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| 1 | Keratinocyte 生长 factor-2 和自体同源的浆液加强处于在老鼠的角膜损坏的间充质的干细胞的再生效果显示文摘AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells(MSCs)cultured with or without keratinocyte growth factor(KGF-2)and autologous serum(AS)on amniotic membrane(AM).Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell deficiency.Bone marrow-derived MSCs are potential sources for cellbased tissue engineering to repair or replace the corneal tissue,having the potential to differentiate to epithelial cells.METHODS:The study included 5 groups each including 10 female'Sprague Dawley'rats in addition to20 male rats used as bone marrow donors.Group I rats received AM+MSCs,Group II rats AM+MSCs cultured with KGF-2,Group III rats AM+MSCs cultured with KGF-2+AS,Group IV rats only AM and Group V rats,none.AS was derived from blood drawn from male rats and bone marrow was obtained from the femur and tibia bones of the same animals.Therapeutic effect was evaluated with clinical,histopathological and immunohistochemical assessment.MSC engraftment was demonstrated via detection of donor genotype(Y+)in the recipient tissue(X)with polymerase chain reaction.RESULTS:Corneal healing was significantly better in Groups I-III rats treated with MSC transplantation compared to Group IV and Group V rats with supportive treatment only.The best results were obtained in Group III rats with 90%transparency,70%lack of neovascularization,and 100%epithelium damage limited to less than 1/4 of cornea.CONCLUSION:We suggest that culture of MSCs with KGF-2 and AS on AM is effective in corneal repair in case of irreversible damage to limbal stem cells. | Ferda Alpaslan Pinarli Gülsen Okten Umit Beden Tunc Fisgin Mehmet Kefeli Nurten Kara Feride Duru Leman Tomak | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Outrigger beam-wall connections I: component testing and development of design model 显示文摘 | SHAHROOZ B M DEASON J T TUNC G | 2004 | Journal of Structural Engineering2004，130，2： | 1 |
| 3 | Outrigger beam-wall connections 1I : subassembly testing and further modeling enhancements 显示文摘 | SHAHROOZ B M TUNC G DEASON J T | 2004 | Journal of Structural Engineering2004，130，2： | 1 |
| 4 | In situconformational analysis of fibrinogen adsorbed on Sisurfaces显示文摘 | TUNC S MAITZ M F STEINER G | 2005 | Colloids and Surfaces B:Biointerfaces2005，42，25： | 1 |
| 5 | Heat transfer in microtubes with viscous dissipation 显示文摘 | TUNC G BAYAZITOGLU Y | 2001 | Int d Heat and Mass Transfer2001，44，13： | 1 |
| 6 | A decomposition analysis of CO2 emissions from energy use :Turkish case 显示文摘 | TUNC G I ASIK S T AKBOSTANCI E | 2009 | Energy Policy2009，37，11： | 1 |
| 7 | An Overview of Reinforced Concrete Core Wall-steel Frame Hybrid Structures 显示文摘 | Shahrooz B M Gong B N Tunc G | 2001 | Progress in Structure Engineering and Materials ASCE2001，3，2： | 1 |
| 8 | β- Glycosidase (Amygdalase and Linamarase) from Endomyces Fibuliger (LU677) : Formation and Crude Enzyme Properties 显示文摘 | Brimer Nout M J R Tunce G | 1998 | Applied Microbiology and Biotechnology1998，49，2： | 1 |
| 9 | An overview of reinforced concrete core wall-steel frame hybrid structures 显示文摘 | Shahrooz B M Gong B N Tunc G Deason J T | 2001 | Progress in Structural Engineering and Materials2001，3，2： | 1 |
| 10 | A decomposition analysis of CO2 emissions from energy use: turkish case显示文摘 | Tunc G Ttirtit-Asik S Akbostanci E | 2009 | Energy Policy2009，37，11： | 1 |
| 11 | The relationship between income and environment in Turkey: Is there an environmental Kuznets curve? 显示文摘 | Akbostanci E Ttirtit-Asik S Tunc G I | 2009 | Energy Policy2009，37，3： | 1 |
| 12 | Pollution Haven Hypothesis and the Role of Dirty Industries in Turkey' s Exports 显示文摘 | Akbostanci E Tunc G L Ttirat - Asik S | 2007 | Environment and Development Economics2007，，12： | 1 |
| 13 | An overview of reinforced concrete core wall-steel frame hybrid structures显示文摘 | Shahrooz B M Gong B N Tunc G | 2001 | Progress in Structural Engineering and Materials2001，3，2： | 1 |
| 14 | The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy 显示文摘 | Patiroglu T Tunc A Eke G H | 2012 | Phytomcdicine2012，19，11： | 1 |
| 15 | C02 emissions of Turkishmanufacturing industry : A decomposition analysis 显示文摘 | AKBOSTANCI E TUNC G I’ ASIK S T | 2011 | Applied Ener-gy2011，88，6： | 1 |
| 16 | Apremilast for thetreatment of Beh^et^s syndrome: a phase II randomized, place-bo-controlled ,double-blind study显示文摘 | Hatemi G Melikoglu M Tunc R | 2013 | Arthritis Rheum2013，65，10： | 1 |
| 17 | Rhabdomyolysis in a patient with hy-pothyroidism显示文摘 | Kisakol G Tunc R Kaya A | 2003 | Endocr J2003，50，2： | 1 |
| 18 | CO2 Emissions vs CO2 Responsibility: An Input-Output Approach for the Turkish Economy显示文摘 | Tunc G I Ttjrtjt-Asik S Akbostanci E | 2007 | Enersy Policy2007，55，2： | 1 |
| 19 | An overview of reinforced concrete core wall-steel frame hybrid structures 显示文摘 | SHAHRCOZ B M GONG B N TUNC G | 2001 | Progress in Structural Engineering and Materials2001，3，2： | 1 |
| 20 | The impact of interest rate and exchange rate volatility on banks' stock returns and volatility: Evidence from Turkey 显示文摘 | KASMAN S VARDAR G TUNC G | 2011 | Economic Mod- elling2011，28，3： | 1 |
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