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| 1 | Hepatitis B virus subgenotypes and basal core promoter mutations in Indonesia显示文摘AIM:To identify the distribution of hepatitis B virus (HBV) subgenotype and basal core promoter (BCP) mutations among patients with HBV-associated liver disease in Indonesia.METHODS: Patients with chronic hepatitis (CH, n=61), liver cirrhosis (LC, n=62), and hepatocellular carcinoma (HCC,n=48) were included in this study. HBV subgenotype was identified based on S or preS gene sequence, and mutations in the HBx gene including the overlapping BCP region were examined by direct sequencing.RESULTS: HBV genotype B (subgenotypes B2, B3, B4, B5 and B7) the major genotype in the samples, accounted for 75.4%, 71.0% and 75.0% of CH, LC and HCC patients, respectively, while the genotype C (subgenotypes C1, C2 and C3) was detected in 24.6%, 29.0%, and 25.0% of CH, LC, and HCC patients, respectively. Subgenotypes B3 (84.9%) and C1 (82.2%) were the main subgenotype in HBV genotype B and C, respectively. Serotype adw2 (84.9%) and adrq+ (89.4%) were the most prevalent in HBV genotype B and C, respectively. Double mutation (A1762T/G1764A) in the BCP was significantly higher in LC (59.7%) and HCC (54.2%) than in CH (19.7%), suggesting that this mutation was associated with severity of liver disease. The T1753V was also higher in LC (46.8%), but lower in HCC (22.9%) and CH (18.0%), suggesting that this mutation may be an indicator of cirrhosis.CONCLUSION: HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia. Mutations in BCP, such as A1762T/G1764A and T1753V, might have an association with manifestations of liver disease. | Andi Utama Sigit Purwantomo Marlinang Diarta Siburian Rama Dhenni Rino Alvani Gani Irsan Hasan Andri Sanityoso Upik Anderiani Miskad Fardah Akil Irawan Yusuf Wenny Astuti Achwan Soewignjo Soemohardjo Syafruddin AR Lelosutan Ruswhandi Martamala Benyamin Lukito Unggul Budihusodo Laurentius Adrianus Lesmana Ali Sulaiman Susan Tai | 2009 | World Journal of Gastroenterology2009，15，32： | 4 |
| 2 | Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients显示文摘AIM:To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients.METHODS:Sixty-four patients with chronic hepatitis,65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this study.HBeAg and hepatitis B e antibody (HBeAb) tests were performed using enzyme-linked immunosorbent assay and the mutations were analyzed by sequencing.Viral load was measured by real-time polymerase chain reaction.RESULTS:Of 179 patients,108 (60.3%) were HBeAg(-) and 86 (79.6%) of these HBeAg(-) patients had been seroconverted.The A1896 mutation was not found in HBeAg(+) patients,however,this mutation was detected in 70.7% of HBeAg(-) patients.This mutation was frequently found when HBeAg was not expressed (87.7%),compared to that found in HBeAg seroconverted patients (65.1%).The A1899 mutation was also more prevalent in HBeAg(-) than in HBeAg(+) patients (P=0.004).The T1762/A1764 mutation was frequently found in both HBeAg(+) and HBeAg(-) patients,however,the prevalence of this mutation did not significantly differ among the two groups (P=0.054).In HBeAg(+) patients,the T1762/A1764 mutation was correlated with lower HBV DNA (P < 0.001).The A1899 mutation did not correlate with HBV DNA (P=0.609).In HBeAg(-) patients,the T1762/A1764 mutation alone was not correlated with HBV DNA (P=0.095),however,the presence of either the T1762/A1764 or A1896 mutations was associated with increased HBV DNA (P < 0.001).CONCLUSION:The percentage of HBeAg(-) patients is high in Indonesia,and most of the HBeAg(-) patients had been seroconverted.The A1896 mutation was most likely the major cause of HBeAg loss.The T1762/A1764 mutation alone was associated with lower viral loads in HBeAg(+) patients,but not in HBeAg(-) patients. | Andi Utama Marlinang Diarta Siburian Sigit Purwantomo Mariana Destila Bayu Intan Tri Shinta Kurniasih Susan Tai Rino Alvani Gani Laurentius Adrianus Lesmana All Sulaiman Wenny Astuti Achwan Soewignjo Soemohardjo Arnelis Nasrul Zubir Julius Syafruddin AR Lelosutan Benyamin Lukito Tantoro Harmono | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 3 | Hepatitis B virus pre-S2 start codon mutations in Indonesian liver disease patients显示文摘AIM: To identify the prevalence of pre-S2 start codon mutations and to assess their association with liver disease progression. METHODS: The mutations were identified by direct sequencing from 73 asymptomatic carriers, 66 chronic hepatitis (CH), 66 liver cirrhosis (LC) and 63 hepatocellular carcinoma (HCC) patients. Statistical significances were determined using Fisher's exact test, χ 2 test, and t -test analyses whenever appropriate. Pre-S mutation as a risk factor for advanced liver disease was estimated by unconditional logistic regression model adjusted with age, sex, and hepatitis B e antigen (HBeAg). P < 0.05 was considered significant. RESULTS: Mutation of the hepatitis B virus (HBV) pre-S2 start codon was found in 59 samples from 268 subjects (22.0%), with higher prevalence in patients with cirrhosis 27/66 (40.9%) followed by HCC 18/63 (28.6%), chronic hepatitis 12/66 (18.2%) and asymptomatic carriers 2/73 (2.7%) (P < 0.001). Logistic regression analysis showed that pre-S2 start codon mutation was an independent factor for progressive liver disease. Other mutations, at T130, Q132, and A138, were also associated with LC and HCC, although this was not statistically significant when adjusted for age, sex, and HBeAg. The prevalence of pre-S2 start codon mutation was higher in HBV/B than in HBV/C (23.0% vs 19.1%), whilst the prevalence of T130, Q132, and A138 mutation was higher in HBV/C than in HBV/B. The prevalence of pre-S2 start codon mutation was higher in LC (38.9%) and HCC (40.0%) than CH (5.6%) in HBeAg(+) group, but it was similar between CH, LC and HCC in HBeAg(-) group. CONCLUSION: Pre-S2 start codon mutation was higher in Indonesian patients compared to other Asian countries, and its prevalence was associated with advanced liver disease, particularly in HBeAg(+) patients. | Andi Utama Marlinang Diarta Siburian Ismail Fanany Mariana Destila Bayu Intan Rama Dhenni Tri Shinta Kurniasih Syafruddin AR Lelosutan Wenny Astuti Achwan Nasrul Zubir Arnelis Benyamin Lukito Irawan Yusuf Laurentius Adrianus Lesmana Ali Sulaiman | 2012 | World Journal of Gastroenterology2012，18，38： | 3 |
| 4 | Numerical Investigation of Contra Rotating Vertical-Axis Tidal-Current Turbine显示文摘In this study,the performance of a contra rotating vertical-axis tidal-current turbine was investigated.The incompressible unsteady Reynolds-averagedNavier-Stokes(U-RANS)equations were solved via two-dimensional(2D)numerical simulation using ANSYS Fluent computational fluid dynamics(CFD)code.An algorithm known as SIMPLE from the CFD code was used to calculate the pressure-velocity coupling and second-order finite-volume discretization for all the transport equations.The base turbine model was validated using the available experimental data.Three given scenarios for the contra rotating turbine were modeled.The contra rotating turbine performs better in a low tip speed ratio(TSR)than in a high TSR operation.In a high TSR operation,the contra rotating turbine inefficiently operates,surviving to rotate in the chaotic flow distribution.Thus,it is recommended to use contra rotating turbine as a part of new design to increase the performance of a vertical-axis tidal-current turbine with a lower TSR. | Dendy Satrio I Ketut Aria Pria Utama Mukhtasor | 2018 | Journal of Marine Science and Application2018，17，2： | 2 |
| 5 | 基于磁诱导微柱阵列可无线充电的超灵敏柔性传感器显示文摘为实现在宽感知范围内对微小压力变化的精确测量,提高柔性压力传感器的灵敏度和工作范围显得尤为迫切.然而,由于柔性传感器所使用的软基质材料的固有局限,实现超过100 kPa工作范围同时维持1000 kPa^(-1)以上的灵敏度仍然是一项挑战.本文报道了一种磁诱导的多孔弹性体(PDMS),分别以微柱阵列(MPA)作为传感材料和具有编织结构的导电镍作为电极.由于MPA的独特结构和电极的织构形态,所开发的传感器具有10,268 kPa^(-1)(0.6–170 kPa范围内)的超高灵敏度,高达500 kPa的工作范围,并具有长期耐用性.并实现了最小0.25 Pa的检测压力和3 ms的响应时间.此外,将柔性传感器、柔性超级电容器和感应线圈进行一体化集成,实现了对传感器的无线能量传输,并在低压至高压范围内对传感实际应用能力进行了测试.本项研究工作将具有微结构的高性能传感器与无线充电系统结合在一起,为开发下一代柔性电子产品提供了一种新颖的方法. | 高立波 韩英 James Utama Surjadi 曹可 周文钊 徐洪成 胡新康 王明智 樊康旗 王月皎 王卫东 Horacio DEspinosa | 2021 | Science China Materials2021，64，8： | 2 |
| 6 | Effect of Nuclear Ae- tin on Endothelial Nitric Oxide Synthase Expression 显示文摘 | Ou H Shen YH Utama B | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 7 | Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region显示文摘 | Shimizu H Utama A Onnimala N | 2004 | Pediatr Int2004，46，2： | 1 |
| 8 | Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region显示文摘 | Shimizu H Utama A Onnirnala N | 2004 | Pediatr Int2004，46，： | 1 |
| 9 | Phased processing of facial emotion:an ERP study显示文摘 | Utama NP Takemoto A Koike Y | 2009 | Neurosci Res2009，64，1： | 1 |
| 10 | Molecular epidemiology of en-terovirus 7 1 infection in the Western Paeifie Re,on显示文摘 | Shimizu H Utama A Onnimala N | 2004 | Pediatr Int2004，46，2： | 1 |
| 11 | Molecular epidemiology of enterovirus 71infection in the Western Pacific Region显示文摘 | Shimizu H Utama A Onnimala N | 2004 | Pediatr Int2004，46，： | 1 |
| 12 | Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epi- demics in Malaysia, Japan and Taiwma in 1997-1998 显示文摘 | SHIM1ZU H UTAMA A YOSHII K | 1999 | Jpn J Infect Dis1999，52，1： | 1 |
| 13 | Vertically aligned cadmium chalcogenide nanowire arrays on muscovite mica: a demonstration of epitaxial growth strategy显示文摘 | Utama M I B Peng Z Chen R Peng B Xu X Dong Y Wong L M Wang S Sun H Xiong Q | 2011 | Nano Let- ters2011，11，8： | 1 |
| 14 | Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells显示文摘 | Gan Y Shen YH Utama B | 2006 | Biochem Biophys Res Commun2006，340，3： | 1 |
| 15 | Factors influencing bone mineral density in ARV-naive patients at Sanglah Hospital,Bali显示文摘 | Masyeni S Utama S Somia A | 2013 | Acta Med Indones2013，45，3： | 1 |
| 16 | Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region 显示文摘 | Shimizu H Utama A Onnimala N | 2004 | Pediatr Int2004，46，2： | 1 |
| 17 | Molecular epidemiology of enterovirus71 infection in the Western Pacific Region显示文摘 | Shinizu H Utama A Onnimala N | 2004 | Pediatr Int2004，46，2： | 1 |
| 18 | Human prolactin receptorsare insensitive to mouse prolactin:implications for xenotransplant mod-eling of human breast cancer in mice显示文摘 | Utama FE LeBaron MJ Neilson LM | 2006 | Endocrinol2006，188，3： | 1 |
| 19 | Human cytomegalovirus inhibits Akt-mediated eNOS activation through upregulating PTEN (phesphatase and tensin homolog deleted on chromosome 10)显示文摘 | Shen Y H Zhang L Utama B | 2006 | Cardiovaac Res2006，69，2： | 1 |
| 20 | Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region 显示文摘 | Shimizu H Utama A Onnimala N | 2004 | Pediatr Int2004，46，2： | 1 |
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