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| 1 | CYP1A1 , GSTM1 , GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men显示文摘AIM: To investigate the role of functional genetic poly-morphisms of metabolic enzymes of tobacco carcinogens in the development of colorectal adenomas. METHODS: The study subjects were 455 patients with colorectal adenomas and 1052 controls with no polyps who underwent total colonoscopy in a preretirement health examination at two Self Defense Forces hospitals. The genetic polymorphisms studied wereCYP1A1*2A (rs 4646903), CYP1A1*2C (rs 1048943), GSTM1 (null or non-null genotype), GSTT1 (null or non-null genotype) and NQO1 C609T (rs 1800566). Genotypes were determined by the polymerase chain reaction (PCR)-restriction fragment length polymorphism or PCR method using genomic DNA extracted from the buffy coat. Cigarette smoking and other life-style factors were ascertained by a self-administered questionnaire. The associations of the polymorphisms with colorectal adenomas were examined by means of OR and 95%CI, which were derived from logistic regression analysis. Statistical adjustment was made for smoking, alcohol use, body mass index and other factors. The gene-gene interaction and effect modification of smoking were evaluated by the likelihood ratio test. RESULTS: None of the five polymorphisms showed a significant association with colorectal adenomas, nor was the combination of GSTM1 and GSTT1 . A borderline significant interaction was observed for the combination of CYP1A1*2C and NQO1 (P = 0.051). The OR associated with CYP1A1*2C was significantly lower than unity among individuals with the NQO1 609CC genotype. The adjusted OR for the combination of the CYP1A1*2C allele and NQO1 609CC genotype was 0.61 (95%CI: 0.42-0.91). Although the interaction was not statistically significant (P = 0.24), the OR for individuals carrying the CYP1A1*2C allele and GSTT1 null genotype decreased significantly compared with those who had neither CYP1A1*2C allele nor GSTT1 null genotype (adjusted OR: 0.69, 95%CI: 0.49-0.97). Smoking did not modify the associations of the individual polymorphisms with colorectal adenomas. There was no measurable effect modification of smoking even regarding the combination of the genetic polymorphisms of the phaseⅠ and phase Ⅱ enzymes. CONCLUSION: Combination of the CYP1A1*2C and NQO1 609CC genotypes was associated with a decreased risk of colorectal adenomas regardless of smoking status. | Tadamichi Hamachi Osamu Tajima Kousaku Uezono Shinji Tabata Hiroshi Abe Keizo Ohnaka Suminori Kono | 2013 | World Journal of Gastroenterology2013，19，25： | 3 |
| 2 | Adrenomedullinsensitive receptors are preferentially expressed in cultured rat mesangial cells显示文摘 | Osajima A Uezono Y Tamura M | 1996 | Eur J Pharmacol1996，315，3： | 1 |
| 3 | Glucocorticoids prolong rat sciatic never blocked in vivo from bupivacaine microspheres显示文摘 | CASTILLO J CURLEY J UEZONO M | 1996 | Anesthesiology1996，85，5： | 1 |
| 4 | L-deprenyl prevents the cell hypoxia induced by dopaminergic neurotoxins, MPP+ , and beta-carbolinium: a microdialysis study in rats 显示文摘 | Senda T Uezono T | 2001 | Neurosci Lett2001，302，： | 1 |
| 5 | Morita S:Ermergence agitation after sevoflurane versus propofol in pediatric patients显示文摘 | Uezono S Goto T Terui K | | 0，，03： | 1 |
| 6 | Emergence agitation after sevoflurane versus propofol in pediatric patients显示文摘 | Uezono S Goto T Terui K | 2000 | Anesth Analg2000，91，3： | 1 |
| 7 | A retrospective survey of adversematernal and neonatal outcomes for parturients with congenital heartdisease 显示文摘 | Hidano G Uezono S Terui K | 2011 | International Journal of Obstetric Anesthesia2011，20，3： | 1 |
| 8 | Effect of the amount of nitrogen application on occurrence of white-back kernels during ripening of rice (Oryza Sativa) under high-temperature conditions显示文摘 | Wakamatsu K Sasaki O Uezono I | 2008 | Japanese Journal of Crop Science(Japan)2008，77，4： | 1 |
| 9 | The blood-gas partition coefficient of xenon may be lower than generally accepted显示文摘 | Goto T Suwa K Uezono S | 1998 | British J Anaesthesia1998，80，： | 1 |
| 10 | Emergence agitation after sevoflurane versus propofol in pediatric patients显示文摘 | Uezono S Goto T Terui K | | 0，，03： | 1 |
| 11 | A retrospective survey of adverse maternal and neonatal outcomes for parturients with congenital heart disease显示文摘 | G. Hidano S. Uezono K. Terui | 2011 | International Journal of Obstetric Anesthesia2011，，3： | 1 |
| 12 | Conventional and high-yield synthesis of DTPA conjugated peptides: application of a monoreactive DTPA to DTPA-D-Phe1-octreotide synthesis显示文摘 | Arano Y Akizawa H Uezono T | 1997 | Bioconjugate Chem1997，8，3： | 1 |
| 13 | The inhibitory effects of ketamine and pentobarbital on substance p receptors expressed in xenopus oocytes显示文摘 | OKAMOTO T MINSMI K UEZONO Y | 2003 | Anesth Analg2003，97，1： | 1 |
| 14 | Emergence agitation after sevoflurane versus propnfol in pediatric patients显示文摘 | Uezono S Goto T Terui K | 2000 | Anesth Analg2000，91，3： | 1 |
| 15 | ATP activates DNA synthesis by acting on P2X receptors in human osteo- blast-like MG-63 cells 显示文摘 | Nakamura E Uezono Y Narusawa K | 2000 | Am J Physiol Cell Physiol2000，279，2： | 1 |
| 16 | Emergence agitation after sevoflurane versus propofnl in pediatric patients显示文摘 | Uezono S Goto T Terui K | 2000 | Anesth Analg2000，91，： | 1 |
| 17 | C-reactive protein and colorectal adenomas:Self Defense Forces Health Study显示文摘 | Otake T Uezono K Takahashi R | 2009 | Cancer Sci2009，100，4： | 1 |
| 18 | Sequential changes in transforming growth factor ( TGF ) - betal concentration in synovial fluid and mRNA expression of TGF-betal receptors in chondrocytes after immobililization of rabbit knees 显示文摘 | Okasaki R Sakai A Uezono Y | 2001 | J Bone Miner Metab2001，19，4： | 1 |
| 19 | Factors affecting outcome of intracerebral hemorrhage in patients undergoing chronic hemodialysis 显示文摘 | Ochiai H Uezono S Kawano H | 2010 | Renal Failure2010，32，8： | 1 |
| 20 | Gq protein-coupled receptors as targets for anesthetics 显示文摘 | MINAMI K UEZONO Y | 2006 | Curr Pharm Des2006，12，15： | 1 |
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