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| 1 | Gold nanorods with a hematoporphyrin-loaded silica shell for dual-modality photodynamic and photothermal treatment of tumors in vivo显示文摘由一个金 nanorod 核心和与 hematoporphyrin (HP ) 做的 mesoporous 硅石壳组成的 Nanocomposites (NC ) 被制作了以便由在 vivo 联合 photothermal 和光力学的治疗(太平洋夏季时间 + PTT ) 改进癌症治疗的效率。除了 810830 nm 附近的长波长的电浆子回声,制作 NC 展出了相应的一座 400-nm 吸收度山峰围住 HP,在 632.5-nm Q 乐队附近在 633-nm 刺激下面产生了汗衫氧,并且生产了在 808-nm 下面的热在红外线附近(NIR ) 激光照耀。这些形式被用于联合太平洋夏季时间 + PTT 治疗大(大约 3 cm3 ) 在有一只 xenorafted 肿瘤老鼠的 vivo 的稳固的肿瘤当模特儿。NC 直接被注入肿瘤并且与 633-nm 和 808-nm 激光同时照耀刺激联合光力学并且 NC 的 photothermal 活动。联合治疗的效率被光连贯断层摄影术评估,组织学的分析,并且由肿瘤体积生长的大小在一个 21 天的时期期间。调停 NC 的太平洋夏季时间在组织组织学并且到导致了弱变化一中等在肿瘤体积的 20% 减少。相反,联合太平洋夏季时间 + PTT 处理导致了大区域的肿瘤坏死并且在肿瘤体积导致了戏剧的减少。 | Georgy Terentyuk Elizaveta Panfilova Vitaly Khanadeev Daniil Chumakov Elina Genina Alexey Bashkatov Valery Tuchin Alia Bucharskaya Galina Maslyakova Nikolai Khlebtsov Boris Khlebtsov | 2014 | Nano Research2014，7，3： | 17 |
| 2 | Advances in small animal mesentery models for in vivo flow cytometry,dynamic microscopy,and drug screening显示文摘Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo. Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell’s functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo- and radio-sensitivity tests, and drug screening, are also discussed. | Ekaterina I Galanzha Valery V Tuchin Vladimir P Zharov | 2007 | World Journal of Gastroenterology2007，13，2： | 2 |
| 3 | A pilot study of ICG laser therapy of acne vulgaris:photodynamic and photothermolysis treatment显示文摘 | Genina EA Bashkatov AN | 2003 | Lasers Surg Med2003，33，5： | 1 |
| 4 | Tissue optical immer- sion clearing 显示文摘 | Genina EA Bashkatov AN Tuchin VV | 2010 | Expert Rev Med Devices2010，7，6： | 1 |
| 5 | A pilot study of ICG laser therapy of acne vulgaris:photodynamic and photothermolysis treatment显示文摘 | Tuchin VV Genina EA Bashkatov AN | 2003 | Lasers Surg Med2003，33，： | 1 |
| 6 | Coherence domain optical methods in biomedical science and clinical applications显示文摘 | Tuchin Y Y Lzatt J A Milner T E | 1999 | Proceed- ings of SPIE1999，3598，： | 1 |
| 7 | Tissue optics,light distribution,and spectroscopy显示文摘 | Tuchin V V Utz S R Yaroslavsky L V | 1994 | Opt Engineering1994，33，10： | 1 |
| 8 | Design and evaluation of a novel portable erythema-melanin-meter 显示文摘 | Dolotov LE Sinichkin YP Tuchin VV | 2004 | Lasers Surg Med2004，34，： | 1 |
| 9 | Characteristic Scales of Optical Field Depolarization and Decorrelation for Multiple Scattering Media and Tissues显示文摘 | ZIMNYAKOV D A TUCHIN V V YODH A G | 1999 | Journal of Biomedical Optics1999，4，1： | 1 |
| 10 | Optical properties of skin, subcutaneous, and muscle tissues: a review显示文摘 | Bashkatov AN Genina EA Tuchin VV | 2011 | J lnnov Opt Health Sc2011，4，01： | 1 |
| 11 | Optical properties of skin, subcutaneous, and muscle tissues: a review显示文摘 | Bashkatov AN Genina EA Tuchin VV | 2011 | J Innov Opt Health Sci2011，4，01： | 1 |
| 12 | Ocular surface epithelia express mRNA for human beta defensin 2显示文摘 | McNamara NA Van R Tuchin OS | 1999 | Exp Eye Res1999，69，： | 1 |
| 13 | Laser microspectral analysis of superthin evaporations of unknown composition 显示文摘 | SKURMENKO E L SOKOLOVA T N TUCHIN V V | 2001 | SPIE2001，4241，： | 1 |
| 14 | Ocular surface epithelia express mRNA for human beta defensin-2 显示文摘 | Mc NN Van R Tuchin OS | 1999 | Exp Eye Res1999，，5： | 1 |
| 15 | Synthesis of heterocyclic compounds containing three contiguous hydrogen bonding sites in all possible arrangements 显示文摘 | MURRAY T J ZIMMERMAN S C KOL()TUCHIN S V | 1995 | Tetrahedron1995，51，63： | 1 |
| 16 | Accessing to arteriovenous blood flow dynamics response using combined laser speckle contrast imaging and skin optical clearing显示文摘 | Shi R Chen M Tuchin VV | 2015 | Biomedical Optics Express2015，6，6： | 1 |
| 17 | Review of Topical Problems: Light Scatting Study of Tissues 显示文摘 | TUCHIN V V | 1997 | Physics-uspekhi1997，40，5： | 1 |
| 18 | Tissue Optics,Light Distribution and Spectroscopy显示文摘 | TUCHIN V V UTZ S R YAROSLAVSKY I V | 1994 | Optical Engineering1994，33，： | 1 |
| 19 | Tissue optical immersionclearing 显示文摘 | Genina EA Bashkatov AN Tuchin VV | 2010 | Expert Rev Med Devices2010，7，6： | 1 |
| 20 | A pilot study of ICG laser therapy of acne vulgaris: photodynamic and photothermolysis treatment显示文摘 | Tuchin VV Genina EA Bashkatov AN | 2003 | Lasers Surg Med2003，33，： | 1 |
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