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	题名	作者	年代	出处	被引量
1	Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model显示文摘AIM: To compare the effect of transarterial chemoembolization(TACE) plus GRGDSP(Gly-Arg-Gly-Asp-SerPro, integrin-inhibitor) loaded nanoparticles with TACE alone or TACE + GRGDSP in a rat model of liver tumor. METHODS: Morris hepatoma 3924 A tumors were implanted in the livers of 30 ACI rats. The ACI rats were divided randomly into three groups(10 animals each). Tumor volume before treatment(V1) was examined by magnetic resonance imaging(MRI), and then, after laparotomy and placement of a PE-10 catheter into the hepatic artery, the following interventional protocols were performed: TACE(mitomycin C + lipiodol + degradable starch microspheres) + GRGDSP loaded nanoparticles for group A; TACE + GRGDSP for group B(control group 1); TACE alone for group C(control group 2). Tumor volume(V2) was assessed by MRI and the mean ratio of the post-treatment to pretreatment tumor volumes(V2/V1) was calculated. Immunohistochemical analysis was performed to assess the quantification of matrix metalloprotein 9(MMP-9) and vascular endothelial growth factor(VEGF) positive tumor cells in each treatment group.RESULTS: The mean tumor growth ratios(V2/V1) were 1.3649 ± 0.1194 in group A, 2.0770 ± 0.1595 in group B, and 3.2148 ± 0.1075 in group C. Compared with groups B and C, group A showed a significant reduction in tumor volume. Lower expression of MMP-9 and VEGF in hepatocellular carcinoma was observed in group A than in groups B and C. The angiogenesis of tumor was evaluated using anti-VEGF antibodies, and the metastasis of tumor was assessed using antiMMP-9 antibody. MMP-9 and VEGF were expressed in all specimens. The immunoexpression of these proteins was confirmed by the presence of red cytoplasmic staining in tumor cells. Lower expression of MMP-9 and VEGF in hepatocellular carcinoma was observed in group A than in groups B and C.CONCLUSION: Transarterial administration of integrin inhibitor loaded nanoparticles combined with TACE evidently retards tumor growth and intrahepatic metastases compared with TACE alone or TACE plus integrin inhibitor in an animal model of hepatocellular carcinoma.	Jun Qian Elsie Oppermann Andreas Tran Ulli Imlau Kun Qian Thomas Josef Vogl	2016	World Journal of Gastroenterology2016，22，21：	2
2	New Dimensions of Outsourcing:A Combination of Transaction Cost Economics and the Core Competencies Concept 显示文摘	Ulli Arnold	2000	European Journal of Purchasing & Supply Management2000，6，：	1
3	New dimensions of outsourcing: a combination of transaction cost economics and the core competencies concept 显示文摘	ARNOLD ULLI	2003	European Journal of Purchasing & Supply Management2003，，6：	1
4	Global Sourcing-An Indispensable Element in Worldwide Competition 显示文摘	Amold Ulli	1989	Management International Review Fourth Quarter1989，29，4：	1
5	New dimensions of outsourcing:A combination of transaction cost economics and the core competencies concept显示文摘	Arnold Ulli	2000	European Journal of Purchasing & Supply Management2000，6，：	1
6	New Dimensions of Outsourcing:a Combination of Transaction Cost Economics and the Core Competencies Concept显示文摘	ULLI ARNOLD	2000	European Journal of Purchasing & Supply Management2000，，6：	1
7	Collective Monte Carlo Updating for Spin Systems显示文摘	Ulli Wolff	1989	Physical Review Letters1989，62，4：	1
8	New Dimensions of Outsourcing:A Combination of Transaction Cost Economics and the Core Competencies Concept显示文摘	Arnold Ulli	2000	European Journal of Purchasing & Supply Management2000，6，：	1
9	New Dimensions of Outsourcing: A Combination of Transaction Cost Economics and the Core Competencies Concept显示文摘	Arnold Ulli	2000	European Journal of Purchasing &Supply Management2000，，6：	1
10	New dimensions of outsourcing: a combination of transaction cost economics and the core competencies concept 显示文摘	Ulli Arnold	2000	European Journal of Purchasing & supply Management2000，，：	1
11	Fluid selection for the organic Rankine cycle (ORC) in biomass power and heat plants显示文摘	Ulli Drescher Dieter Bmggemann	2007	Applied Thermal Engineering2007，27，1：	1
12	New Dimensions of Outsourcing:a Combination of Transaction Cost Economics and the Core Competencies Concept显示文摘		2000	European Journal of Purchasing & Supply Management2000，，6：	1
13	On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids显示文摘	HAFEZ I M MAURER N C ULLIS P R	2001	Gene Ther2001，8，：	1
14	Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction 显示文摘	Ullis K B Faloona F A	1987	Methods Enzymoi1987，155，4：	1
15	Fluid selection forthe Organic Rankine Cycle in biomass power and heatplants 显示文摘	Ulli Drescher Dieter Briiggemann	2007	Applied Thermal Engineering2007，27，1：	1
16	Solid phase extraction of acrolein 2,4- dinitrophenylhydrazone for HPLC analysis显示文摘	Oltmann P Coppock R W Ullie L E	1988	Water Research1988，22，9：	1
17	Fluid Selection for the Or- ganic Rankine Cycle (ORC) in Biomass Power and Heat Plan-ts显示文摘	Ulli Drescher Dieter Bruggemann	2007	Applied Thermal Engineering2007，27，1：	1
18	New dimensions of outsourcing :a combination of transaction cost economics and the core competencies concept显示文摘	Ulli Arnold	2000	European Journal of Purchasing-Supply Management2000，6，：	1
19	New dimensions of outsourcing:a combination of transaction cost economics and the core competencies concept显示文摘	Ulli Arnold	2000	European Journal of Purchasing & Suly Management2000，，6：	1
20	New Dimensions of Outsourcing : A Combination ofTransaction Cost Economics and the Core Competencies Concept显示文摘	Ulli Aronld	2000	Europeon Journal of Purchasing & Supply Management2000，，6：	1

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