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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 3 | Midiprep method for isolation of DNA from plant with a high cotent of polypholics显示文摘 | UTA P ZNGO S | 1993 | Nucleic Acid Res1993，21，4： | 1 |
| 4 | Rice phosphate transporters include an evolutionarily divergent gene specifically activated in arbuscular mycorrhizal symbiosis显示文摘 | UTA P SCOTY K CHRISTOPHE R | 2002 | PNAS2002，99，13： | 1 |
| 5 | p27: tumor suppressor and oncogene ...?显示文摘 | Uta Kossatz Nisar P Malek | 2007 | Cell Research2007，17，10： | 1 |
| 6 | Supply chain risk management : outlining an agenda for future research 显示文摘 | UTA J HELEN P MARTIN C | 2003 | International Journal of Logistics : Research and Applications2003，6，4： | 1 |
| 7 | Documented norms and conventions on the Intemet显示文摘 | Uta P PhiUip J | 2002 | Intemational Joumal of Human-Computer Interaction2002，14，2： | 1 |
| 8 | Midiprep method for isolation of DNA from plant with a high cotent of polypholics显示文摘 | Uta P Zngo S | 1993 | Nucleic Acid Res1993，21，4： | 1 |
| 9 | Rice phosphate transporters include an evolutionarily divergent gene specifically activated in arbuscular mycorrhizal symbiosis显示文摘 | Uta P Scott K Christophe R | 2002 | PNAS2002，99，13： | 1 |
| 10 | Structure of molecular tweezer complexes in the solid state: NMR experiments, X-ray investigations, and quantum chemical calculations 显示文摘 | Tomten S Uta P B Frank G K | 2007 | J Am Chem Soc2007，129，： | 1 |
| 11 | Neoadjuvant chemoradiotherapy for esophageal cancer:Impact on extracapsular lymph node involvement显示文摘AIM:To assess the effects of neoadjuvant chemoradiotherapy(CRT) on the presence of extracapsular lymph node involvement(LNI) and its prognostic value in patients with resected esophageal cancer.METHODS:Two hundred and ninety-eight patients with advanced esophageal cancer underwent esophagectomy between 1997 and 2006.One hundred and ninety patients(63.8%) were treated with neoadjuvant CRT prior to resection.A total of 986 metastatic LNs were examined.Survival of the patients was analyzed according to intra-and extra-capsular LNI.RESULTS:Five-year survival rate was 22.5% for the entire patient population.Patients with extracapsular LNI had a 5-year survival rate of 16.7%,which was comparable to the 15.8% in patients with infiltrated nodes of the celiac trunk(pM1lymph).In contrast to patients treated with surgery alone,neoadjuvant therapy resulted in signif icantly(P = 0.001) more patients with pN0/M0(51.6% vs 25.0%).In 17.6% of the patients with surgery alone vs 16.8% with neoadjuvant CRT,extracapsular LNI was detected.Neoadjuvant therapy does not reduce the occurrence of extracapsular LNI.CONCLUSION:Extracapsular LNI is an independent negative prognostic factor not influenced by neoadjuvant CRT.In a revised staging system for esophageal cancer,extracapsular LNI should be considered. | Ralf Metzger Elfriede Bollschweiler Uta Drebber Stefan P Mnig Wolfgang Schrder Hakan Alakus Martin Kocher Stephan E Baldus Arnulf H Hlscher | 2010 | World Journal of Gastroenterology2010，16，16： | 1 |
| 12 | Minipreparation method for isolation of DNA from plant with a high cotent of polyphenolics显示文摘 | Uta P Zngo S | 1993 | Nucleic Acid Res1993，21，4： | 1 |
| 13 | Supply chain risk man- agement:outlining an agenda for future research 显示文摘 | UTA J HELEN P MARTIN C | 2003 | International Journal of Logistics:Research & Applica- tions2003，6，4： | 1 |
| 14 | Rice phosphate transporters include and evolutionary divergent gene specifically activated in arbuacular mycorrhizal symbiosis显示文摘 | Uta P Scott K Christophe R | 2002 | PNAS2002，20，13： | 1 |
| 15 | Formal concept analysis in information science 显示文摘 | Uta P | 2006 | Annual Review of Information Science and Technology2006，40，40： | 1 |
| 16 | Midiperp method for isolation of DNA from plants with a high content of polypholies显示文摘 | UTA P ZNGO S | 1993 | Nucleic Acid Res1993，21，14： | 1 |
| 17 | Rice phosphate transporters include an evolutionarily divergent gene specifically activated in arbuscular mycorrhizal symbiosis显示文摘 | Uta P Scott K Christophe R | 2002 | Proc Natl Acad Sci USA2002，99，13： | 1 |
| 18 | Supply chain risk management:outlining an agenda for future research显示文摘 | UTA J HELEN P MARTIN C | 2003 | International Journal of Logistics:Research and Applications2003，6，4： | 1 |
| 19 | idiprep method for isolation of DNA from plant with a high content of polyphenolics显示文摘 | Uta P Zngo S M | 1993 | Nucleic Acid Res1993，21，4： | 1 |
| 20 | Increased detection of lymphatic vessel invasion by D2-40(podoplanin)in early breast cancer:Possible influence on patient selection for accelerated partial breast irradiation显示文摘 | Manuel D Martin P Uta F | 2010 | Int J Radiation Oncology Biol Phys2010，77，4： | 1 |
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