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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Overcoming health-systems constraints to achieve the Millennium Development Goals 显示文摘 | Travis P Hennett S Haines A | 2004 | Lancet2004，364，： | 1 |
| 3 | Evidence that monoclonal antibodies directed against the integrin β subunit plexin/ semaphorin/integrin domain stimulate function by inducing receptor extension显示文摘 | Mould A P Travis M A Barton S J | 2005 | J Biol Chem2005，280，6： | 1 |
| 4 | LEF-l,a gene encoding a lymphoid-specific protein with an HMG domain,regulates T-cell re?ceptor alpha enhancer function显示文摘 | Travis A Amsterdam A Belanger C | 1991 | Genes Dev1991，5，5： | 1 |
| 5 | The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification显示文摘 | TRAVIS W D BRAMBILLA E NICHOLSON A G | 2015 | J Thorae Oneol2015，10，9： | 1 |
| 6 | Complete temporal characterization of a single photon显示文摘Precise information about the temporal mode of optical states is crucial for optimizing their interaction efficiency between themselves and/or with matter in various quantum communication devices.Here we propose and experimentally demonstrate a method of determining both the real and imaginary components of a single photon’s temporal density matrix by measuring the autocorrelation function of the photocurrent from a balanced homodyne detector at multiple local oscillator frequencies.We test our method on single photons heralded from biphotons generated via four-wave mixing in an atomic vapor and obtain excellent agreement with theoretical predictions for several settings. | Zhongzhong Qin Adarsh S Prasad Travis Brannan Andrew MacRae A Lezama AI Lvovsky | 2015 | Light(Science & Applications)2015，4，1： | 1 |
| 7 | Immune reconstitution associated with progressive multifocal leukoencephalopathy in human immunodeficiency virus: a case discussion and review of the literature 显示文摘 | Travis J Varma A duPlessis D | 2008 | Neurologist2008，14，： | 1 |
| 8 | Weight and symptom diary for self-monitoring in heart failure 显示文摘 | Cathy A Lucille Travis Tanya T | 2008 | J Cardiovasc Nurs2008，22，5： | 1 |
| 9 | Characterization of a pollen-specific cDNA clone from Zea mays and its expression 显示文摘 | Hanson D D Hamilton D A Travis J L | 1989 | Plant Cell1989，1，2： | 1 |
| 10 | Composition-structure Relationships in Simplified Nuclear Waste Glasses:Mixed Alkali Borosilicate Glasses显示文摘 | Connelly A J Travis K P Hyatt N C | 2011 | Journal of the American Ceramic Soeiety2011，94，1： | 1 |
| 11 | Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents 显示文摘 | Travis G H Golczak M Moise A R | 2006 | Annu Rev Pharmacol Toxicol2006，47，： | 1 |
| 12 | Electromagnetic Induction by a Finite Electric Dipole Source Over a 2-D Earth显示文摘 | Unsworth M J Travis B J Chave A D | 1993 | Geophysics1993，58，1： | 1 |
| 13 | Guidelines for themanagement of inflammatory bowel disease in adults显示文摘 | Carter M J Lobo A J Travis S P L | 2004 | Gut2004，53，9： | 1 |
| 14 | Rootstock effects on gene expression patterns in apple tree scions显示文摘 | JENSEN P J RYTTER J DETWILER E A TRAVIS J W MCNELLIS T W | 2003 | Plant Molecular Biology2003，53，4： | 1 |
| 15 | Nitric oxide synthase cyclooxygenase-2,and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma显示文摘 | Marrogi A J Travis W D Welsh J A | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 16 | High-order incompressible large-eddy simulation of fully inhomo- geneous turbulent flows 显示文摘 | Dinesh A S Travis C F Aditya R C | 2010 | Journal of Computa- tional Physics2010，229，23： | 1 |
| 17 | 16S rDNA library-based analysis of ruminal bacterial diversity 显示文摘 | EDWARDS J E MCEWAN N R TRAVIS A J | 2004 | Antonie Van Leeuwenhoek2004，，3： | 1 |
| 18 | Coalition formation for task allocation:Theory and algorithms显示文摘 | Travis C S Julie A A | | 0，，22： | 1 |
| 19 | Introducing a stochastic movement simulator/ for estimatinghabitat connectivity 显示文摘 | Palmer S C F Coulon A Travis J M J | 2011 | Methods in Ecology and Evolution2011，2，3： | 1 |
| 20 | The mononuclear pha-gocyte system in homeostasis and disease: a role forheme oxygenase-1显示文摘 | Travis DH Anupam A James FG | 2014 | Antioxid Redox Signal2014，20，11： | 1 |
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