRUN F VALADE N RIOU B | 2004 | Ann Fr Anesth Reanim2004，23，： | 1 |
| 3 | Response of Jack pine chemimechanical pulp to PFI mill beating显示文摘 | Law K N Valade J L Gonzalwa E | 1999 | Appita J1999，52，4： | 1 |
| 4 | Intravenous morphine titration 显示文摘 | Aubrun F Valade N Riou B | 2004 | Ann Fr Anesth Reanim2004，23，10： | 1 |
| 5 | Does sciatic parasacral injection spread to the obturator nerve? an anatomic study 显示文摘 | Valade N Ripart J Nouvellon E | 2008 | Anesth Analg2008，106，2： | 1 |
| 6 | Does sciatic parasaeral injection spread to the obturator nerve? An anatomic study显示文摘 | Valade N Ripart J Nouvellon E | 2008 | Anesth Analg2008，106，2： | 1 |
| 7 | Thromboeytosis after trauma : incidence, aetiology, and clinical significance 显示文摘 | Valade N Decailliot F R6bufat Y | 2005 | Br JAnaesth2005，94，1： | 1 |
| 8 | Thrombocytosis after trauma: Incidence, aetiology, and clinical significance 显示文摘 | Valade N Decailliot F Rebufat Y | 2005 | Br J Anaesth2005，94，1： | 1 |
| 9 | Predictive factors of severe postoperative pain in the postanesthesia care unit显示文摘 | Aubrun F Valade N Coriat P | 2008 | Anesth Analg2008，106，5： | 1 |
| 10 | Thrombocytosis after trauma: incidence, aetiology, and clinical significance 显示文摘 | VALADE N DECAILLIOT F REBUFAT Y | 2005 | British Journal of Anaesthesia2005，94，1： | 1 |
| 11 | Predictive factors of se- vere postoperative pain in the postanesthesia care unit显示文摘 | Aubrun F Valade N Coriat P | 2008 | Anesth Analg2008，106，5： | 1 |
| 12 | Thrombocytosis after trauma:incidence,aetiology,and clinical significance显示文摘 | Valade N Decailliot F Rebufat Y | 2005 | Br J Anaesth2005，94，1： | 1 |
| 13 | Thrombocytosis af- ter trauma: incidence, aetiology, and clinical significance显示文摘 | Valade N Decailliot F R6bufat Y | 2005 | Br J Anaesth2005，94，1： | 1 |
| 14 | Predictive factors of severe postoperative pain in the postanesthesia care unit 显示文摘 | Aubrun F Valade N Coriat P | 2008 | Anesth Analg2008，106，5： | 1 |
| 15 | Thrombocytosis after trauma:incidence, aetiology, and clinical significance 显示文摘 | Valade N Decailliot F Rebufat Y | 2005 | British Journal of Anaesthesia2005，94，1： | 1 |
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