|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | Comparison of SSR and SNPs in assessment of genetic relatedness in maize显示文摘 | Xiaohong Yang Yunbi Xu Trushar Shah | 2011 | Genetica2011，139，： | 1 |
| 3 | High-throughput SNP genotyping with the Golden Gate assay in maize 显示文摘 | Yan JB Yang XH Trushar Sm Hector SV Li JS Marilyn W Zhou Y Crouch JH Xu YB | 2010 | Mol Breed2010，25，： | 1 |
| 4 | Molecular characterization of global maize breeding germplasm based on genome-wide single nucleotide polymorphisms显示文摘 | Yanli Lu Jianbing Yan Claudia T. Guimar?es Suketoshi Taba Zhuanfang Hao Shibin Gao Shaojiang Chen Jiansheng Li Shihuang Zhang Bindiganavile S. Vivek Cosmos Magorokosho Stephen Mugo Dan Makumbi Sidney N. Parentoni Trushar Shah Tingzhao Rong Jonathan H. Cro | 2009 | Theoretical and Applied Genetics2009，，1： | 1 |
| 5 | Damaged starchcharacterisation by ultracentrifugation 显示文摘 | Richard F T Trushar P Stephen E H | 2006 | CarbohydrateResearch2006，341，： | 1 |
| 6 | Numerical Analysis of Unsteady Natural Convection Flow and Heat Transfer in the Existence of Lorentz Force in Suddenly Expanded Cavity Using OpenFOAM显示文摘The present study reveals the significance of the magnetic field or Lorentz force on the unsteady natural convection flow and heat transfer in the suddenly expanded cavity.The Lorentz force based magnetohydrodynamics(MHD)solver using electric potential formulation coupled with the energy equation by the means of Boussinesq approximation is developed in the open-source CFD tool OpenFOAM.The unsteady flow is generated by the buoyancy force keeping the Rayleigh number(Ra)at 109,at the fixed Prandtl number(Pr)of 0.71.The effects of the magnetic field on the flow and heat transfer are explained for various orientations of magnetic field(Bx,B45,and By)in terms of Hartmann number(Ha=0,50,100,300 and 500).The increase in the magnetic field increases the strength of the Lorentz force,which regulates the flow pattern and suppresses down the unsteady nature of flow and heat transfer into the steady-state.It is perceived that the average Nusselt number decreases as the intensity of Bx and B45 magnetic field increases.However,for By magnetic field the average Nusselt number increases up to Ha of 100 as compared to the non-MHD case(Ha=0).The distribution of Lorentz force in the domain plays a significant role in the governing of the fluid flow and heat transfer. | SINGH Ranjit J. GOHIL Trushar B. | 2020 | Journal of Thermal Science2020，29，6： | 0 |
| 7 | A Comprehensive Transcriptome Assembly of Pigeonpea (Cajanus cajan L.) using Sanger and Second-Generation Sequencing Platforms显示文摘为 pigeonpea 的一个全面 transcriptome 集会被分析 IIx 单个结束读的 1.289 亿短 Illumina GA 开发了,结束 FLX/454 读的 219 万个单身者,和表示的 18353 Sanger 从超过 16 遗传型定序标签。结果的 transcriptome 集会,把 v2 叫作 CcTA,与 1510bp 的 N50 包括了 21434 抄本集会 contigs (TAC ) ,最大的 8kb。21434 TAC,(77.5%) 16622 能被印射在上在相当紧的排列参数下面造 1.0.9 到大豆染色体。基于 intron 连接的知识, 10009 教材对为放大跨越区域(ISR ) 的 intron 从 5033 TAC 被设计。由在作为一本参考书在大豆染色体上 pigeonpea 的 BAC-end-derived SSR loci 印射的 silico 使用,在染色体水平的通常认为的印射位置为 6284 个 ISR 标记被预言,盖住所有 11 个 pigeonpea 染色体。128 个 ISR 标记的一个子集在一套八遗传型上被分析。当 116 个标记被验证时, 70 个标记显示出一~三等位基因,与 0.16 多型性信息内容(照片) 的一般水准价值。在摘要, CcTA v2 抄本汇编和 ISR 标记将用作一个有用资源在 pigeonpea 加速基因研究和繁殖应用程序。 | Himabindu Kudapa Arvind K. Bharti Steven B. Cannon Andrew D. Farmer Benjamin Mulaosmanovi Robin Kramer Abhishek Bohra Nathan T. Weeks John A. Crow Reetu Tuteja Trushar Shah Sutapa Dutta Deepak K. Gupta Archana Singh Kishor Gaikwad Tilak R. Sharma Gregory D. May Nagendra K. Singh Rajeev K. Varshney | 2012 | Molecular Plant2012，5，5： | 0 |
| 8 | Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents显示文摘The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet elucidated.In this analysis,our study(NCT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-CoV-2 before and after a third dose of BNT162b2 in healthy adolescents.At 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 doses.The antibody responses and S-specific IFN-γ^(+)and IL-2^(+)CD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of BNT162b2.Compared to adults,humoral responses for the third dose were non-inferior or superior in adolescents.The S-specific IFN-γ^(+)and IL-2^(+)CD4^(+)and CD8^(+)T cell responses in adolescents and adults were comparable or non-inferior.Interestingly,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and BA.5.Sera from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise BA.1.Our study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease. | Xiaofeng Mu Carolyn A.Cohen Daniel Leung Jaime S.Rosa Duque Samuel M.S.Cheng Yuet Chung Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer H.Y.Lam Derek H.L.Lee Sau Man Chan Leo C.H.Tsang Karl C.K.Chan John K.C.Li Leo L.H.Luk Sara Chaothai Kelvin K.H.Kwan Nym Coco Chu Masashi Mori Trushar Jeevan Ahmed Kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung Lau | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员