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| 1 | 3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease显示文摘Back pain is a common condition with a high social impact and represents a global health burden.Intervertebral disc disease(IVDD)is one of the major causes of back pain;no therapeutics are currently available to reverse this disease.The impact of bone mineral density(BMD)on IVDD has been controversial,with some studies suggesting osteoporosis as causative for IVDD and others suggesting it as protective for IVDD.Functional studies to evaluate the influence of genetic components of BMD in IVDD could highlight opportunities for drug development and repurposing.By taking a holistic 3D approach,we established an aging zebrafish model for spontaneous IVDD.Increased BMD in aging,detected by automated computational analysis,is caused by bone deformities at the endplates.However,aged zebrafish spines showed changes in bone morphology,microstructure,mineral heterogeneity,and increased fragility that resembled osteoporosis.Elements of the discs recapitulated IVDD symptoms found in humans:the intervertebral ligament(equivalent to the annulus fibrosus)showed disorganized collagen fibers and herniation,while the disc center(nucleus pulposus equivalent)showed dehydration and cellular abnormalities.We manipulated BMD in young zebrafish by mutating sp7 and cathepsin K,leading to low and high BMD,respectively.Remarkably,we detected IVDD in both groups,demonstrating that low BMD does not protect against IVDD,and we found a strong correlation between high BMD and IVDD.Deep learning was applied to high-resolution synchrotron\iCJ image data to analyze osteocyte 3D lacunar distribution and morphology,revealing a role of sp7 in controlling the osteocyte lacunar 3D profile.Our findings suggest potential avenues through which bone quality can be targeted to identify beneficial therapeutics for IVDD. | Erika Kague Francesco Turci Elis Newman Yushi Yang Kate Robson Brown Mona S.Aglan Ghada A.Otaify Sarnia A.Temtamy Victor L.Ruiz-Perez Stephen Cross C.Patrick Royall P.Eckhard Witten Chrissy L.Hammond | 2021 | Bone Research2021，9，4： | 2 |
| 2 | A rapid screening method for routine congener-specific analysis of polychlorinated biphenyls in human serum by high-resolution gas chromatography with mass spectrometric detection显示文摘 | TURCI R ANGELERI F MINOIA C | 2002 | Rapid Communications in Mass Spectrometry2002，16，20： | 1 |
| 3 | Moderately hypothermic cardiopulmonary bypass and low-flow antegrade selective cerebral perfusion for neonatal aortic arch surgery显示文摘 | Oppido G Pace Napoleone C Turci S | | 0，，06： | 1 |
| 4 | Critical evaluation of a high-throughput analytical method for polychlorinated biphenyls in human serum:Which detector for the establishment of the reference values显示文摘 | TURCI R MARIANI G MARINACCIO A | 2004 | Rapid Communications in Mass Spectrometry2004，18，4： | 1 |
| 5 | Moderately hy- pothermic cardiopulrnonary bypass and low - flow antegrate selective cerebral perfusion for neonatal aortic arch surgery显示文摘 | Oppido G napoleone C P Turci S | 2006 | Ann Thorac Surg2006，82，： | 1 |
| 6 | Moderately hypothermic cardiopulmonary bypass and low-flow antegrade selective cerebral perfusion for neonatal aortic arch surgery显示文摘 | Oppido G Napoleone C P Turci S | 2006 | Ann Thorac Surg2006，82，： | 1 |
| 7 | Quantita- tive analysis of rotational movements of knee in healthy sub- jects during treadmill barefoot walking显示文摘 | LOVECCHIO N GALANTE D TURCI M | 2008 | The Open Sports Medicine Journal2008，2，1： | 1 |
| 8 | The combination of oxalic acid with power ultrasound fully degrades chrysotile as- bestos fibres显示文摘 | Turci S Tomatis M Mantegma S | 2007 | Journal of Environmental Monitoring2007，9，： | 1 |
| 9 | Generalized equations of motion for the dynamic analysis of elastic mechanism systems显示文摘 | Turcie D A | 1984 | ASME Journal of Dynamic Systems Measurement and Control1984，，： | 1 |
| 10 | Incidence, etiology, histologic findings, and course of thoracic inflammatory aortopathies 显示文摘 | Pacini D Leone 0 Turci S | 2008 | Ann Thorac Surg2008，86，5： | 1 |
| 11 | Determination of dichloroanilines in human urine by gas chromatography/mass spectrometry: validation protocol and establishment of reference values in a population group living in central Italy显示文摘 | Turci R Barisano A Balducci C | 2006 | Rapid Commun Mass Spectrom2006，20，： | 1 |
| 12 | Iron-loaded synthetic chrysotile: a new model solid for studying the role of iron in as- bestos toxicity 显示文摘 | Gazzano E Turci F Foresti E | 2007 | Chem Res Toxico[2007，20，3： | 1 |
| 13 | Determination of methotrexate in human urine at trace levels by solid phase extraction and highperformance liquid chromatography/ tandem mass spectrometry 显示文摘 | Turci R Fiorentino ML Sottani C | 2000 | Rapid Commun Mass Spectrom2000，14，： | 1 |
| 14 | Iron-loaded synthetic ehryso- tile : a new model solid for studying the role of iron in asbestos tox- icity显示文摘 | Gazzano E Turci F Foresti E | 2007 | Chem Res Toxicol2007，20，3： | 1 |
| 15 | Polychlorinated biphenyl serum levels in two Italian population groups: sex pattern and correlation with age显示文摘 | Turci R Marinaccio A Balducci C | 2006 | Epidemiol Prey2006，30，2： | 1 |
| 16 | Nutrient leaching in a drip irrigationpeach orchard显示文摘 | StrabbioliG Turci E | 1995 | Acta Horticulturae1995，，383： | 1 |
| 17 | Moderately hypothermic cardiopulmonary bypass and low-flow antegrade selective cerebral perfusion for neonatal aortic arch surgery显示文摘 | OPPIDO G NAPOLEONE C P TURCI S | 2006 | Ann Thorac Surg2006，82，6： | 1 |
| 18 | Largrangian formulation of the equations of motion for elastic mechanism with mutual dependence between rigid body and elastic motions显示文摘 | Nagarajian S Turcis D A | 1990 | ASME Journal of Dynamic Systems Measurement & Control1990，，： | 1 |
| 19 | Iron-loaded synthetic chrysotile : a new model solid for studying the role of iron in asbestos toxicity 显示文摘 | Gazzano E Turci F Foresti E | 2007 | Chem Res Toxico12007，20，3： | 1 |
| 20 | Incidence, etiology, histologicfindings,and course of thoracic inflammatory aortopathies 显示文摘 | Pacini D Leone 0 Turci S | 2008 | Ann Thorac Surg2008，86，5： | 1 |
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