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| 1 | Optimizing outcomes for patients with gastric cancer peritoneal carcinomatosis显示文摘Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival out-comes. Positive peritoneal cytology similarly worsens the survival of patients with gastric cancer and treatment options for these patients have been limited. Recent ad-vances in multimodality treatment regimens have led to innovative ways to care for and treat patients with this disease burden. One of these advances has been to use neoadjuvant therapy to try and convert patients with positivecytologyorlow-volume PC to negative cytolo-gy with no evidence of active peritoneal disease.These strategies include the use of neoadjuvant systemic chemotherapy alone,using neoadjuvant laparoscopic heated intraper itoneal chemotherapy(NLHIPEC)after systemic chemotherapy,or using neoadjuvant intra-peritoneal and systemic chemother apy(NIPS)in a bi-dir ectional manner. For patients with higher volume PC,cytoreductive surgery (CRS) and hyperthermic intrape-ritoneal chemotherapy(HIPEC)have been mainstays of treatment. When used together, CRS and HIPEC can improve overall outcomes in properly selected patients,but overall survival outcomes remain unacceptably low.The extent of peritoneal disease, commonly measured by the peritoneal carcinomatosis index (PCI), and the com-pleteness of cytor eduction,has been shown to greatly impact outcomes in patients undergoing CRS and HIPEC.The uses of NLHIPEC and NLHIPEC plus NIPS have both been shown to decrease the PCI and thus increase the opportunity for complete cytoreduction. Newer therapies like pressurized intraperitoneal aerosol chemother apy and immunotherapy, such as catumaxomab, along with improved systemic chemotherapeutic regimens, are being explored with great interest.There is exciting progress being made in the management of PC from gastric can-cer and its’ treatment is no longer futile. | Jennifer L Leiting Travis E Grotz | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 4 |
| 2 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 3 | The new World Health Organization classification of lung mmours显示文摘 | Brambilla E Travis WD Colby TV | 2001 | Eur RespirJ2001，18，6： | 1 |
| 4 | Outcome Following Open Reduction and Internal Fixation of Open Pilon Fractures显示文摘 | SREEVATHSA B TRAVIS JK ANDREW E | 2010 | The Journal of Bone and Joint Surgery (American)2010，92，2： | 1 |
| 5 | The 2004 World Health Organization classification of lung tumors 显示文摘 | Beasley MB Brambilla E Travis WD | 2005 | Semin Roentgenol2005，40，2： | 1 |
| 6 | European evidence based consensus on the diagnosis and management of Crohn's disease:current management显示文摘 | Travis SPL Stange E F Lémann M | 2006 | Gut2006，55，： | 1 |
| 7 | Knowledge discovery in medical and biological datasets using a hybrid Bayes classifier/evolutiomry algorithm 显示文摘 | Michael L Raymer Travis E | 2003 | IEEE Tmnsactiom on Systems Man and Cybernetics2003，2003，2： | 1 |
| 8 | A survey of sorption relationships for reactive solutes in soil显示文摘 | Travis C C Etnier E L | 1981 | Journal of Environmental Quality1981，10，1： | 1 |
| 9 | The new World Health Organization classification of lung tumors显示文摘 | Brambilla E Travis WD Colby TV | 2001 | Eur Respir J2001，18，6： | 1 |
| 10 | Ele- vated CO2 increases productivity and invasive species success in an arid ecosystem显示文摘 | STANLEY D S Travis E H Stephen F Z | 2000 | Nature2000，408，2： | 1 |
| 11 | Estimation of the spatial distribu- tion of target cells for radiation pneumonitis in mouse lung 显示文摘 | Tucker S L Liao Z X Travis E L | 1997 | Int J Radiat Oncol Biol Phys1997，38，5： | 1 |
| 12 | The 2004 World Health Or- ganization classification of lung tumors 显示文摘 | Beasley MB Brambilla E Travis WD | 2005 | Semin Roentgenol2005，40，2： | 1 |
| 13 | The new world health organization classification of lung tumours 显示文摘 | Brambilla E Travis W D Colby T V | 2001 | Europ Respirat J2001，18，6： | 1 |
| 14 | The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification显示文摘 | TRAVIS W D BRAMBILLA E NICHOLSON A G | 2015 | J Thorae Oneol2015，10，9： | 1 |
| 15 | A high-density soybean genetic map based on AFLP markers 显示文摘 | Keim P Schupp J M Travis S E | 1997 | Crop Sci1997，37，： | 1 |
| 16 | The 2004 World Health Or- ganization classification of lung tumors 显示文摘 | Beasley Mb Brabilla E Travis Wd | 2005 | Semin Roentgenol2005，40，2： | 1 |
| 17 | Fibroblast radiosensitivity in vitro and lung fibrosis in vivo: Comparison between a fibrosis- prone and fibrosis-resistant mouse strain 显示文摘 | Dileto C L Travis E L | 1996 | Radiation Research1996，146，： | 1 |
| 18 | Modeling Spe-cies′ Range Shifts in a Changing Climate:the Impacts of Biotic In-teractions,Dispersal Distance and the Rate of Climate Change显示文摘 | BROOKER R W TRAVIS J M J CLARK E J | 2007 | Journal of Theoretical Biology2007，245，1： | 1 |
| 19 | International Association for the Study of Lung Cancer/Amerlcan Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary显示文摘 | Travis WD Brambilla E Noguchi M | 2011 | Proc Am Thorac Soc2011，8，5： | 1 |
| 20 | The 2004 World Health Organization classification of lung tumors显示文摘 | Beasley MB Brambilla E Travis WD | 2005 | Semin Roentgenol2005，40，2： | 1 |
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