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| 1 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 2 | Serum CA 125 levels in patients with chronic heart failure and accompanying pleural fluid 显示文摘 | Turk HM Pekdemir H Buyukberber S | 2003 | Tumour Siol2003，24，4： | 1 |
| 3 | The management of ADHD and associated problems in a young person with cleidocranial dysostosis (CCD) and mild intellectual disability 显示文摘 | McBrien H Turk J Letch N | 2006 | Clin Child Psychiatry2006，11，3： | 1 |
| 4 | Recognition of multi-scroll chaotic attractors using wavelet-based neural network and performance comparison of wavelet families显示文摘 | Turk M Ogras H | 2010 | Expert Systems with Applications2010，37，： | 1 |
| 5 | The management of ADHD and associated problems in a young person with cleidocranial dysos- tosis (CCD) and mild intellectual disability显示文摘 | McBrien H Turk J Letch N | 2006 | Clinical ChildPsychology and Psychiatry2006，11，3： | 1 |
| 6 | The role of tilt training in prevention recur-rent syncope in patientswith vasovagal syncope:a prospective and randomizedstudy显示文摘 | Duygu H Zoghi M Turk R | 2008 | PACE2008，31，： | 1 |
| 7 | Serum CA125 level sin patient s with chronic heart , failure and accompanyjng pleural fluid显示文摘 | Turk HM Pekdemir H BuyuberberS | 2003 | TumorBiol2003，24，4： | 1 |
| 8 | Serum CA 125 levels in patients with chronic heart failure and accompanying pleural fluid显示文摘 | Turk H M Pekdemir H Buyukberber S | 2003 | Tu- mottr Biol2003，24，4： | 1 |
| 9 | Sucrose Metabolism in Plastids 显示文摘 | Nathalie Gerrits Stefan C H J Turk Kees P M van Dun | 2001 | Plant Physiology2001，125，2： | 1 |
| 10 | Manage- ment of ureteric stones显示文摘 | Marberger M Hofbauer J Turk C H | 1994 | Eur Urol1994，25，： | 1 |
| 11 | Successful Skin Homografting From an Identical Twin in a Severely Burned Patient 显示文摘 | Turk E Karagulle E Turan H | 2014 | J Bum Care Res2014，35，3： | 1 |
| 12 | Assessment of stress-related psychophysiologcal reactions in chronic back pain patients显示文摘 | Flor H Turk DC Birbaumer N | 1985 | Journal of Consulting and Clinical Psychology1985，53，3： | 1 |
| 13 | Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A 显示文摘 | Schmidt H Turk V | 1988 | Proc Natl Acad Sci USA1988，85，18： | 1 |
| 14 | Fear of pain as a prognostic factor in chronic pain: conceptual models, assessment, and treatment implications显示文摘 | Turk C D Wilson H D | 2010 | Curr Pain Headache Rep2010，14，： | 1 |
| 15 | Placental ultrastructuralchanges and apoptosis in pregnancies with meconium stained amni-otic fluid 显示文摘 | Yurdakul Z TUrk z HK B lgen H | 2012 | Patoloji Derg2012，28，2： | 1 |
| 16 | The vacuolar sorting domain of sporamin transports GUS, but not levansucrase to the plant vacuole显示文摘 | DE ROOS K SCOTTI P A | 1997 | The New Phytologist1997，136，： | 1 |
| 17 | Acute retroviral syndrome and high baseline viral load are predictors of rapid HIV progression among un- treated Argentinean seroconverters 显示文摘 | Soclas ME Sued O Laufer N Lfzaro ME Mingrone H Pryluka D Remondegui C Figueroa MI Cesar C Gun A Turk G Bouzas MB Kavasery R Krolewiecki A P6rez H Salom6u H Cahn P Grupo Argentino de Seroconversi6r Study Group | 2011 | J Int AIDS Soc2011，14，1： | 1 |
| 18 | Enviromental conditions differentially affect vir gene induction in different Arobacterium strains: role of the VirA sensor protein 显示文摘 | Turk S C H J Melchers L S Dulk-Ras H D | 1991 | Plant Molecular Biology1991，16，： | 1 |
| 19 | Terrain synthesis from digital elevation models显示文摘 | ZHOU H SUN J TURK G | | 0，，04： | 1 |
| 20 | Exogenous progesterone application protects chickpea seedlings against chilling-induced oxidative stress显示文摘 | GENISEL M TURK H ERDAL S | | 0，，01： | 1 |
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