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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study显示文摘AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic patients.METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours.RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction. | Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group | 2017 | World Journal of Hepatology2017，9，27： | 6 |
| 3 | Ultrasound elastography in liver显示文摘 | N. Frulio H. Trillaud | 2013 | Diagnostic and Interventional Imaging2013，，5： | 2 |
| 4 | MR angiography:noninvasive vascular imaging of the abdomen显示文摘 | Laissy JP Trillaud H Douek P | | 0，，05： | 1 |
| 5 | MR angiography:noninvasive vascular imaging of the abdomen显示文摘 | Laissy JP Trillaud H Douek P | 2002 | Abdom Imag2002，27，5： | 1 |
| 6 | MR angiography:noninvasive vascular imaging of the abdomen显示文摘 | Laissy JP Trillaud H Douek P | 2002 | Abdom imaging2002，27，5： | 1 |
| 7 | Volumetric feedback ablation of uterine fibroids using magnetic resonance-guided high intensity focused ultrasound therapy显示文摘 | Voogt MJ Trillaud H Kim YS | 2012 | Eur Radiol2012，22，2： | 1 |
| 8 | Association of adenoma and focal nodular hyperplasia:experience of a single French academic center显示文摘 | Laurent C Trillaud H Lepreux S | 2003 | Comp Hepatol2003，2，1： | 1 |
| 9 | Influence of ultrasound induced cavitation on magnetic resonance imaging contrast in the rat liver in the presence of macromolecular contrast agent显示文摘 | Frulio Nora Trillaud Hervé Deckers Roel | 2010 | Investigative Radiology2010，45，5： | 1 |
| 10 | MR Angiography: Noninvasive Vascular Imaging of the Abdomen显示文摘 | Laissy JP Trillaud H Douek P | 2002 | Abdomen Imaging2002，27，5： | 1 |
| 11 | Protection and quench detection of YBCO coils results with small test coil assemblies显示文摘 | Frederic Trillaud Ing Chea Ang Woo Seok Kim | 2007 | IEEE Transactions on Applied Superconductivity2007，17，2： | 1 |
| 12 | Normal zone propagation experiments on HTS composite conductors 显示文摘 | Trillaud F | 2003 | Cyogenics2003，43，8： | 1 |
| 13 | MR Angiography: noninva- sive vascular imaging of the abdomen显示文摘 | Laissy JP Trillaud H Douek P | 2002 | Abdomen Imaging2002，27，5： | 1 |
| 14 | Normal zone propagation experiments on HTS composite conductors 显示文摘 | Trillaud F | 2003 | Cryogenics2003，43，3： | 1 |
| 15 | Normal zone propagation in 2-Dimensional YBCO winding pack models显示文摘 | Kim W S Trillaud F Ahn M C | 2008 | IEEE Transactions on Applied Superconductivity2008，18，2： | 1 |
| 16 | Fracture and fracture separation of the proximal humerus in children: report of 136 cases 显示文摘 | Kohler R Trillaud JM | 1983 | J PediatrOrthop1983，3，3： | 1 |
| 17 | MR angiography: noninvasive vascular imaging of the abdomen显示文摘 | Laissy JP Trillaud H Douek P | 2002 | Abdom Imag2002，27，5： | 1 |
| 18 | MR angiography: noninvasive vascular imaging of the abdomen 显示文摘 | Laissy JP Trillaud H Douek P | 2002 | Abdom Imaging2002，27，5： | 1 |
| 19 | MR angiography:noninvasive vascular imaging of the abdomen显示文摘 | Laissy JP Trillaud H Douek P | 2002 | Abdom imaging2002，27，： | 1 |
| 20 | MR Angiography: Noninvasire Vascular Imaging of the Abdomen显示文摘 | Laissy JP Trillaud H o Douek P | 2002 | Abdom Imaging2002，27，5： | 1 |
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