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		题名	作者	年代	出处	被引量
	1	Design Management from a Contractor's Perspective: The Need for Clarity 显示文摘	Patricia Tzortzopoulos Rachel Cooper	2007	Architectural Engineering and Design Management2007，，3：	1
	2	Improving construction management prac- tice with the Last Planner System: a case study 显示文摘	ABDULLAH O A TZORTZOPOULOS F P KO- SKELA L	2014	Engineering Construction and Architectural Manage- ment2014，21，1：	1
	3	Design Management from a Contractor's Perspective:The Need for Clarity显示文摘	Patricia Tzortzopoulos Rachel Cooper		0，，03：	1
	4	Expression of Mammalian BM88/CEND1 in Drosophila Affects Nervous System Development by Interfering with Precursor Cell Formation显示文摘We used Drosophila melanogaster as an experimental model to express mouse and pig BM88/CEND1(cell cycle exit and neuronal differentiation 1) in order to investigate its potential functional effects on Drosophila neurogenesis. BM88/CEND1 is a neuron-specific protein whose function is implicated in triggering cells to exit from the cell cycle and differentiate towards a neuronal phenotype. Transgenic flies expressing either mouse or pig BM88/CEND1 in the nervous system had severe neuronal phenotypes with variable expressivity at various stages of embryonic development. In early embryonic stage 10,BM88/CEND1 expression led to an increase in the neuralspecific antigenicity of neuroectoderm at the expense of precursor cells [neuroblasts(Nbs) and ganglion mother cells(GMCs)] including the defective formation and differentiation of the MP2 precursors, whereas at later stages(12–15), protein accumulation induced gross morphological defects primarily in the CNS accompanied by a reduction of Nb and GMC markers. Furthermore, the neuronal precursor cells of embryos expressing BM88/CEND1 failed to carry out proper cell-cycle progression as revealed by the disorganized expression patterns of specific cell-cycle markers. BM88/CEND1 accumulation in the Drosophila eye affected normal eye disc development by disrupting the ommatidia. Finally, we demonstrated that expression of BM88/CEND1 modified/reduced the levels of activated MAP kinase indicating a functional effect of BM88/CEND1 on the MAPK signaling pathway. Our findings suggest that the expression of mammalian BM88/CEND1 in Drosophila exerts specific functional effects associated with neuronal precursor cell formation during embryonic neurogenesis and proper eye disc development.This study also validates the use of Drosophila as a powerful model system in which to investigate gene function and the underlying molecular mechanisms.	Athanasios Tzortzopoulos Dimitra Thomaidou Maria Gaitanou Rebecca Matsas Efthimios Skoulakis	2019	Neuroscience Bulletin2019，35，6：	1

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