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| 1 | Endo-β-1,4-glucanases impact plant cell wall development by influencing cellulose crystallization显示文摘Cell walls are vital to the normal growth and development of plants as they protect the protoplast and provide rigidity to the stem. Here, two poplar and Arabidopsis orthologous endoglucanases, which have been proposed to play a role in secondary cell wall development, were examined. The class B endoglucanases, Pt GH9B5 and At GH9B5, are secreted enzymes that have a predicted glycosylphosphatidylinositol anchor, while the class C endoglucanases, Pt GH9C2 and At GH9C2, are also predicted to be secreted but instead contain a carbohydrate-binding module.The poplar endoglucanases were expressed in Arabidopsis using both a 35 S promoter and the Arabidopsis secondary cell wall-specific Ces A8 promoter. Additionally, Arabidopsis t-DNA insertion lines and an RNAiconstruct was created to downregulate At GH9C2 in Arabidopsis. All of the plant lines were examined for changes in cell morphology and patterning, growth and development, cell wall crystallinity, micro fibril angle, and proportion of cell wall carbohydrates. Misregulation of Pt GH9B5/At GH9B5 resulted in changes in xylose content, while misregulation of Pt GH9C2/At GH9C2 resulted in changes in crystallinity, which was inversely correlated with changes in plant height and rosette diameter. Together, these results suggest that these endoglucanases affect secondary cell wall development by contributing to the cell wall crystallization process. | Magdalena Glass Sarah Barkwill Faride Unda Shawn D.Mansfield | 2015 | Journal of Integrative Plant Biology2015，57，4： | 6 |
| 2 | Levels and activities of von Willebrand factor and metalloproteinase with thrombospondin type-1 motif, number 13 in inflammatory bowel diseases显示文摘AIM To evaluate the levels of von Willebrand factor(VWF) and metalloproteinase with thrombospondin type-1 motif, number 13(ADAMTS13) in inflammatory bowel disease(IBD) and correlate them with the disease activity.METHODS Consecutive patients with IBD aged 18 years or older were enrolled in the study. Forty-seven patients with ulcerative colitis(UC), 38 with Crohn's disease(CD), and 50 healthy controls were included. The white blood cell count, haematocrit, platelet count, fibrinogen, partial activated thromboplastin time, C-reactive protein, albumin, VWF antigen level(VWF:Ag), VWF ristocetin cofactor activity(VWF:RCo), VWF collagen-binding activity(VWF:CB), and ADAMTS13 antigen level(ADAMTS13:Ag) and activity(ADAMTS13act) were measured. The following ratios were assessed: V W F : R C o/V W F : A g, V W F : C B/V W F : A g, V W F : A g/ADAMTS13 act, and ADAMTS13act/ADAMTS13:Ag. RESULTS Compared to controls, the odds ratio(OR) of an elevated VWF: Ag > 150% was 8.7(95%CI: 2.7-28.1) in the UC group and 16.2(95%CI: 4.8-54.0) in the CD group. VWF:CB was lower in UC patients, and active CD was associated with a higher VWF: RCo(+38%). The ORs of VWF:CB/VWF:Ag < 0.7(a marker of acquired von Willebrand syndrome) in the UC and CD groups were 11.9(95%CI: 4.4-32.4) and 13.3(95%CI: 4.6-38.1), respectively. Active UC was associated with lower ADAMTS13:Ag(-23%) and ADAMTS13act(-20%) compared to UC in remission. Patients with active CD had a 15% lower ADAMTS13 act than controls. The activity of UC, but not that of CD, was inversely correlated with ADAMTS13:Ag(r =-0.76) and ADAMTS13act(r =-0.81). CONCLUSION Complex VWF-ADAMTS13-mediated mechanisms disturb haemostasis in IBD. A reduced WVF:CB is a risk factor for bleeding, while a lower ADAMTS13 level combined with an elevated VWF:Ag could predispose one to thrombosis. | Dorota Cibor Danuta Owczarek Saulius Butenas Kinga Salapa Tomasz Mach Anetta Undas | 2017 | World Journal of Gastroenterology2017，23，26： | 3 |
| 3 | 动物流行性溃疡综合症(EUS)的调查及启示显示文摘2009年,对动物流行性溃疡综合症在纳米比亚的流行情况进行了调查,比较并综合了2007年、2008年的数据。结果表明纳米比亚不是EUS的发源地;该病在纳米比亚的流行区域主要为赞比西河沿岸以及和安哥拉、赞比亚相邻的Kavango和Caprivi两个省;流行时间为6月~11月;幼鱼发病率高于成鱼。初步分析该病的发生与异地传播、高密度养殖、管理不善有关;提醒国内相关部门在进出口时高度重视;同时广大养殖工作者也要酌情采取预防措施。 | 肖秀娥 Alushe Hitula Unda Tjihuiko | 2010 | 中国动物检疫2010，27，6： | 2 |
| 4 | Homocysteine inhibits inactivation of factor Va by activated protein C显示文摘 | Undas A Williams EB Butenas S | 2001 | Biol Chem2001，276，6： | 1 |
| 5 | Comparison of different culture media and growth conditions for recogrdtion of Arcanobacterium hacmolyticum 显示文摘 | Garcia-de-la-Fuente C Campo-Esquisabel AB Unda F | 2008 | Diagn Microbiol Infect Dis2008，61，2： | 1 |
| 6 | Simvastatin depressesblood clotting by inhibiting activation of prothrombin,factor V, and factor X II and by enhancing factor Va inactivation 显示文摘 | Undas A Brummel K E Musial J | 2001 | Circulation2001，，103： | 1 |
| 7 | Platlet glycoprotein Ⅲa polymorphism, aspirin,and thrombin generation显示文摘 | Undas A Sanak M Musial J Szczeklik | 1999 | Lancet1999，353，： | 1 |
| 8 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial J Undas A Gajewski P | 2001 | Int J Cardiol2001，77，23： | 1 |
| 9 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial J Undas A Gajewski P | 2001 | Int J Cardiol2001，77，： | 1 |
| 10 | Treatment with simvastatin and low- dose aspirin depresses thrombin generation in patients with coronary heart disease and borderline -high cholesterol levels 显示文摘 | Undas R | 2001 | Thromb Haemost2001，85，： | 1 |
| 11 | Simvastation diprsses blood clotting activation of prothrombin, factor Ⅴ, and factor Ⅶ and by enhancing factor Va in activation 显示文摘 | Undas A Brummell KE Musial J | 2001 | Circulation2001，103，18： | 1 |
| 12 | Anticoagulant effects of statins and their clinical implications显示文摘 | Undas A Brurnmel - Ziedins KE Mann KG | 2014 | Thromb Haem- ost2014，111，3： | 1 |
| 13 | Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, and factor Ⅻ and by enhancing factor Va inactivation显示文摘 | Brummel KE Musial J | 2001 | Circulation2001，103，： | 1 |
| 14 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia 显示文摘 | Musial J Undas A Gajewski P | 2001 | Int J Carttiol2001，77，： | 1 |
| 15 | Simvastatin depresses blood clotting by inhibiting acti-vation of prothrombin, factor V, and factor XIII and by enhancing factor Vainactivation显示文摘 | Undas A Brummel KE Musial J | 2001 | Circulation2001，103，18： | 1 |
| 16 | The effect of chronic kidney disease on fibrin clot properties in patients with acute coronary syndrome显示文摘 | Undas A Nycz K Pastuszczak M | 2010 | Blood Coagul Fibrinolysis2010，21，6： | 1 |
| 17 | Effects of polyunsaturated omega-3 fatty acids on responsiveness to dual antiplatelet therapy in patients undergoing percutaneous coronary intervention:the OMEGA-PCI (OMEGA-3 fatty acids after PCI to modify responsiveness to dual antiplatelet therapy) study显示文摘 | Gajos G Rostoff P Undas A | 2010 | J Am Coll Cardiol2010，55，16： | 1 |
| 18 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia显示文摘 | Musial Undas A Gajewski P | 2001 | Int J Cardiol2001，77，： | 1 |
| 19 | Qualitative multicriteria methods for fuzzy evaluation problems:An illustration of economic-ecological evaluation 显示文摘 | UNDA G NIJKAMP P RIETVELD P | 1995 | European Journal of Operational Research1995，82，： | 1 |
| 20 | Simvastation depresses blood clotting activation of prothrombin,factor V,and factor Ⅻ and by enhancing factor Va in activation显示文摘 | Undas A Brummel KE Musial J | | 0，，： | 1 |
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