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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 3 | Research on Service Life Prediction Model of Concrete Structure of Sea-crossing Bridge显示文摘According to the chloride corrosion environment,service life prediction model of concrete structure of sea-crossing bridge was built using modified Fick's second law and the whole probability calculation method,which was suitable for China. Furthermore,a visual service life prediction program of concrete structure was developed by optimized Monte Carlo method. Meanwhile,Life 365 program was compared,indicating reliability of the prediction program. Finally,the validity of prediction model was verified in JinTang Bridge of Zhoushan Island Mainland Linkage Project. | WANG C J ZHANG G Z LIU K X TU L Q LI J H QIN M Q | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 4 | Thermal-hydrodynamic modelling of bubbly flows with heat and mass transfer 显示文摘 | Yeoh G H Tu J Y | 2005 | AIChE Journal2005，51，： | 1 |
| 5 | Numerical modelling and validation of gas-particle flow in an in-line tube bank显示文摘 | Tian Z F Tu J Y Yeoh G H | 2007 | Computers & Chemical Engineering2007，31，9： | 1 |
| 6 | Enhanced low voltage cycling stability of LiMn204 cathode by ZnO coating for lithium ion batteries 显示文摘 | Tu J Zhao X B Xie J Cao G S Zhuang D G Zhu T J Tu J P | 2007 | Journal of Alloys and Compounds2007，432，12： | 1 |
| 7 | Green fluorescent protein as a marker for gene expression显示文摘 | Chalfie M Tu Y Euskirchen G | 1994 | Science1994，263，5148： | 1 |
| 8 | Green fluorescent protein as a marker for gene expression显示文摘 | Chalfie M Tu Y Euskirchen G | 1994 | Science1994，263，： | 1 |
| 9 | Ontogenesis of transthyretin gene expression in chicken choroids plexus and liver显示文摘 | Southwell B R Duan W Tu G F | 1991 | Comp Biochem Physiol1991，100，： | 1 |
| 10 | Green fluorescent protein as a marker for gene expression显示文摘 | Chalfie M Tu Y Euskirchen G | 1994 | Science1994，263，： | 1 |
| 11 | Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human显示文摘 | Song H Tu C Zhang G | 2005 | Proc Natl Acad Sci USA2005，102，7： | 1 |
| 12 | Distribution Characteristics of Vehicle Specific Power on Urban Restricted Access Roadways 显示文摘 | Song G L Yu Z Tu | 2012 | Journal of Transportation Engineering (S0733-947X) ASCE2012，138，： | 1 |
| 13 | Th e I m p act s of En e rgy Pric e son En ergy I nte n sity:Evid e n ce fro m Chin a显示文摘 | HAN G L M TU M Z | 2007 | En ergyPolicy2007，35，5： | 1 |
| 14 | In vitro induction of differentia- tion by ginsenoside in SMMC-7721 hepatocarcinoma cell line显示文摘 | ZENG X L TU Z G | 2003 | Pharmacol Toxico2003，93，： | 1 |
| 15 | Enhanced cycling stability of LiMn2O4 by surface modification with melting impregnation method 显示文摘 | Tu J Zhao X B Cao G S Zhuang D G Zhu T J Tu J P | 2006 | Electrochimica Acta2006，51，： | 1 |
| 16 | Microstructure,chemical and tribological investigations of MoxW1-xSy co-sputtered composite films显示文摘 | YIN G L HUANG P H YU Z HE D N TU J P | 2006 | Tribology Letters2006，22，1： | 1 |
| 17 | Diabetes self - care knowledge, behaviors,and metablic control of elder adults: the effect of a post - educational follow - up program显示文摘 | McDaniel G Gay JT | 1993 | Diabetes Educ1993，19，： | 1 |
| 18 | Green fluorescent protein as a marker for gene expression显示文摘 | Chalfie M Tu Y Euskirchen G | 1994 | Sci ence1994，263，： | 1 |
| 19 | Comparison of the incidences of left ventricular hypertrophy,left ventricular diastolic dysfunction,and arrhythmia between patients with dipper and non-dipper hypertension显示文摘 | Ersoylu ZD Tu(g)cu A Yildirimtürk O | 2008 | Turk Kardiyol Dern Ars2008，36，5： | 1 |
| 20 | Therapeutic Application of Ultra- sound-Guided 8-Gauge Mammotorne System in Presumed Benign Breast Lesions显示文摘 | Luo HJ Chen X Tu G | 2011 | Breast J2011，17，5： | 1 |
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