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| 1 | 石杉碱甲对重度抑郁症患者认知功能障碍的治疗:一项随机对照试验的系统综述(英文)显示文摘背景:乙酰胆碱酯酶(Acetylcholinesterase,AChE)抑制剂在重性抑郁障碍(Major Depressive Disorder,MDD)的动物模型和人类患者中已被证实可以有效地治疗认知障碍。石杉碱甲(Huperzine A,HupA)是一种来自于被称为蛇足石杉(Huperzineserrata)的石松属传统中医药,是一种强有力的AChE抑制剂,已被用于抑郁症的辅助治疗,但有尚无关石杉碱甲对MDD的强化治疗作用的meta分析。目标:对有关石杉碱甲强化治疗抑郁症的随机对照试验进行系统综述和meta分析,评估其疗效及安全性。方法:两位评估者独立检索9个英文和中文数据库,选择符合预先确定的纳入标准的相关研究,提取有关疗效和安全性的数据,并进行质量评估和数据拟合合成。结果:纳入了三项中国低质量的随机对照试验(总共n=238),这些试验比较了单用抗抑郁药治疗抑郁症与抗抑郁药和石杉碱甲的联合治疗,试验中的被试从16岁到60岁。研究中石杉碱甲辅助抗抑郁药治疗的平均时间仅为6.7周。这三项研究都是公开标签未使用盲法,所以他们的总体质量评定为差。总体样本的Meta分析发现两组抑郁症状的改善没有显著性差异(差异加权差为-1.90,95%CI可信区间为-4.23至0.44,p=0.11)。然而,石杉碱甲辅助治疗组比单用抗抑郁药治疗组在认知功能和生活质量方面有显著改善(如威斯康星卡片分类测验、韦氏记忆量表修订的评估)。组间药物不良反应的发生率无显著性差异。结论:有关在接受抗抑郁药的MDD患者使用HupA辅助治疗的疗效和安全性的可获取数据不足,难以得出有关其疗效和安全性的明确结论。汇集国内3项低质量的RCT数据没有发现采用辅助使用HupA治疗抑郁症状的优势,但辅助使用HupA与更快改善经常伴随MDD出现的认知症状相关。 | 郑伟 向应强 Ungvari GS Chiu F.K.H Ng H.C 王颖 项玉涛 | 2016 | 上海精神医学2016，28，2： | 4 |
| 2 | Health-related quality oflife in community-dwelling men with pneumoconiosis 显示文摘 | Tang WK Lum CM Ungvari GS | 2006 | Respiration2006，73，2： | 1 |
| 3 | Efficacy of electroconvulaive therapy in treatment-resistant schizophrenia:a prospective open trial显示文摘 | Tang WK Ungvari Gs | 2003 | Prog Neur-opsychopharmacol Biol Psychiatry2003，27，： | 1 |
| 4 | Efficacy of electroconvulsive therapyin treatment-resistant schizophrenia: a prospective open trial 显示文摘 | Tang WK Ungvari GS | 2003 | Prog Neuropsychopharmacol Biol Psychiatry2003，27，3： | 1 |
| 5 | Performance of schizophrenia patients on time-,event-,and activity-based prospective memory tasks显示文摘 | Shum D Ungvari GS Tang WK | 2004 | Schizophr Bull2004，30，4： | 1 |
| 6 | Dopamine D3 receptor gene and tardive dyskinesia in Chinese schizophrenic patients 显示文摘 | Carcia - Barcelo MM Lam LCMM Ungvari GS | 2001 | Neural Transm2001，108，2： | 1 |
| 7 | Performance ofschizophrenia patients on time-, event-, and activity-based prospective memory tasks 显示文摘 | Shum D Ungvari GS Tang WK | 2004 | Schizophrenia Bulletin2004，30，4： | 1 |
| 8 | Performance of schizophrenia patients on time, event, and activity-based prospective memory tasks 显示文摘 | Shum D Ungvari GS Tang WK | 2004 | Schizophr Bult2004，30，： | 1 |
| 9 | Schizophrenia and prospective memory:A new direction for clinical practice and research?显示文摘 | Shum D Leung JP Ungvari GS | 2001 | Hong Kong J Psychiatry2001，11，2： | 1 |
| 10 | Prospective memory and its correlates and predictors in schizophrenia:an extension of previous findings显示文摘 | Ungvari GS Xiang YT Tang WK | 2008 | Arch Clin Neuropsychol2008，23，5： | 1 |
| 11 | Quality of life and mental health in Chinese culture显示文摘 | Xiang YT Chiu HF Ungvari GS | 2010 | Curr Opin Psychiatry2010，23，1： | 1 |
| 12 | Heahh-related quality of life in community-dwelling men with pneumoconiosis 显示文摘 | Tang WK Lure CM Ungvari GS | 2006 | Respiration2006，73，： | 1 |
| 13 | Schizophrenia and prospectivememory :a new direction for clinical practice and research显示文摘 | Shum D Leung JP Ungvari GS | 2001 | HongKong J Psychiatry2001，11，2： | 1 |
| 14 | Undiagnosed bipolar disor- der in patients treated for major depression in China显示文摘 | Hu C Xiang YT Ungvari GS | 2012 | J Affect Disord2012，140，2： | 1 |
| 15 | Performance of schizophre- nia patients on time-, event-, and activity-based prospective memory tasks 显示文摘 | Shum D Ungvari GS Tang WK | 2004 | Sehizophr Bull2004，30，4： | 1 |
| 16 | Performance of schizo- phrenia patients on time-, event-, and activity-based prospec- tive memory tasks 显示文摘 | Shum D Ungvari GS Tang WK | 2004 | Schizophr Bull2004，30，4： | 1 |
| 17 | Detecting depression in Chinese stroke patients:a pilot study comparing four screening instruments显示文摘 | Tang WK Ungvari GS Chiu HF | 2004 | Int J Psychiatry Med2004，34，2： | 1 |
| 18 | Detecting depression in Chinese stroke patients:a pilot study comparing four screening instruments显示文摘 | Tang WK Ungvari GS Chiu HF | 2004 | Int J Psychiatry Med2004，34，： | 1 |
| 19 | Prospective memory and its correlates and predictors in schizophrenia: an extension of previ- ous findings 显示文摘 | Ungvari GS Xiang YT Tang WK | 2008 | Arch Clin Neuropsychol2008，23，5： | 1 |
| 20 | Detecting depres- sion in Chinese stroke patients: a pilot study comparing four screening instruments显示文摘 | Tang WK Ungvari GS Chiu HF | 2004 | Int J Psychiatry Med2004，34，2： | 1 |
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