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| 1 | Current management of hepatocellular carcinoma:An Eastern perspective显示文摘Hepatocellular carcinoma(HCC) is one of the leading causes of cancer death, especially in Eastern areas. With advancements in diagnosis and treatment modalities for HCC, the survival and prognosis of HCC patients are improving. However, treatment patterns are not uniform between areas despite efforts to promote a common protocol. Although many hepatologists in Asian countries may adopt the principles of the Barcelona Clinic Liver Cancer staging system, they are also independently making an effort to expand the indications of each treatment and to combine therapies for better outcomes. Several expanded criteria for liver transplantation in HCC have been developed in Asian countries. Living donor liver transplantation is much more commonly performed in these countries than deceased donor liver transplantation, and it may be preceded by other treatments such as the down-staging of tumors. Local ablation therapies are often combined with transarterial chemoembolization( TACE) and the outcome is comparable to that of surgical resection. The indications of TACE are expanding, and there are new types of transarterial therapies. Although data on drug-eluting beads, TACE, and radioembolization in Asian countries are still relatively sparse compared with Western countries, these methods are gradually gaining popularity because of better tolerability and the possibility of improved response rates. Hepatic arterial infusion chemotherapy and radiotherapy are not included in Western guidelines, but are currently being used actively in several Asian countries. For more advanced HCCs, appropriate combinations of TACE, radiotherapy, and sorafenib can be considered, and emerging data indicate improved outcomes of combination therapies compared with single therapies. To include these paradigm shifts into newer treatment guidelines, more studies may be needed, but they are certainly in progress. | Hyung Joon Yim Sang Jun Suh Soon Ho Um | 2015 | World Journal of Gastroenterology2015，21，13： | 26 |
| 2 | Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B显示文摘AIM:To investigate retrospectively the long-term efficacy of various treatment strategies using adefovir dipivoxil(adefovir) in patients with lamivudine-resistant chronic hepatitis B.METHODS:We included 154 consecutive patients in two treatment groups:the 'add-on' group(n = 79),in which adefovir was added to ongoing lamivudine treatment due to lamivudine resistance,and the 'switch/combination' group(n = 75),in which lamivudine was first switched to adefovir and then re-added later as needed.The 'switch/combination' group was then divided into two subgroups depending on whether participants followed(group A,n = 30) or violated(group B,n = 45) a proposed treatment strategy that determined whether to add lamivudine based on the serum hepatitis B virus(HBV) DNA levels(< 60 IU/mL or not) after 6 mo of treatment(roadmap concept).RESULTS:The cumulative probability of virologic response(HBV DNA < 60 IU/mL) was higher in group A than in the 'add-on' group and in group B(P < 0.001).In contrast,the cumulative probability of virologic breakthrough was lower in the 'add-on' group than in group B(P = 0.002).Furthermore,the risk of virologic breakthrough in the multivariate analysis was significantly lower in the 'add-on' group than in group A(hazard ratio = 0.096;95%CI,0.015-0.629;P = 0.015).CONCLUSION:The selective combination of adefovir with lamivudine based upon early treatment responses increased the odds of virologic breakthrough relative to the use of uniform combination therapy from the beginning of treatment. | Tae Jung Yun Jin Yong Jung Chang Ha Kim Soon Ho Um Hyonggin An Yeon Seok Seo Jin Dong Kim Hyung Joon Yim Bora Keum Yong Sik Kim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2012 | World Journal of Gastroenterology2012，18，47： | 19 |
| 3 | A hydrometallurgical method of energy saving type for separation of rare earth elements from rare earth polishing powder wastes with middle fraction of ceria显示文摘This study described a hydrometallurgical method to investigate the separation of rare earth elements(REEs)from rare earth polishing powder wastes(REPPWs)containing large amounts of rare earth oxides with a major phase of CeO_2 and minor phases of La_2O_3,Pr_2O_3,and Nd_2O_3 using a process devised by the authors.The suggested approach consisted of five processes:the synthesis of NaR E(SO_4)_2·xH_2O from rare earth oxides in Na_2SO_4-H_2SO_4-H_2 O solutions(Process 1),the conversion of NaR E(SO_4)_2·xH_2O into RE(OH)_3 using NaO H(Process 2),and the oxidation of Ce(OH)_3 into Ce(OH)_4 using air with O_2 injection(Process 3),followed by Processes 4 and 5 for separation of REEs by acid leaching using HCl and H_2SO_4,respectively.To confirm the high yield of NaR E(SO_4)_2·xH_2O in Process 1,experiments were carried out under various Na_2SO_4 concentrations(0.4–2.5 mol/L),sulfuric acid concentrations(6–14 mol/L),and reaction temperatures(95–125 oC).In addition,the effect of the pH value on the separation of Ce(OH)_4 in HCl-H_2 O solutions with Ce(OH)_4,La-,Pr-,and Nd(OH)_3 in Process 4 was also investigated.On the basis of above results,the possibility of effective separation of REEs from REPPWs could be confirmed. | UM Namil HIRATO Tetsuji | 2016 | Journal of Rare Earths2016，34，5： | 13 |
| 4 | Prognostic value of inflammation-based markers in patients with pancreatic cancer administered gemcitabine and erlotinib显示文摘AIM: To evaluate the value of systemic inflammationbased markers as prognostic factors for advanced pancreatic cancer(PC). METHODS: Data from 82 patients who underwent combination chemotherapy with gemcitabine and erlotinib for PC from 2011 to 2014 were collected retrospectively. Data that included the neutrophil-to-lymphocyte ratio(NLR), the platelet-to-lymphocyte ratio, and the C-reactive protein(CRP)-to-albumin(CRP/Alb) ratio were analyzed. Kaplan-Meier curves, and univariate and multivariate Cox proportional hazards regression analyses were used to identify the prognostic factors associated with progression-free survival(PFS) and overall survival(OS). RESULTS: The univariate analysis demonstrated the prognostic value of the NLR(P = 0.049) and the CRP/Alb ratio(P = 0.047) in relation to PFS, and a positiverelationship between an increase in inflammation-based markers and a poor prognosis in relation to OS. The multivariate analysis determined that an increased NLR(hazard ratio = 2.76, 95%CI: 1.33-5.75, P = 0.007) is an independent prognostic factor for poor OS. There was no association between the PLR and the patients' prognoses in those who had received chemotherapy that comprised gemcitabine and erlotinib in combination. The Kaplan-Meier method and the log-rank test determined significantly worse outcomes in relation to PFS and OS in patients with an NLR > 5 or a CRP/Alb ratio > 5.CONCLUSION: Systemic inflammation-based markers, including increases in the NLR and the CRP/Alb ratio, may be useful for predicting PC prognoses. | Jae Min Lee Hong Sik Lee Jong Jin Hyun Hyuk Soon Choi Eun Sun Kim Bora Keum Yeon Seok Seo Yoon Tae Jeen Hoon Jai Chun Soon Ho Um Chang Duck Kim | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 12 |
| 5 | GNAQ和GNA11体细胞突变导致先天性血管瘤发生显示文摘先天性血管瘤是一种出生前形成的罕见的血管性肿瘤。出生后肿瘤快速消退(RICH)或部分消退(NICH)。该文作者提出假设,体细胞突变导致先天性血管瘤发生。对8例患儿进行m RNA测序。 | Ayturk UM Couto JA Hann S | 2016 | 中国口腔颌面外科杂志2016，14，3： | 11 |
| 6 | 废弃钻井液无害化处理技术研究进展显示文摘在调研大量文献基础上,论述了废弃钻井液无害化处理技术的工作方式以及应用情况,对不同技术做了对比,总结了近几年废弃水基钻井液与废弃油基钻井液无害化处理工艺体系与应用情况。提出与多学科相结合,不断开发适应性更强的新技术仍是未来废弃钻井液无害化处理的主要方向,更应遵循“强化源头、控制过程”的治理思路,以期为相关研究提供借鉴和参考。 | 杨双春 佟双鱼 李东胜 李萍 KHISAYNOV UMED 孙孟莹 | 2019 | 应用化工2019，48，12： | 10 |
| 7 | Modeling height–diameter relationship for Populus euphratica in the Tarim riparian forest ecosystem, Northwest China显示文摘Modeling height–diameter relationships is an important component in estimating and predicting forest development under different forest management scenarios. In this paper, ten widely used candidate height–diameter models were fitted to tree height and diameter at breast height(DBH)data for Populus euphratica Oliv. within a 100 ha permanent plots at Arghan Village in the lower reaches of the Tarim River, Xinjiang Uyghur Autonomous Region of China. Data from 4781 trees were used and split randomly into two sets:75 % of the data were used to estimate model parameters(model calibration), and the remaining data(25 %) were reserved for model validation. All model performances were evaluated and compared by means of multiple model performance criteria such as asymptotic t-statistics of model parameters, standardized residuals against predicted height,root mean square error(RMSE), Akaike's informationcriterion(AIC), mean prediction error(ME) and mean absolute error(MAE). The estimated parameter a for model(6) was not statistically significant at a level of a = 0.05. RMSE and AIC test result for all models showed that exponential models(1),(2),(3) and(4) performed significantly better than others. All ten models had very small MEs and MAEs. Nearly all models underestimated tree heights except for model(6). Comparing the MEs and MAEs of models, model(1) produced smaller MEs(0.0059) and MAEs(1.3754) than other models. To assess the predictive performance of models, we also calculated MEs by dividing the model validation data set into 10-cm DBH classes. This suggested that all models were likely to create higher mean prediction errors for tree DBH classes[20 cm. However, no clear trend was found among models.Model(6) generated significantly smaller mean prediction errors across all tree DBH classes. Considering all the aforementioned criteria, model(1): TH ? 1:3 t a= e1 t b?eàc?DBHT and model(6): TH ? 1:3 t DBH2= ea t b?DBH t c ? DBH2T are recommended as suitable models for describing the height–diameter relationship of P. euphratica. The limitations of other models showing poor performance in predicting tree height are discussed. We provide explanations for these shortcomings. | Tayierjiang Aishan Umüt Halik Florian Betz Philipp Gartner Bernd Cyffka | 2016 | Journal of Forestry Research2016，27，4： | 9 |
| 8 | Exophytic inflammatory myofibroblastic tumor of the stomach in an adult woman:A rare cause of hemoperitoneum显示文摘Inflammatory myofibroblastic tumor (IMT) of the stomach in adults is extremely rare, with unpredictable prognosis. We present a 55-year-old woman with a gastric IMT. She experienced sudden abdominal pain 4 d previously. Physical examination showed mild abdominal tenderness in the hypogastrium, but no palpable abnormal abdominal mass. Abdominal CT showed a mass of approximately 8 cm in the gastrocolic ligament. On laparoscopic exploration, unexpected hemoperitoneum of approximately 1.5 L of blood was found, and an exophytic gastric mass of approximately 10 cm, appeared from the anterior wall of the gastric body along the greater curvature. Laparoscopy further showed that non-clotting blood in the abdominal cavity seemed to be from the gastric tumor. After conversion to open surgery for more precise evaluation of the cause of hemoperitoneum and the large friable tumor, gastric wedge resection, including the tumor, was conducted. The final diagnosis was consistent with IMT that originated from the gastric wall. | Seong-Heum Park Jong-Han Kim Byung Wook Min Tae Jin Song Gil Soo Son Seung Joo Kim Sang Woo Lee Hwan-Hoon Chung Ju Han Lee Jun Won Um | 2008 | World Journal of Gastroenterology2008，14，1： | 8 |
| 9 | HPLC-ABTS^+·在线法筛选细叶杜香叶部抗氧化活性成分显示文摘利用HPLC-ABTS+.在线法对细叶杜香叶中的抗氧化活性成分进行筛选和分析鉴定,结果表明:在细叶杜香甲醇提取物的乙酸乙酯萃取组分中筛选到2种抗氧化活性成分,经质谱和核磁共振波谱分析鉴定为染料木苷和槲皮素。 | 裴世春 徐玖亮 UM Byunghun 商亚芳 | 2012 | 食品科学2012，33，19： | 8 |
| 10 | Endoscopic submucosal tunnel dissection salvage technique for ulcerative early gastric cancer显示文摘Endoscopic submucosal dissection is an effective treatment modality for early gastric cancer(EGC), though the submucosal fibrosis found in ulcerative EGC is an obstacle for successful treatment. This report presents two cases of ulcerative EGC in two males, 73- and 80-year-old, with severe fibrosis. As endoscopic ultrasonography suggested that the EGCs had invaded the submucosal layer, the endoscopic submucosal tunnel dissection salvage technique was utilized for complete resection of the lesions. Although surgical gastrectomy was originally scheduled, the two patients had severe coronary heart disease, and surgeries were refused because of the risks associated with their heart conditions. The endoscopic submucosal tunnel dissection salvage technique procedures described in these cases were performed under conscious sedation, and were completed within 30 min. The complete en bloc resection of EGC using endoscopic submucosal tunnel dissection salvage technique was possible with a free resection margin, and no other complications were noted during the procedure. This is the first known report concerning the use of the endoscopic submucosal tunnel dissection salvage technique salvage technique for treatment of ulcerative EGC. We demonstrate that endoscopic submucosal tunnel dissection salvage technique it is a feasible method showing several advantages over endoscopic submucosal dissection for cases of EGC with fibrosis. | Hyuk Soon Choi Hoon Jai Chun Min Ho Seo Eun Sun Kim Bora Keum Yeon Seok Seo Yoon Tae Jeen Hong Sik Lee Soon Ho Um Chang Duck Kim Ho Sang Ryu | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 11 | 低密度支撑剂研究进展显示文摘低密度支撑剂是通过化学改性、物理改性等方法制备得到的高性能支撑剂,具有密度低、沉降速度低等特性。本文在调研大量文献基础上,根据改性方法不同将低密度支撑剂分为多孔无包覆陶瓷低密度支撑剂、多孔无机物包覆低密度支撑剂、多孔树脂包覆低密度支撑剂,对比了不同类型低密度支撑剂制备体系组成、密度以及承压性能,总结了制备不同类型低密度支撑剂的机理、主要影响因素及应用情况。根据制备方式不同将超低密度支撑剂(ultra-light weight proppants, ULWP)分为常规方法制备、新技术制备两类。提出未来可通过结合使用多种添加剂、优化烧制工艺等方式探索莫来石相、刚玉相等晶体结构,实现支撑剂超低密度与高强度的有效结合,利用疏水改性、结构改性等方式向多功能、高性能发展,为相关研究提供借鉴和参考。 | 杨双春 佟双鱼 李东胜 KHISAYNOV Umed 郭明哲 徐明磊 | 2019 | 化工进展2019，38，9： | 7 |
| 12 | Comparison of sequential and 7-,10-,14-d triple therapy for Helicobacter pylori infection显示文摘AIM:To compare the effectiveness of sequential therapy for Helicobacter pylori(H.pylori) infection with that of triple therapy of varying durations.METHODS:The 460 patients enrolled in this study had H.pylori-associated gastritis or a gastric or duodenal ulcer.After screening,H.pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7,10 or 14 d,or a new 10-d sequential therapy.Each of the 4 treatment groups included 115 patients.The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology.RESULTS:The overall eradication rate was 81.0%,and eradication rates were 75.7% for 7-d conventional triple therapy,81.9% for 10-d conventional triple therapy,84.4% for 14-d conventional triple therapy,and 82.0% for 10-d sequential therapy.Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy(P = 0.416 and P = 0.405,respectively).CONCLUSION:There are no significant differences between 10-d sequential eradication therapy for H.pylori and any duration of standard triple treatment in Korean patients. | Hyuk Soon Choi Hoon Jai Chun Sang Hoon Park Bora Keum Yeon Seok Seo Yong Sik Kim Yoon-Tae Jeen Soon Ho Um Hong Sik Lee Chang Duck Kim Ho Sang Ryu | 2012 | World Journal of Gastroenterology2012，18，19： | 7 |
| 13 | Risk factors causing structural sequelae after anastomotic leakage in mid to low rectal cancer显示文摘AIM: To investigate the risk factors causing structural sequelae after anastomotic leakage in patients with mid to low rectal cancer.METHODS: Prospectively collected data of consecutive subjects who had anastomotic leakage after surgical resection for rectal cancer from March 2006 to May 2013 at Korea University Anam Hospital were retrospectively analyzed. Two subgroup analyses were performed. The patients were initially divided into the sequelae(stricture, fistula, or sinus) and no sequelae groups and then divided into the permanent stoma(PS)and no PS groups. Univariate and multivariate analyses were performed to identify the risk factors of structural sequelae after anastomotic leakage.RESULTS: Structural sequelae after anastomotic leakage were identified in 29 patients(39.7%).Multivariate analysis revealed that diversion ileostomy at the first operation increases the risk of structural sequelae [odds ratio(OR) = 6.741; P = 0.017].Fourteen patients(17.7%) had permanent stoma during the follow-up period(median, 37 mo). Multivariate analysis showed that the tumor level from the dentate line was associated with the risk of permanent stoma(OR = 0.751; P = 0.045).CONCLUSION: Diversion ileostomy at the first operation increased the risk of structural sequelae of the anastomosis, while lower tumor location was associated with the risk of permanent stoma in the management of anastomotic leakage. | Woong Bae Ji Jung Myun Kwak Jin Kim Jun Won Um Seon Hahn Kim | 2015 | World Journal of Gastroenterology2015，21，19： | 6 |
| 14 | 基于HPLC-ABTS体系筛选细叶杜香抗氧化活性成分显示文摘细叶杜香(Ledum palustre L.var.Angustum E.Busch)是我国北方常用药用材料,有止咳祛痰、平喘、扩张血管等功效。本文利用HPLC-ABTS+在线筛选体系对细叶杜香茎部的抗氧化活性成分进行了筛选和分析检测,实验结果表明:细叶杜香茎部甲醇提取物中含有大量抗氧化活性成分,其中经二氯甲烷萃取后纯化的一个组分通过核磁共振波普分析鉴定为秦皮素,该研究为细叶杜香中更多抗氧化活性物质的筛选提供了基础性实验依据。 | 耿雪飞 郑永杰 赵明 UM Byunghun | 2011 | 化学工程师2011，25，10： | 6 |
| 15 | Bacteriuria in patients with indwelling urethral catheter in Owerri Municipality,Nigeria显示文摘Objective:Bacteriuria in patients with indwelling urethral catheter in Owerri Municipality of Imo State,Nigeria was studied.Methods: A total of 500 early morning mid stream urine samples from patients admitted in different hospitals within the Municipality.The samples were microbiologically analysed using cultural methods on different isolation media.Results: A total of 220 isolates were identified.Identification tests showed the presence of Escherichia coli(10%),Staphylococcus aureus(9.0%),Klebsiella Sp.(7.0%),Proteus Sp.(5.8%),Streptococcus faecalis(4.0%),Pseudomonas aeruginosa(3.8%),Citrobacter Sp.(2.8%) and Enterobacter Sp.(1.6%).Samples obtained from patients aged 71-80 years had the highest incidence of bacteria.A total of 120(48.0%) of the isolates were obtained from female patients.Out of these 12.0% were identified as Escherichia coli.Result,further show that long duration catherized patients of up to 29 days and above have more bacteriuria infection than short term indwelling catheter.Conclusion: These findings have greatly implicated indwelling catheter as a major cause of bacteriuria in catheterized patients. | Chukwuocha UM Dozie UW | 2011 | 海南医学院学报2011，17，2： | 5 |
| 16 | 胸腔镜治疗贲门失弛症显示文摘胸腔镜治疗贲门失弛症何启才BrynerUM王永清郦志军章文晓何正富作者单位:310016浙江医科大学附属邵逸夫医院心胸外科(何启才、王永清、郦志军、章文晓、何正富);美国罗马琳达大学医学中心外科(BrynerUM)1996年2月至4月我们应用胸腔镜行... | 何启才 Bryner UM 王永清 郦志军 章文晓 何正富 | 1998 | 中华胸心血管外科杂志1998，14，4： | 5 |
| 17 | Local Variability in Temperature, Humidity and Radiation in the BaekduDaegan Mountain Protected Area of Korea显示文摘A novel embedded sensor network records changes in key climatic-environmental variables over a range of altitude in the BaekduDaegan Mountain (BDM) of Gangwon Province in Korea, a protected mountain region with unique biodiversity undergoing climate change research. The investigated area is subdivided into three horizontal north-south study areas. Three variables, temperature (T, ℃), relative humidity (RH, %), and light intensity (LI, lumens m -2 , or lux, lx), have been continuously measured at hourly intervals from June, 2010 to September, 2011 using HOBO H8 devices at 10 fixed study sites. These hourly observations are aggregated to monthly, seasonal and annual mean values, and results are summarized to inaugurate a long-term climate change investigation. A region wide T difference in accordance with altitude, or lapse rate, over the interval is calculated as 0.4℃100 m -1 . T lapse rates change seasonally, with winter lapse rates being greater than those of summer. RH is elevated in summer compared to other seasons. LI within forestland is lower during summer and higher during other seasons. The obtained results could closely relate to the vegetation type and structure and the terrain state since data loggers were located in forestland. | CHAE Heemun LEE Hyunju LEE Sangsin CHEONG Yukyong UM Gijeung MARK Bryan PATRICK Nathan | 2012 | Journal of Mountain Science2012，9，5： | 5 |
| 18 | A novel cleansing score system for capsule endoscopy显示文摘AIM:To suggest a new cleansing score system for small bowel preparation and to evaluate its clinical efficacy.METHODS:Twenty capsule endoscopy cases were reviewed and small bowel preparation was assessed with the new scoring system.For the assessment,two visual parameters were used:proportion of visualized mucosa and degree of obscuration.Representative frames from small bowel images were serially selected and scored at 5-min intervals.Intraclass correlation coefficient(ICC)was obtained to assess the reliability of the new scoring system.For efficacy evaluation and validation,scores of our new scoring system were compared with another previously reported cleansing grading system.RESULTS:Concordance with the previous system,inter-observer agreement,and intra-patient agreement were excellent with ICC values of 0.82,0.80,and 0.76,respectively.The intra-observer agreements at four-week intervals were also excellent.The cutoff value of adequate image quality was found to be 2.25.CONCLUSION:Our new scoring system is simple,efficient,and can be considered to be applicable in clinical practice and research. | Sung Chul Park Bora Keum Jong Jin Hyun Yeon Seok Seo Yong Sik Kim Yoon Tae Jeen Hoon Jai Chun Soon Ho Um Chang Duck Kim Ho Sang Ryu | 2010 | World Journal of Gastroenterology2010，16，7： | 5 |
| 19 | Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis显示文摘AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METHODS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95%CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95%CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95%CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95%CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95%CI: 1.331-1.991, P < 0.001) and GWT (OR = 1.172, 95%CI: 1.024-1.342,P = 0.021) were independent factors for prolonged cholestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis. | Sang Jung Park Jin Dong Kim Yeon Seok Seo Beom Jin Park Min Ju Kim Soon Ho Um Chang Ha Kim Hyung Joon Yim Soon Koo Baik Jin Yong Jung Bora Keum Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2013 | World Journal of Gastroenterology2013，19，16： | 4 |
| 20 | Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma显示文摘AIM: To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC). METHODS: A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage Ⅲ and Ⅳ-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate 1 mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT. RESULTS: The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, α-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m ≥ 20% than in those with TRR1m < 20% (P < 0.001). CONCLUSION: RT is effective in treating advanced HCC with a tumor response rate of 56.9%. | Yeon Seok Seo Jin Nam Kim Bora Keum Sanghoon Park Yong Dae Kwon Yong Sik Kim Yoon Tae Jeen Hoon Jai Chun Chul Yong Kim Chang Duck Kim Ho Sang Ryu Soon Ho Um | 2008 | World Journal of Gastroenterology2008，14，15： | 4 |
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