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| 1 | Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the prevention of vertical transmission of HBV infection显示文摘AIM:To evaluate the effects of tenofovir disoproxil fumarate(TDF)use during late pregnancy to reduce hepatitis B virus(HBV)transmission in highly viremic mothers.METHODS:This retrospective study included 45 pregnant patients with hepatitis B e antigen(+)chronic hepatitis B and HBV DNA levels>107copies/mL who received TDF 300 mg/d from week 18 to 27 of gestation(n=21).Untreated pregnant patients served as controls(n =24).All infants received 200 IU of hepatitis B immune globulin(HBIG)within 24 h postpartum and 20μg of recombinant HBV vaccine at 4,8,and 24 wk.Perinatal transmission rate was determined by hepatitis B surface antigen and HBV DNA results in infants at week 28.RESULTS:At week 28,none of the infants of TDFtreated mothers had immunoprophylaxis failure,whereas2(8.3%)of the infants of control mothers had immunoprophylaxis failure(P=0.022).There were no differences between the groups in terms of adverse events in mothers or congenital deformities,gestational age,height,or weight in infants.At postpartum week 28,significantly more TDF-treated mothers had levels of HBV DNA<250 copies/mL and normalized alanine aminotransferase compared with controls(62%vs none,P<0.001;82%vs 61%,P=0.012,respectively).CONCLUSION:TDF therapy during the second or third trimester reduced perinatal transmission rates of HBV and no adverse events were observed in mothers or infants. | Mustafa Kemal Celen Duygu Mert Müzeyyen Ay Tuba Dal Safak Kaya Necmettin Yildirim Serda Gulsun Tunga Barcin Sevgi Kalkanli Mehmet Sinan Dal Celal Ayaz | 2013 | World Journal of Gastroenterology2013，19，48： | 26 |
| 2 | Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery 显示文摘 | Isik B Arslan M Tunga A D | 2006 | Paediatr Anaesth2006，16，7： | 1 |
| 3 | Dexmedetomidine decreaesemergence agitation in pediatric patients after sevofluraneanesthesia without surgery 显示文摘 | Isik B Arslan M Tunga AD | 2006 | Pediatric Anesthesia2006，16，7： | 1 |
| 4 | Dexraedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesihesia without surgery显示文摘 | Isik B Arslan M Tunga AD | 2006 | Paediatr Anaesth2006，16，7： | 1 |
| 5 | Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery显示文摘 | ISIK B ARSLAN M TUNGA A D | 2006 | Paediatr Anaesth2006，16，7： | 1 |
| 6 | Dexmedetomidine decreases emergence agitation in pediatric patients ailer sevoflurane anesthesia without surgery显示文摘 | Isik B Arslan M Tunga AD | 2006 | Paediatr Anaesth2006，16，7： | 1 |
| 7 | Thrombopoietin levels of thrombocytopenic term and preterm newborns with infection显示文摘 | Oygur N Tunga M Mumcu Y | 2001 | Am J Perinatol2001，18，： | 1 |
| 8 | Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery显示文摘 | Isik B Arslan M Tunga AD | 2006 | Paediatr Anaesth2006，16，7： | 1 |
| 9 | Dexmedetomidine decreases e- mergence agitation in pediatric patients after sevoflttrane anesthesia without surgery显示文摘 | Isik B Arslan M Tunga AD | 2006 | Paediatr Anaesth2006，16，7： | 1 |
| 10 | Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery 显示文摘 | ISIK B ARSLAN M TUNGA A D | 2006 | Paediatr Anaesth2006，16，6： | 1 |
| 11 | Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery显示文摘 | Isik B Arslan M Tunga AD | 2006 | Paediatr Anaesth2006，16，7： | 1 |
| 12 | Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery 显示文摘 | ISIK B ARSLAN M TUNGA A D | 2006 | Paediatr Anaesth2006，16，7： | 1 |
| 13 | Dexmedetomidine decreases e- mergence agitation in pediatric patients after sevoflurane anesthesia without surgery显示文摘 | Isik B Arslan M Tunga AD | 2006 | Paediatr Anaesth2006，16，7： | 1 |
| 14 | Dexmedetomidine decreases e- mergence agination in pediatric patients after sevoflurane anesthesia without surgery 显示文摘 | Isik B ArslaNn M Tunga AD | 2006 | Paediatr Anaesth2006，16，7： | 1 |
| 15 | Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthe- sia without surgery显示文摘 | Isik B Arslan M Tunga AD | 2006 | Paediatr Anaesth2006，16，7： | 1 |
| 16 | Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery 显示文摘 | Isik B Arslan M Tunga AD | 2006 | Pediatr Anesth2006，16，7： | 1 |
| 17 | Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery 显示文摘 | Isik B Arslan M Tunga AD | 2006 | Pediatr Anesth2006，16，7： | 1 |
| 18 | Dexmedetomidine de creases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery显示文摘 | Isik B Arslan M Tunga AD | 2006 | Pediat Anesth2006，16，7： | 1 |
| 19 | Dexmedetomidine decrea- ses emergence agitation in pediatric patients after sevoflurane anesthesia without surgery 显示文摘 | Isik B Arslan M Tunga AD | 2006 | Pediatr Anesth2006，16，7： | 1 |
| 20 | Dexmedetomidine de- creses emergence agitation in pediatric patients after sevoflurane anesthesia without surgery 显示文摘 | ISIK B ARSLAN M TUNGA A D | 2006 | Pediatric Anesthesia2006，16，7： | 1 |
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