|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | European evidence based consensus on the diagnosis and management of Crohn's disease:current management显示文摘 | Travis SPL Stange E F Lémann M | 2006 | Gut2006，55，： | 1 |
| 3 | Ele- vated CO2 increases productivity and invasive species success in an arid ecosystem显示文摘 | STANLEY D S Travis E H Stephen F Z | 2000 | Nature2000，408，2： | 1 |
| 4 | Cosine Families and Abstract Nonlinear Second Order-differential Equations显示文摘 | C C Travis G F Webb | 1978 | Acta Mathematica Mcademiae Scientiaruin Hungaricae Tomus1978，32，34： | 1 |
| 5 | A computational fluid dynamics model of a solid oxide fuel cell显示文摘 | K Sudaprasert R P Travis R F Martinez-Botas | 2005 | ProQuest Science Jounals2005，159，： | 1 |
| 6 | Primitive hematopoietic cells in murine bone marrow express the CD34 antigen显示文摘 | Morel F Szilvassy S J Travis M | 1988 | Blood1988，，10： | 1 |
| 7 | High-order incompressible large-eddy simulation of fully inhomo- geneous turbulent flows 显示文摘 | Dinesh A S Travis C F Aditya R C | 2010 | Journal of Computa- tional Physics2010，229，23： | 1 |
| 8 | Distribution of sulfamethazine, chlortetracycline and tylosin in manure and soil of Canadian feedlots af- ter subtherapeutic use in cattle显示文摘 | Aust M O Godlinski F Travis G R | 2008 | Environmental Pollution2008，156，3： | 1 |
| 9 | Introducing a stochastic movement simulator/ for estimatinghabitat connectivity 显示文摘 | Palmer S C F Coulon A Travis J M J | 2011 | Methods in Ecology and Evolution2011，2，3： | 1 |
| 10 | Cancer surveillance series:non-Hodgkin's lymphoma incidence by histologic subtype in the United States from 1978 through 1995显示文摘 | Groves F D Liner M S Travis L B | 2000 | J Natl Cancer Inst2000，92，15： | 1 |
| 11 | on the Deep Drawing of Cups with Punch and Blank-Holding Forces Proportional to a Hydraulic Pressure显示文摘 | Thiruvarudchelvan S Travis F W Poh T K | 1999 | Journal of Materials Processing Technology1999，9293，1： | 1 |
| 12 | Existence Stability and Compactness in the a-norm for Partial Functional Differential Equations显示文摘 | C C Travis G F Webb | 1978 | Trans Amer Math Soc1978，240，： | 1 |
| 13 | Essential fish habitat and marine reserves: an introduciton to the second mote symposium in fisheries ecology显示文摘 | CONOVER D O TRAVIS J COLEMAN F C | 2000 | Bulletin of Marine Science2000，66，3： | 1 |
| 14 | Comparison of coherence, amplitude, and eloreta patterns during transcendental meditation and TM-sidhi practice显示文摘 | Travis F | 2011 | Int J Psyehophysiol2011，81，3： | 1 |
| 15 | Elevated CO2 increases productivity and invasive species success in an arid ecosystem 显示文摘 | Stanley D S Travis E H Stephen F Z | 2000 | Nature2000，408，2： | 1 |
| 16 | Existence and stability for partial functional differential equations显示文摘 | Travis C C Webb G F | 1974 | Trans Amer Math Soc1974，200，： | 1 |
| 17 | Existence and stability for reversible senigrouos of Lipschitzian mappings in Banach spaces 显示文摘 | TRAVIS C C WEBB G F | 2000 | Dyn Syst Appl2000，9，2： | 1 |
| 18 | Distribution of sulfamethazine,chlortetracycline and tylosin in manure and soil of Canadian feedlots after subtherapeutic use in cattle 显示文摘 | AUST M O GODLINSKI F TRAVIS G R | 2008 | Environmental Pollution2008，156，3： | 1 |
| 19 | Existence and stability for reversible semigroups of Lipschitzian mappings in Banach spaces 显示文摘 | TRAVIS C C WEBB G F | 2000 | Dyn Syst & Appl2000，9，2： | 1 |
| 20 | Existence and stability for reversible semigroups of Lipschitzian mappings in Banach spaces显示文摘 | TRAVIS C C WEBB G F | 2000 | Dyn Syst Appl2000，9，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员