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| 1 | Impairment of the nerve growth factor pathway driving amyloid accumulation in cholinergic neurons the incipit of the Alzheimer's disease story?显示文摘The current idea behind brain pathology is that disease is initiated by mild disturbances of common physiological processes. Overtime, the disruption of the neuronal homeostasis will determine irreversible degeneration and neuronal apoptosis. This could be also true in the case of nerve growth factor(NGF) alterations in sporadic Alzheimer's disease(AD), an age-related pathology characterized by cholinergic loss, amyloid plaques and neurofibrillary tangles. In fact, the pathway activated by NGF, a key neurotrophin for the metabolism of basal forebrain cholinergic neurons(BFCN), is one of the first homeostatic systems affected in prodromal AD. NGF signaling dysfunctions have been thought for decades to occur in AD late stages, as a mere consequence of amyloid-driven disruption of the retrograde axonal transport of neurotrophins to BFCN. Nowadays, a wealth of knowledge is potentially opening a new scenario: NGF signaling impairment occurs at the onset of AD and correlates better than amyloid load with cognitive decline. The recent acceleration in the characterization of anatomical, functional and molecular profiles of early AD is aimed at maximizing the efficacy of existing treatments and setting novel therapies. Accordingly, the elucidation of the molecular events underlying APP metabolism regulation by the NGF pathway in the septo-hippocampal system is crucial for the identification of new target molecules to slow and eventually halt mild cognitive impairment(MCI) and its progression toward AD. | Viviana Triaca Pietro Calissano | 2016 | Neural Regeneration Research2016，11，10： | 5 |
| 2 | Neuronal markers expression of NGF-primed bone marow cells transplanted in the brain of 6-hydroxydopamine and ibotenic acid lesioned littermate mice显示文摘 | TRIACA V ALOE L | 2005 | Neurosic Lett2005，384，12： | 1 |
| 3 | The use of extraoral implants for distal-extension removable dentures: a clinical evaluation up to 8 years显示文摘 | Minoretti R Triaca A Saulacic N | 2009 | Int J Oral Maxillofac Implants2009，24，6： | 1 |
| 4 | Laparoscopic radical cystectomy with continent urinary diversion显示文摘 | Canes D Triaca V Tuerk I | 2005 | Current Urology Reports2005，6，2： | 1 |
| 5 | Early stages of platinum electrodeposition on highly oriented pyrolytic graphite:scanning tunneling显示文摘 | ZEBIMENDDI J L VAZQUEZ L OCON P VARA J M TRIACA W E SALVAREZZA R C ARVIA A J | 1993 | The Journal of Physical Chemistry1993，97，： | 1 |
| 6 | Neuronal markers expression of NGF-primed bone marrow cells (BMCs) transplanted in the brain of 6-hydroxydopamine and ibotenic acid lesioned littermate mice显示文摘 | Triaca V Aloe L | 2005 | Neurosci Lett2005，384，12： | 1 |
| 7 | Hydrogen absorption characteristics and electrochemical properties of Ti substitued Zr-based AB2 alloys显示文摘 | Visintin A Peretti H A Tori C A Triaca W E | 1998 | International Journal of Hydrogen Energy1998，26，： | 1 |
| 8 | Electrochim Acta显示文摘 | Zubimendi J L Andreasen G Triaca W E | 1995 | 40:13051995，40，： | 1 |
| 9 | Modified cat'alytic materials for ethanol oxidation显示文摘 | I Bonesi A R Moreno M S Triaca W E | 2010 | International Journal of Hydrogen Energy2010，35，1： | 1 |
| 10 | Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: Apopto- sis vs necrosis显示文摘 | LIEBERTHAL W TRIACA V LEVINE J | 1996 | Am J Physiol1996，270，4： | 1 |
| 11 | Agonistic encounters in aged male mouse potentiate the expression of endogenous brain NGF and BDNF: possible implication for brain progenitor cells' activation 显示文摘 | Fiore M Amendola T Triaca V | 2003 | Eur J Neurosci2003，17，： | 1 |
| 12 | Electrochemical characterization of a hydride-forming metal alloy surface-modified with palladium 显示文摘 | BARSELLINI D VISINTIN A TRIACA W E SORIAGA M P | 2003 | J Power Sources2003，124，1： | 1 |
| 13 | A 6 year experience with the Swedish adjustable gastric band prospective long-term audit of laparoscopic gastric banding显示文摘 | Zehetner J Holzinger F Triaca H | | 0，，： | 1 |
| 14 | Role of superoxide in apoptosis induced by growth factor withdrawal显示文摘 | Lieberthal W Triaca V Koh JS | 1998 | Am J Physiol1998，275，52： | 1 |
| 15 | A randomized double-blind prospective study evaluating patient tolerance of transrectal ultrasound-guided biopsy of the prostate using prebiopsy rofecoxib显示文摘 | Moinzadeh A Mourtzinos A Triaca V | | 0，，： | 1 |
| 16 | Reconstruction and rehabilitation of severe mandibular atrophy using distraction osteogenesis technique: a case report 显示文摘 | Triaca A Garibaldi J Simonetti M | 2014 | J Oral Maxil-lofac Surg2014，72，12： | 1 |
| 17 | Ein neues Titan-Flachschrauben-Implantat zur orthodontischen Verankerrung am anterioren Gaumen显示文摘 | Antonini M Wintermantel E | 1992 | Informationen aus Orthodontie and Kzieferorthopadie1992，24，： | 1 |
| 18 | Chin shield osteotomy-a new genioplasty technique avoiding a deep mento-labial fold in order to increase the labial Competence 显示文摘 | Triaca A Furrer T Minoretti R | 2009 | Oral Maxillofac Surg2009，38，： | 1 |
| 19 | Coordinated chemoradiation therapy with genital preservation for the treatment of primary invasive carcinoma of the male urethra显示文摘 | Cohen MS Triaca V Billmeyer B | 2008 | J Urol2008，179，2： | 1 |
| 20 | Lysophosphatidic acid: a novelgrowth and survival factor for renal proximal tubular cells 显示文摘 | Levine JS Koh JS Triaca V | 1997 | Am JPhysiol1997，273，42： | 1 |
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