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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Rivaroxaban versus enoxaparin for thromboprophylaxis after total, knee arthroplasty (RECORD4) : a randomised trial 显示文摘 | Turpie AG Lassen MR Davidson BL | 2009 | Lancet2009，373，： | 1 |
| 3 | Clinical outcomes with unfractionated heparin or low-molecular-weight heparin as bridging therapy in patients on long- term oral anticoagulants: the REGIMEN registry 显示文摘 | Spyropoulos AC Turpie AG Dunn AS | 2006 | J Thromb Haemost2006，4，6： | 1 |
| 4 | Randomised comparison of two intensities of oral anticoagulant therapy after tissue heart valve replacement 显示文摘 | Turpie AG Gunstensen J Hirsh J | 1988 | Lancet1988，1，： | 1 |
| 5 | Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4):a randomised trial显示文摘 | Turpie AG Lassen MR Davidson BL | 2009 | Lancet2009，373，9676： | 1 |
| 6 | Clinical outcomes with unfractionated heparin or low-molecular-weight heparin as bridging therapy in patients on long-term oral anticoagulants: the REGIMEN registry显示文摘 | Spyropoulos AC Turpie AGG Dunn AS | 2006 | J Thromb Haemost2006，4，6： | 1 |
| 7 | Sjogren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice显示文摘 | Turpie B Yoshimura T Gulati A | 2009 | Am J Pathol2009，175，3： | 1 |
| 8 | Prophylaxis of venous thromboembolism in stroke patients显示文摘 | Turpie AG | 1997 | Semin Thromb Hemost1997，23，： | 1 |
| 9 | Randomized,placebo-controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients显示文摘 | Leizorovicz A Cohen AT Turpie AG | | 0，，07： | 1 |
| 10 | The working for water programme : Evolution of a payments for ecosystem services mechanism that addresses both poverty and ecosystem service delivery in South Africa 显示文摘 | Turpie J K Marais C Blignaut J N | 2008 | Ecological Economics2008，65，4： | 1 |
| 11 | Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial显示文摘 | Turpie A G Lassen M R Davidson B L | 2009 | Lancet2009，373，9676： | 1 |
| 12 | Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4):a randomised trial显示文摘 | Turpie AG Lassen MR Davidson BL | | 0，，9676： | 1 |
| 13 | Venous thromboembolism risk in ischemic stroke patients receiving extended-duration enoxaparin prophylaxis: results from the EXCLAIM study显示文摘 | Turpie AG Hull RD Schellong SM | 2013 | Stroke2013，44，1： | 1 |
| 14 | Ptophylaxis of venous,thromboe mbolism in stroke pationts显示文摘 | Turpie AG | 1997 | Semin Thromb Hemost1997，23，： | 1 |
| 15 | Prophylasis of venous thromboembolism in stroke patients显示文摘 | Turpie AGG | 1997 | Semin Thromb Hemos1997，23，2： | 1 |
| 16 | Fondaparinux vs enoxa- parin for the prevention of venous thromboembolism in major or- thopedic surgery: a meta-analysis of 4 randomized double-blind studies显示文摘 | Turpie AG Bauer KA Eriksson BI | 2002 | Arch Intern Med2002，162，16： | 1 |
| 17 | Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty(RECORD4): a radomised trial显示文摘 | TURPIE AG LASSEN MR DAVIDSON BL | 2009 | Lancet2009，373，9676： | 1 |
| 18 | Rivaroxaban versus enox- aparin for thromboprophylaxis after total knee arthroplasty (RECORD4):a randomised trial显示文摘 | Turpie AG Lassen MR Davidson BL | 2009 | Lancet2009，373，9676： | 1 |
| 19 | Venous thromboembolism:pathophysiology,clinical features,and prevention显示文摘 | Turpie A G G Chin B S P Lip G Y H | 2002 | BMJ2002，325，7369： | 1 |
| 20 | Thromboembolism and pregnancy显示文摘 | Turpie AGG | 2001 | Inter Angiol2001，20，： | 1 |
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