| 2 | 冻融后的完整胚胎与局部损伤的冻融胚胎采用激光辅助孵化技术去除坏死的卵裂球及进行选择后潜在存活能力的比较显示文摘Objective: Partially damaged frozen and thawed embryos are currently considered to have a lower viability than intact ones. This study was undertaken to compare the performance of intact frozen and thawed embryos with that of partially damaged embryos after removal of the necrotic blastomeres. Design: Observational clinical series. Setting: Private hospital. Patient(s): Three hundred twenty-six infertile couples undergoing frozen embryo transfer. Intervention(s): Removal of necrotic blastomeres from frozen-thawed human embryos. Main Outcome Measure(s): Pregnancy and implantations rates. Result(s): Outcomes of frozen embryo transfer cycles in which all embryos were fully intact (group 1) were compared with those in which all embryos have lost 1-2 blastomeres (group 2) or 3-4 blastomeres (group 3). Laser-assisted hatching was performed in all embryos, and necrotic blastomeres were removed from partially damaged embryos on this occasion. Only embryos that resumed mitotic activity after thawing were transferred. Comparable clinical pregnancy rates (PR) (38.7%, 39.6%, and 29.4%), delivery rates (34.4%, 34.0%, and 29.4%), and implantation rates (21.6%, 21.4%, and 17.2%) were obtained in groups 1, 2, and 3, respectively. Conclusion(s): The developmental potential of partially damaged frozen and thawed embryos can be equivalent to fully survived embryos if the necrotic blastomeres are removed from the partially damaged embryos and only those of them that show post-thaw cleavage are selected for transfer. | Rienzi L. Ubaldi F. Iacobelli M. 张剑萍 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，2： | 0 |
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