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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux显示文摘AIM To evaluate the agreement of multichannel intraluminal impedance-p H monitoring(MII-p HM) and gastroesophageal reflux scintigraphy(GES) for the diagnosis of gastroesophageal reflux disease. METHODS Seventy-five consecutive patients with suspectedgastroesophageal reflux disease(GERD) underwent 24-h combined MII-p HM recording and one hour radionuclide scintigraphy during the course of the MIIpH M study. Catheters with 6 impedance channels and 1 p H sensor were placed transnasally. Impedance and p H data analysis were performed automatically and manually. For impedance monitoring, reflux was defined as a retrograde 50% drop in impedance, starting distally and propagating retrogradely to at least the next two more proximal measuring channels. Reflux index(RI, percentage of the entire record that esophageal p H is < 4.0) greater than 4.2% for p HM and number of refluxes more than 50 for 24 h for MII were accepted as positive test results. At scintigraphy, 240 frames of 15 seconds duration were acquired in the supine position. Gastroesophageal reflux was defined as at least one reflux episode in the esophagus. After scintigraphic evaluation, impedance-pH recordings and scintigraphic images were evaluated together and agreement between tests were evaluated with Cohen's kappa.RESULTS Sufficient data was obtained from 60(80%) patients(34 male, 56.7%) with a mean age of 8.7 ± 3.7 years(range: 2.5-17.3 years; median: 8.5 years). Chronic cough, nausea, regurgitation and vomiting were the most frequent symptoms. The mean time for recording of MII-pH M was 22.8 ± 2.4 h(range: 16-30 h; median: 22.7 h). At least one test was positive in 57(95%) patients. According to diagnostic criteria, GERD was diagnosed in 34(57.7%), 44(73.3%), 47(78.3%) and 51(85%) patients by means of p HM, MII, GES and MII-p HM, respectively. The observed percentage agreements/κ values for GES and p HM, GES and MII, GES and MII-p HM, and MII and p HM are 48.3%/-0.118; 61.7%/-0.042; 73.3%/0.116 and 60%/0.147, respectively. There was no or slight agreement between GES and p HM alone, MII alone or MII-p HM. p H monitoring alone missed 17 patients compared to combined MII-p HM. The addition of MII to pH monitoring increased the diagnosis rate by 50%.CONCLUSION No or slight agreement was found among p H monitoring, MII monitoring, MII-pH monitoring and GES for the diagnosis of gastroesophageal reflux disease. | Nuray Uslu Kizilkan Murat Fani Bozkurt Inci Nur Saltik Temizel Hülya Demir Aysel Yüce Biray Caner Hasan Ozen | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 3 | Effects of two different regimensof continuous hormone replacement therapy on endometrialhistopathology and postmenopausal uterine bleeding显示文摘 | Yildirin G Tugrul S Uslu H | 2006 | JAMA2006，273，5： | 1 |
| 4 | The evaluation of polycythemic newborns:efficacy of partial exchange transfusion显示文摘 | Uslu S Ozdemir H Bulbul A | 2011 | J Matern Fetal Neonatal Med2011，24，12： | 1 |
| 5 | A comparative study foradsorptionof methylene blue &om aqueous solutions by twddnds of ambo'lite resinmaterials显示文摘 | KERKEZ 0 BAYAZIT S USLU H | 2012 | Desalin Water Treat2012，45，： | 1 |
| 6 | Equilibrium studies of extraction of levulinic acid by ( trioc, tylamine ( TOA ) + ester) solvents 显示文摘 | Uslu H Kirbaslar S I | 2008 | Journal of Chemical & Engineering Data2008，53，7： | 1 |
| 7 | Comparison of laparoscopic and open adrenalectomy显示文摘 | BULUS H USLU H Y KARAKOYUN R | 2013 | Acta Chir Belg2013，113，3： | 1 |
| 8 | Reactive extraction of levulinic acid by amberlite LA-2 extractant显示文摘 | Uslu H Kirbaslar S I Wasewar K L | 2009 | Journal of Chemical & Engi- neering Data2009，54，3： | 1 |
| 9 | Resistance of Dasypyrum villosum to the cereal eyespot pathogens, Tapesia yallundae and Tapesia acuformis显示文摘 | USLU E MILLER T E REZANOOR N H | 1998 | Euphytica1998，103，2： | 1 |
| 10 | serum adenosine deaminase activity in pulmonary tuberculosis 显示文摘 | Alatas F Uslu S Moral H | 2003 | Tuberk Toraks2003，51，3： | 1 |
| 11 | Rootstock adaptation and affinity studies on Razaki and Muskule grape varieties 显示文摘 | Samanci H Uslu I | 1995 | Ataturk Central Horticultural Research lnst1995，30，： | 1 |
| 12 | Expression of caspase --3, p53 and Bel--2 in generalized aggressive periodontitis显示文摘 | Bulut S Uslu H Ozdemir BH | 2006 | Head Face Med2006，2，： | 1 |
| 13 | Resistance of Dasypyrum villosum to the cereal eyespot pathogens, Tapesia yaUundae and Tapesia acuformis 显示文摘 | Uslu E Miller T E Rezanoor N H | 1998 | Euphytica1998，103，2： | 1 |
| 14 | Coronary flow velocity reserve and carotid intima media thickness in patients with autosomal dominant polycystic kidney disease:from impaired tubules to impaired carotid and coronary arteries显示文摘 | Turkmen K Oflaz H Uslu B | 2008 | Clin J Am Soc Nephrol2008，3，4： | 1 |
| 15 | The effect of low-dose heparin on maintaining peripherally inserted percutaneous central venous catheters in neonates显示文摘 | Uslu S Ozdemir H Comert S | 2010 | J Perinatol2010，30，12： | 1 |
| 16 | The effect of Cd(Ⅱ), Pb(Ⅱ) and Cu(Ⅱ) ions on the growth and bioaccumulation properties of Rhizopus arrhizus显示文摘 | Uslu G Dursun A Y Ekiz H I | 2003 | Process Biochemistry2003，39，1： | 1 |
| 17 | Effects of two different regimens of continuous hormone replacement therapy on endometrial histopathology and postmenopausal uterine hleeding 显示文摘 | Yildirin G Tugrul S Uslu H | 2006 | JAMA2006，273，5： | 1 |
| 18 | Is there a safe area for theaxillary nerve in the deltoid muscle a cadaveric study显示文摘 | CETIK O USLU M ACAR H I | 2006 | J Bone Joint Surg Am2006，88，： | 1 |
| 19 | Doppler uhrasonog- raphy findings of splenic arterial steal syndrome after liver transplant 显示文摘 | Uslu N Asian H Tore H G | 2012 | Exp Clin Transplant2012，10，4： | 1 |
| 20 | Adsorption equilibria of formic acid by weaklybasic adsorbent Amberlite IRA-67 : equilibrium,kinet-ics ,thermodynamic 显示文摘 | USLU H | 2009 | Chemical Engineering Journal2009，155，1： | 1 |
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