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| 1 | The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation显示文摘There is a critical shortage of organs, cells, and corneas from deceased human donors worldwide. There are also shortages of human blood for transfusion. A potential solution to all of these problems is the transplantation of organs, cells, and corneas from a readily available animal species, such as the pig, and the transfusion of red blood cells from pigs into humans. However, to achieve these ends, major immunologic and other barriers have to be overcome. Considerable progress has been made in this respect by the genetic modification of pigs to protect their tissues from the primate immune response and to correct several molecular incompatibilities that exist between pig and primate. These have included knockout of genes responsible for the expression of major antigenic targets for primate natural anti-pig antibodies, insertion of human complementand coagulation-regulatory transgenes, and knockdown of swine leukocyte antigens that stimulate the primate's adaptive immune response. As a result of these manipulations, the administration of novel immunosuppressive agents, and other innovations, pig hearts have now functioned in baboons for 6-8 months, pig islets have maintained normoglycemia in diabetic monkeys for > 1 year, and pig corneas have maintained transparency for several months. Clinical trials of pig islet transplantation are already in progress. Future developments will involve further genetic manipulations of the organsource pig, with most of the genes that are likely to be beneficial already identified. | David K.C.Cooper Hidetaka Hara Mohamed Ezzelarab Rita Bottino Massimo Trucco Carol Phelps David Ayares Yifan Dai | 2013 | The Journal of Biomedical Research2013，27，4： | 6 |
| 2 | Use of genetically-engineered pig donors in islet transplantation显示文摘Type 1 diabetes(T1D) is an autoimmune disease wherein the pancreas does not produce enough insulin due to islet beta cell destruction. Despite improvements in delivering exogenous insulin to T1 D patients, pancreas or islet transplantation remains the best way to regulate their glycaemia. Results from experimental islet transplantation have improved dramatically in the last 15 years, to the point where it can be comparable to pancreas transplantation, but without the accompanying morbidity associated with this procedure. As with other transplants, the limiting factor in islet allotransplantation is the relatively small number of organs made available by deceased human donors throughout the world. A strong case can be made for islet xenotransplantation to fill the gap between supply and demand; however, transplantation across species presents challenges that are unique to that setting. In the search for the most suitable animal for human xenotransplantation, the pig has many advantages that make it the likely animal of choice. Potentially one of the most beneficial advantages is the ability to genetically engineer porcine donors to be more compatible with human recipients. Several genetic manipulations have already proven useful in relation to hyperacute rejection and inflammation(instant blood mediated inflammatory reaction), with the potential of even further advancement in the near future. | Rita Bottino Massimo Trucco | 2015 | World Journal of Transplantation2015，5，4： | 2 |
| 3 | A compact algorithm for rectification of stereo pairs 显示文摘 | Fusiello A Trucco E Vcrri A | 2000 | Machine Vision and Applications2000，12，1： | 1 |
| 4 | Cell migration and chimerism after whole-organ transplantation:the basis of graft acceptance显示文摘 | Starzl TE Demetris AJ Trucco M | 1993 | Hepatology1993，17，6： | 1 |
| 5 | Synthesis of unequally spaced arrays by simulat edannealing显示文摘 | Murino V Trucco A Regazzoni C S | | 0，，01： | 1 |
| 6 | 显示文摘 | Trucco C ctal | 1998 | J Nucl Acids Res1998，26，： | 1 |
| 7 | A compact algorithm for rectifi- cation of stereo pairs 显示文摘 | Fusiello A Trucco E Verri A | 2000 | Machine vision and applications2000，12，1： | 1 |
| 8 | Markerless hu- man articulated tracking using hierarchical particle swarm opti- mization显示文摘 | Vijay John emanuele Trucco Spela Ivekovic | 2010 | Image and Vision Computing2010，28，11： | 1 |
| 9 | Requirement of poly(ADP-ribose)polymerase in recovery from DNA damage in mice and cells显示文摘 | Murcia JM Niedergang C Trucco C | 2006 | Pro Nat Acad Sci2006，103，4： | 1 |
| 10 | Synthesis of unequally spaced arrays by simulated annealing显示文摘 | MURINO V TRUCCO A REGAZZONI C S | 1996 | IEEE Trans Signal Processing1996，44，1： | 1 |
| 11 | Adsorption of temperate phages of Lactobacillus delbrueckii strains and phage resistance linked to their cell diversity显示文摘 | Trucco V Reinheimer J Quiberoni A | 2011 | J Appl Microbiol2011，110，4： | 1 |
| 12 | Analysis of the al- pha/beta T-cell receptor repertoire by competitive and quanti- tative family-specific PCR with exogenous standards and high resolution fluorescence based CDR3 size imaging显示文摘 | Manfras B J Rudert WA Trucco M | 1997 | J Im- munol Methods1997，210，2： | 1 |
| 13 | Chi- merism and donor specific nonreactivity 27 to 29 years after kidney allotransplantation 显示文摘 | Starzl T E Demetris A J Trucco M | 1993 | Transplantation1993，55，： | 1 |
| 14 | Experiments in curvature-based segmentation of range data显示文摘 | TruccoE Fisher R B | 1995 | IEEE Transaction on Pattern Analysis and Machine Intelligence1995，17，2： | 1 |
| 15 | A compact algorithm for rectification of stereo pairs显示文摘 | TRUCCO E | 2000 | Machine Vision and Applications2000，12，1： | 1 |
| 16 | A compact algorithm for rectification of stereo pairs显示文摘 | Fusiello A Trucco E | 2000 | Machine Vision and Applications2000，12，1： | 1 |
| 17 | Cell migration and chimerism after whole-organ transplantation:the basis of graft acceptance显示文摘 | Starzl TE Demetris AJ Trucco M | 1993 | Hepatology1993，17，： | 1 |
| 18 | A compactalgorithm for rectification of stereo pairs显示文摘 | FUSIELLO A TRUCCO E VERRI A | 2000 | MachineVision and Applications2000，12，1： | 1 |
| 19 | Modelling and assessment of dependent performance shaping factors through Analytic Network Process显示文摘 | De Ambroggi M Trucco P | 2011 | Reliability Engineering and System Safety2011，，96： | 1 |
| 20 | Stochastic optimization of linear sparse array显示文摘 | Trucco A Murino V | 1999 | IEEE Journal of Oceanic Engineering1999，24，3： | 1 |
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